HHS Public Access Author manuscript Author Manuscript
Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. Author manuscript; available in PMC 2017 June 21. Published in final edited form as:
Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. 2016 May ; 24: 2829–.
Highly Accelerated, Intravascular T1, T2, and Proton Density Mapping with Linear Algebraic Modeling and Sensitivity Profile Correction at 3T Guan Wang1,2, Yi Zhang2, Shashank Sathyanarayana Hegde2,3, and Paul A. Bottomley2
Author Manuscript
1Dept.
of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, United
States 2Russell
H. Morgan Dept. of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States
Synopsis
Author Manuscript
Vessel wall MRI with intravascular (IV) detectors can produce superior local signal-to-noise ratios (SNR) and generate high-resolution T1, T2, and proton density (PD) maps that could be used to automatically classify atherosclerotic lesion stage. However, long acquisition times potentially limit multi-parametric mapping. Here, for the first time, spectroscopy with linear algebraic modeling (SLAM) is applied to yield accurate compartment-average T1, T2 and PD measures at least 10 times faster compared to a standard full k-space reconstructed MIX-TSE sequence at 3T. Simple phase and magnitude sensitivity corrections are incorporated into the SLAM reconstruction to compensate for IV detector non-uniformity.
PURPOSE
Author Manuscript
Vessel wall MRI with intravascular (IV) detectors can produce superior local signal-to-noise ratios (SNR) [1] and high resolution (
Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. Author manuscript; available in PMC 2017 June 21. Published in final edited form as:
Proc Int Soc Magn Reson Med Sci Meet Exhib Int Soc Magn Reson Med Sci Meet Exhib. 2016 May ; 24: 2829–.
Highly Accelerated, Intravascular T1, T2, and Proton Density Mapping with Linear Algebraic Modeling and Sensitivity Profile Correction at 3T Guan Wang1,2, Yi Zhang2, Shashank Sathyanarayana Hegde2,3, and Paul A. Bottomley2
Author Manuscript
1Dept.
of Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD, United
States 2Russell
H. Morgan Dept. of Radiology & Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States
Synopsis
Author Manuscript
Vessel wall MRI with intravascular (IV) detectors can produce superior local signal-to-noise ratios (SNR) and generate high-resolution T1, T2, and proton density (PD) maps that could be used to automatically classify atherosclerotic lesion stage. However, long acquisition times potentially limit multi-parametric mapping. Here, for the first time, spectroscopy with linear algebraic modeling (SLAM) is applied to yield accurate compartment-average T1, T2 and PD measures at least 10 times faster compared to a standard full k-space reconstructed MIX-TSE sequence at 3T. Simple phase and magnitude sensitivity corrections are incorporated into the SLAM reconstruction to compensate for IV detector non-uniformity.
PURPOSE
Author Manuscript
Vessel wall MRI with intravascular (IV) detectors can produce superior local signal-to-noise ratios (SNR) [1] and high resolution (
