RESEARCH ARTICLE
High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Qian Huang1, Guilian Shang2, Haohua Deng1, Jie Liu1, Yan Mei3, Yancheng Xu1* 1 Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei province, P. R. China, 2 Department of Rheumatology, Tianyou Hospital, Wuhan University of Scienceand Technology, Wuhan, Hubei province, P.R. China, 3 School of Stomatology, Wuhan University, Wuhan, Hubei province, P.R. China * [email protected]
Abstract Objective To investigate mannose-binding lectin (MBL) serum levels in type 2 diabetic patients with and without diabetic retinopathy (DR). OPEN ACCESS Citation: Huang Q, Shang G, Deng H, Liu J, Mei Y, Xu Y (2015) High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes. PLoS ONE 10(7): e0130665. doi:10.1371/journal.pone.0130665 Editor: Kumarasamy Thangaraj, Centre for Cellular and Molecular Biology, INDIA Received: August 26, 2014 Accepted: May 25, 2015 Published: July 2, 2015 Copyright: © 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All files are available via Figshare (http://dx.doi.org/10.6084/m9.figshare. 1293653). Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.
Methods Serum MBL levels were determined in type 2 diabetic patients (N=324) as well as in 300 healthy control Subjects. Multivariate analyses were performed using logistic regression models. Receiver operating characteristic curves (ROC) was used to test the overall predict accuracy of MBL and other markers.
Results Diabetic patients with DR and vision-threatening diabetic retinopathy (VTDR) had significantly higher MBL levels on admission (P
High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Qian Huang1, Guilian Shang2, Haohua Deng1, Jie Liu1, Yan Mei3, Yancheng Xu1* 1 Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei province, P. R. China, 2 Department of Rheumatology, Tianyou Hospital, Wuhan University of Scienceand Technology, Wuhan, Hubei province, P.R. China, 3 School of Stomatology, Wuhan University, Wuhan, Hubei province, P.R. China * [email protected]
Abstract Objective To investigate mannose-binding lectin (MBL) serum levels in type 2 diabetic patients with and without diabetic retinopathy (DR). OPEN ACCESS Citation: Huang Q, Shang G, Deng H, Liu J, Mei Y, Xu Y (2015) High Mannose-Binding Lectin Serum Levels Are Associated with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes. PLoS ONE 10(7): e0130665. doi:10.1371/journal.pone.0130665 Editor: Kumarasamy Thangaraj, Centre for Cellular and Molecular Biology, INDIA Received: August 26, 2014 Accepted: May 25, 2015 Published: July 2, 2015 Copyright: © 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All files are available via Figshare (http://dx.doi.org/10.6084/m9.figshare. 1293653). Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.
Methods Serum MBL levels were determined in type 2 diabetic patients (N=324) as well as in 300 healthy control Subjects. Multivariate analyses were performed using logistic regression models. Receiver operating characteristic curves (ROC) was used to test the overall predict accuracy of MBL and other markers.
Results Diabetic patients with DR and vision-threatening diabetic retinopathy (VTDR) had significantly higher MBL levels on admission (P
