Accepted Manuscript HIV-Serodiscordant Couples Desiring a Child: “Treatment as Prevention”, PreExposure Prophylaxis, or Medically Assisted Procreation? Guillaume Mabileau, MSc, Michael Schwarzinger, MD, Juan Flores, BA, Catherine Patrat, PhD, Dominique Luton, PhD, Sylvie Epelboin, MD, Laurent Mandelbrot, PhD, Sophie Matheron, PhD, Yazdan Yazdanpanah, PhD PII:

S0002-9378(15)00459-7

DOI:

10.1016/j.ajog.2015.05.010

Reference:

YMOB 10393

To appear in:

American Journal of Obstetrics and Gynecology

Received Date: 13 November 2014 Revised Date:

5 May 2015

Accepted Date: 6 May 2015

Please cite this article as: Mabileau G, Schwarzinger M, Flores J, Patrat C, Luton D, Epelboin S, Mandelbrot L, Matheron S, Yazdanpanah Y, HIV-Serodiscordant Couples Desiring a Child: “Treatment as Prevention”, Pre-Exposure Prophylaxis, or Medically Assisted Procreation?, American Journal of Obstetrics and Gynecology (2015), doi: 10.1016/j.ajog.2015.05.010. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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ACCEPTED MANUSCRIPT

HIV-Serodiscordant Couples Desiring a Child: “Treatment as Prevention”, Pre-Exposure Prophylaxis, or Medically Assisted Procreation? Authors: Guillaume MABILEAU, MSc1,2

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Michael SCHWARZINGER, MD1,2 Juan FLORES, BA1,3 Catherine PATRAT, PhD2,4

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Dominique LUTON, PhD2,5,6 Sylvie EPELBOIN, MD5

Sophie MATHERON, PhD1,2,8 Yazdan YAZDANPANAH, PhD1,2,8 Affiliation:

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Laurent MANDELBROT, PhD2,6,7

INSERM, IAME, UMR 1137, F-75018 Paris, France

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Université Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France

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Mailman School of Public Health, Columbia University, New York City, NY 10027, USA

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AP-HP, Bichat-Claude Bernard Hospital, Reproductive Biology Department, F-75018 Paris, France

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AP-HP, Bichat-Claude Bernard Hospital, Gynecology Obstetrics Department, F-75018 Paris, France

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Departement Hospitalo-Universitaire “Risk and Pregnancy”, Paris, France

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AP-HP, Louis Mourier Hospital, Gynecology Obstetrics Department, Colombes, France

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AP-HP, Bichat-Claude Bernard Hospital, Infectious Diseases Department, F-75018 Paris, France

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Conflict of interest: Y. Y. is a board member and reports receiving consultancy honoraria from Abbott, BMS, Gilead, MSD, Roche, Tibotec, and ViiV Healthcare; he also reports receiving honoraria for development of educational presentations from Abbott, BMS, Gilead, Tibotec, and ViiV Healthcare. None of other authors have any conflict of interest associated with the work presented in this manuscript. Funding: The study was supported by a funding number ANRS-12008 from the French Agence National de Recherche sur le Sida et les Hépatites Virales (ANRS)

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ACCEPTED MANUSCRIPT Presentation: This study was presented at the 15th National Infectious Diseases Days, Bordeaux, France, June 11-13, 2014; and at the 22nd Conference On Retroviruses And Opportunistic Infections, Seattle, WA, February 23-26, 2015. Corresponding author: Guillaume MABILEAU, INSERM, IAME, UMR1137, UFR de Médecine, 16 rue

Word count: Abstract (298 words), Main text (3,877)

Condensation and short version of title:

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Henri Huchard, 75018 Paris, France, Tel: +33 1 57 27 75 71, E-mail: [email protected]

Targeting fertile days for conception in HIV- female/HIV+ male couples, at low risk of HIV-

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Short title: Procreation in HIV-Serodiscordant couples

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transmission, is more cost-effective than pre-exposure prophylaxis and MAP.

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ACCEPTED MANUSCRIPT Abstract: Objective: To assess the residual risk of HIV-transmission, cost, and cost-effectiveness of various strategies that can help fertile HIV-uninfected female/HIV-1-infected male on combination antiretroviral therapy with plasma HIV RNA

HIV-serodiscordant couples desiring a child: 'treatment as prevention,' preexposure prophylaxis, or medically assisted procreation?

We sought to assess the residual risk of HIV transmission, cost, and cost-effectiveness of various strategies that can help fertile HIV-uninfected fem...
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