220 Endocrine Care
High Thyroid-Stimulating Hormone Level is Associated with the Risk of Developing Atherosclerosis in Subclinical Hypothyroidism
Authors
CX. Gao1 *, B. Yang2 *, Q. Guo3, LH. Wei4, LM. Tian3
Affiliations
1
Key words ▶ thyroid-stimulating ● hormone ▶ adipokines ● ▶ subclinical hypothyroidism ●
Abstract
Department of Ultrasonic diagnosis, Gansu Provincial Hospital, Lanzhou, China Graduate School, Ningxia Medical University, Yinchuan, Ningxia, China 3 Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China 4 Clinical Laboratory, Gansu Provincial Hospital, Lanzhou, China
▼
The aim of our study was to assess the potential role of thyroid-stimulating hormone (TSH) in the risk of developing atherosclerosis in subclinical hypothyroidism (SCH). A cohort of 240 SCH patients and 150 euthyroid volunteers were recruited for the study. SCH patients were stratified into 2 groups according to TSH levels (group A: TSH 10 mIU/l). All subjects were examined for clinical and biochemical parameters. Visfatin, omentin-1, and circulating endothelial biomarkers were measured. Patients in group B received l-thyroxine replacement to achieve euthyroidism; after 6 months of euthyroidism all measurements were
Introduction
▼ received 29.05.2014 accepted 24.09.2014 Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1394370 Published online: November 5, 2014 Horm Metab Res 2015; 47: 220–224 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence LM. Tian Department of Endocrinology Gansu Provincial Hospital 204 Dong Gang West Road Lanzhou 730000 China Tel.: + 86/152/93184 257 Fax: + 86/931/8266 957 [email protected]
Although subclinical hypothyroidism (SCH) has been determined to be associated with increased risk of developing atherosclerosis [1, 2], its pathology is still unclear. Since SCH is characterized by high concentration of thyroid-stimulating hormone (TSH) and thyroid hormones within the normal level, we hypothesized that TSH might play a key role in the risk of developing atherosclerosis in SCH. Adipose tissue is an endocrine organ, which synthesizes and secretes a wide range of bioactive factors, called adipokines [3]. Previous studies have shown that adipokines can influence fat metabolism and insulin sensitivity [4]. Apart from these properties, recent researches have demonstrated several direct actions of adipokines on cardiovascular function. Some adipokines were suggested as potential diagnostic cardiovascular markers as well as potential therapeutic target for reducing the risk of developing atherosclerosis [5–8]. Recent studies have * The first two authors contributed equally to this work.
Gao CX et al. TSH Contributes to Atherosclerosis … Horm Metab Res 2015; 47: 220–224
repeated. Patients with SCH had higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) levels and lower nitric oxide (NO) and omentin-1 levels compared to euthyroid subjects (all p
High Thyroid-Stimulating Hormone Level is Associated with the Risk of Developing Atherosclerosis in Subclinical Hypothyroidism
Authors
CX. Gao1 *, B. Yang2 *, Q. Guo3, LH. Wei4, LM. Tian3
Affiliations
1
Key words ▶ thyroid-stimulating ● hormone ▶ adipokines ● ▶ subclinical hypothyroidism ●
Abstract
Department of Ultrasonic diagnosis, Gansu Provincial Hospital, Lanzhou, China Graduate School, Ningxia Medical University, Yinchuan, Ningxia, China 3 Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China 4 Clinical Laboratory, Gansu Provincial Hospital, Lanzhou, China
▼
The aim of our study was to assess the potential role of thyroid-stimulating hormone (TSH) in the risk of developing atherosclerosis in subclinical hypothyroidism (SCH). A cohort of 240 SCH patients and 150 euthyroid volunteers were recruited for the study. SCH patients were stratified into 2 groups according to TSH levels (group A: TSH 10 mIU/l). All subjects were examined for clinical and biochemical parameters. Visfatin, omentin-1, and circulating endothelial biomarkers were measured. Patients in group B received l-thyroxine replacement to achieve euthyroidism; after 6 months of euthyroidism all measurements were
Introduction
▼ received 29.05.2014 accepted 24.09.2014 Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1394370 Published online: November 5, 2014 Horm Metab Res 2015; 47: 220–224 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence LM. Tian Department of Endocrinology Gansu Provincial Hospital 204 Dong Gang West Road Lanzhou 730000 China Tel.: + 86/152/93184 257 Fax: + 86/931/8266 957 [email protected]
Although subclinical hypothyroidism (SCH) has been determined to be associated with increased risk of developing atherosclerosis [1, 2], its pathology is still unclear. Since SCH is characterized by high concentration of thyroid-stimulating hormone (TSH) and thyroid hormones within the normal level, we hypothesized that TSH might play a key role in the risk of developing atherosclerosis in SCH. Adipose tissue is an endocrine organ, which synthesizes and secretes a wide range of bioactive factors, called adipokines [3]. Previous studies have shown that adipokines can influence fat metabolism and insulin sensitivity [4]. Apart from these properties, recent researches have demonstrated several direct actions of adipokines on cardiovascular function. Some adipokines were suggested as potential diagnostic cardiovascular markers as well as potential therapeutic target for reducing the risk of developing atherosclerosis [5–8]. Recent studies have * The first two authors contributed equally to this work.
Gao CX et al. TSH Contributes to Atherosclerosis … Horm Metab Res 2015; 47: 220–224
repeated. Patients with SCH had higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and C-reactive protein (CRP) levels and lower nitric oxide (NO) and omentin-1 levels compared to euthyroid subjects (all p
