Ann Hematol (2015) 94:1077–1078 DOI 10.1007/s00277-015-2299-x
LETTER TO THE EDITOR
Hepatosplenic γδ T-cell lymphoma after allogeneic bone marrow transplantation Marie-Christiane Vekemans & Lucienne Michaux & Pascale Saussoy & Eric Van Den Neste & Ivan Théate & Augustin Ferrant
Received: 2 December 2014 / Accepted: 3 January 2015 / Published online: 30 January 2015 # Springer-Verlag Berlin Heidelberg 2015
Dear Editor, Hepatosplenic γδ T-cell lymphoma (HSγδTCL) is a rare extranodal T-cell non-Hodgkin lymphoma (NHL) that arises from a small subset of γδ T-cell receptor-expressing lymphocytes. It is characterized by an aggressive clinical course and poor response to conventional chemotherapy. HSγδTCL occurs in both immunocompetent and immunocompromised patients. To the best of our knowledge, it has never been observed after allogeneic bone marrow transplantation (alloSCT). Here, we report the case of a 47-year-old man who developed a HSγδTCL 10 years after an allo-SCT. The patient presented with fever, fatigue, and abdominal discomfort, 10 years after a familial allo-SCT performed for primary myelofibrosis. Physical examination showed marked hepatosplenomegaly in the absence of lymphadenopathy. Laboratory findings included mild thrombocytopenia (127, 000/mm3) and leucopenia (2420/mm3), but normal LDH and liver enzymes. Virological tests were negative for EBV, CMV, HIV, HBV, and HCV. The first bone marrow aspirate was normal. Liver biopsy disclosed sinusoidal infiltration by medium-sized lymphocytes with irregular nucleus that M.
LETTER TO THE EDITOR
Hepatosplenic γδ T-cell lymphoma after allogeneic bone marrow transplantation Marie-Christiane Vekemans & Lucienne Michaux & Pascale Saussoy & Eric Van Den Neste & Ivan Théate & Augustin Ferrant
Received: 2 December 2014 / Accepted: 3 January 2015 / Published online: 30 January 2015 # Springer-Verlag Berlin Heidelberg 2015
Dear Editor, Hepatosplenic γδ T-cell lymphoma (HSγδTCL) is a rare extranodal T-cell non-Hodgkin lymphoma (NHL) that arises from a small subset of γδ T-cell receptor-expressing lymphocytes. It is characterized by an aggressive clinical course and poor response to conventional chemotherapy. HSγδTCL occurs in both immunocompetent and immunocompromised patients. To the best of our knowledge, it has never been observed after allogeneic bone marrow transplantation (alloSCT). Here, we report the case of a 47-year-old man who developed a HSγδTCL 10 years after an allo-SCT. The patient presented with fever, fatigue, and abdominal discomfort, 10 years after a familial allo-SCT performed for primary myelofibrosis. Physical examination showed marked hepatosplenomegaly in the absence of lymphadenopathy. Laboratory findings included mild thrombocytopenia (127, 000/mm3) and leucopenia (2420/mm3), but normal LDH and liver enzymes. Virological tests were negative for EBV, CMV, HIV, HBV, and HCV. The first bone marrow aspirate was normal. Liver biopsy disclosed sinusoidal infiltration by medium-sized lymphocytes with irregular nucleus that M.
