HLA Class I1 nucleotide sequences, 1992 S . G . E. Marsh, J. G . Bodmer. HLA Class 11 nucleotide sequences, 1992. Tissue Antigens 1992: 40: 229-243. 0 Munksgaard 1992

Abstract: The HLA Class I1 sequences included in this compilation are taken from publications listed in the papers: Nomenclature for factors of the HLA system, 1991 (I), Nomenclature for factors of the HLA system, 1990 (2), and Nomenclature for factors of the HLA system, 1989 (3). Where discrepancies have arisen between reported sequences, the original authors have been contacted, where possible, and necessary amendments to published sequences have been incorporated into this alignment. Future sequencing may identify errors in this list and we would welcome any evidence that helps to maintain the accuracy of this compilation. In the sequence alignments, identity between residues is indicated by a hyphen (-). An unavailable sequence is indicated by an asterisk (*), gaps in the sequence are inserted to maintain the alignment between different alleles showing variation in amino acid number.

Stevei 6. E. Marsb and Julia 6. Bodmer Tissue Antigen Laboratory, Imperial Cancer Research Fund, Lincoln’s Inn Fields, London, United Kingdom.

Received and accepted for publication 18 August 1992

Corrections Since this alignment was last published (4) several errors in the sequences have been brought to our attention and the sequences corrected. 1. DQB1*0601 codon 5 1 previously ‘ACC’ corrected to ‘ACG’.

2. DPB1*0101 codon 153 previously ‘ATC’ corrected to ‘TTC’ codon 179 previously ‘GAT’ corrected to ‘GAC’ codon 181 previously ‘TCC’ corrected to ‘CCT’ codon 214 previously ‘GGA’corrected to ‘GGC’ corrected to ‘ATC’ codon 2 15 previously ‘CTC’

3. DPB1*1001 codon 34 previously ‘GAA’ corrected to ‘GAG’ We would like to thank Dr Akinori Kimura and

Prof. Jiirgen Frey for correcting these sequences.

229

Marsh & Bodmer

DRB Sequences: DR01*0101 DRBI'OIO? DRB1.0103 DRB1*1501

DRBl*lSOZ ORB1 '1503 DR01.1601

DRB1.0303

DRBl.0401 ORB1'0402 DRBl*0403

ORBI*OJ04 DR61-0405 DRB1.0406 0RB1.0407 DRSl'O408

DRB1*0409 DRB1.0410 DR01.0411

DRB1.0412 !JRBl*llOll DRBl*llOlZ DRB1.1102 DRB1.1103

0881*11041 DRBl.11042 ORB1.1201 DRB1*1202 DRB1.1301 DRB1*1302 DRB1'1303 DRBl-1304 DRB1-1305

DRB1.1404 DRB1'1405 ORB131406 DRB1*1407

DRB1*1408 8RB1'1409

DRBl '34 10 ORB1'0701

ORB1'0702 ORBl'OBOl DRB1.08021 DRB1%0022

DR01.08031 DR81.08032

ORB1.0804

DRB3.0201

ORB3*0202 ORB3'0301 DR04.0101 DRB5.0101

ORBS'OlOZ DRB5*0201 DRBS.0202

DRB6-0202

DRB7 DRB8 DRB9

HLA Class I1 nucleotide sequences, 1992 DRB Sequences: ORB1'0101 ORB1.0102 DRB1.0103 ORB1*1501 ORB1.1502 ORB1*1503 ORB1'1601 ORB1.1602 ORB1.0301 ORB1'0302 ORB1.0303 I)RBl*O401 ORB1'0402 ORB1'0403 ORB1.0404 DRB1'0405 ORBl-0406 ORB1'0407 ORB1*0408 ORB1'0409 ORB1.0410 ORB1.0411 ORB1*0412 ORB1'11011 DRB1.11012 ORB1'1102 ORB1 *1103 ORBl*llO41 ORBl*lIO42 ORB1*1201 ORB1 -1202 ORB1.1301 ORB1*1302 ORB1.1303 ORB1'1304 ORB1'1305 ORB1'1306 ORB1.1401 ORB1.1402 ORB1.1403 DRBl-I404 ORB1'1405 ORBl'l406 ORB1.1407 DRB1-1408 ORB1*1409 ORB1+1410 ORB1'0701 ORB1.0702 ORB1*0801 ORB1.08021 ORB1.08022 ORB1'08031 ORB1'08032 DRBl.0804 ORB1.0805 ORB1'09011 DRBI-09012 ORB1 '1001 ORB3-0101 DR33-0201 OR93'0202 DRB3.0301 ORB4.0101 DRB5'0101 DRB5*0102 ORBS'0201 ORB5'0202 OR32 ORB6'01Ol ORB6'0201 DRB6'0202 OR37

OR98 OR39

231

Marsh & Bodmer DRB Sequences: DRB1.0101 DRB1-0102 DRS1*0103 DRB1.1501 DRB1.1502 DRBl *1503 DRB1.1601 DRB1.1602 DRB1.0301 ORB1*0302 DRB1.0303 DRB1.0401 DRB1'0402 DRBl.0403 DRB1.0404 DRB1*0405 01181-0406 DRB1.0407 DRB1.0408 DRB1.0409 DRB1.0410 DRBl-04 11 DRBl *O412 DRB1*11OlI DRBl-11012 DRB1.1102 DRB1*1103 DRB1*11041 DRB1.11041 DRB1.1201 DRB1.1202 DRB1.1301 DRB1.1302 DRB1.1303 DRB1.1304 DRB1.1305 DRB1*1306 DRB1*1401 DRB1'1402 DRB1.1403 DRB1.1404. DRB1-1405 DRB1.1406 DRB1'1407 DRBl*1408 DRB1.1409 DRB1.1410 ORB1 '07 01 DRB1*0102 DRB1*0801 DRB1*08021 DRB1.08022 DRB1'08031 DRB1'08032 DRBl'OSO4 QRB1*0005 DRB1*09011 DRB1'09012 DRB1'1001 DRB3'0101 DRB3'0201 DRB3-0202

DRB3.0301 DRB4.0101 DRBS*OlOl QRB5*0102 DRBS'0201 DRB5.0202 OR82 DRB6*0101 ORB6*0201 DR86.0202

DRBl

DRBB ORBS

232

HLA Class I1 nucleotide sequences, 1992 DRB Sequences: DRB1.0101

DRBl *0101 DRB1.0103 DRB1'1501 DRB1.1502 DRB1'1503 DRB1.1601 DRB1*1602 DRB1'0301 DRB1.0302 DRB1.0303 DRBl *O401 DRB1'0402 DRB1.0403 DRB1.0 4b 4 DRBlV405 DRBlV406

DRB1.0407 DRB1.0108 DRB1.0409 DRB1'0410 DRBl W 4 1 1 DRBl *0411 DRB1*11011 DRB1.11012 DRBl*1102 DRB1.1103 DRB1'11041 DRB1*11042 DRBl*1201 DRB1.1202 DRB1.1301 DRB1.1302 DRB1.1303 DRB1'1304 DRB1'1305 DRR1'1306

DRB1.1401 DRB1.1402 DRB1.1403 DRB1.1404 DRBl'l405 DRB1.1406 DRB1.1401 DRB1'1408 DRB1.1409 DR01'1410 DRB1.0101 DR01'0102 ORBl'O801 DRBl'O8021 ORB1 '08022 DRB1.0803 1 DRB1'08032 DRB1.0804 DRBl'O805 DRB1.09011 DRB1'09012 DRB1'1001 URB3-0101 DRB3.0201 ORB3 '0202 DRB3'0301 DRB4'0101 DRBS-0101 DRB5'0102 DRB5-0201 DR05'0202 ORB2 DRB5W101 DRPd'O201 DRB6.0202 ORB1 DUB8 DRB9

___ --_ -- - --_ __---_ __---_ --- --......... *. .* ......

...... ... ............ ...... ......... ...... .. ......... ...... ... ..,....... ......... ...... ......... ...... ....... ...... ... ......... - __ - - - - - - --_ __--....... - - - ..___ --_ ...... ...... ...... ... ......... ... ... ...... .*. .ff ___ ___ ___ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ _ _ _ ___ _ _ _ ___ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___

--- ----- ___ --. * . ...... ... ...... ...... ... ...... ......... ... ... ... ... ... .*.... ...... ... ... ... ...... ... _ _ ---- --- __-___ _ _ _ --- ___ _--

--- c-- --.** . . I .

*.*

0,.

.I.

.(I.

.*

*.

*.

.*.

.*(I

.**

*.*

.*. *.* *.*

.*. .** .I.

*.*

. . I

*.

*.

.** *.

*.

**.

f..

___ __---- __-_-- __- __---- _-- --- --...... ...... ,*. .** .*. ...... -A-

...... ...... ... ...... ............ ... ...... . * ... ......... ......... ...... ...... ... ...... ... ... ...... ...... ...... ...... ...... ... _-- __---- _-- __---- ___ _-- ___ --- __. . I .

**.

f**

.If

.*.

. I . .

***

. . 1

.** **.

0.0

.*.

.*.

.*.

.**

11.0

. . 1

*** *.

1..

*.

**.

f

*.*

.*

*** *.

f..

*.

--T **. --T

.*.

*.

.AI.

.*

*.*

I..

f..

--T

* * * **. **.

**.

.** .*.

--T

....................................................................................................... ........................................................................................................ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ _-____ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ _-_ ___ ___ ....................................................................................................... ___ _ _ _ ___ ___ ___ ___ _ _ _ _ _ _ ___ ___ ___ ___ _ _ ___ _ _ _ ___ ___ ___ ___ ___ ___ _ _ _ ___ ___ ___ _ _ _ ___ _ _ _ ___ ___ ___ ....................................................................................................... ....................................................................................................... ....................................................................................................... ....................................................................................................... ...................................................................................................... ....................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... _ _ _ _ _ _ ___ ___ _ _ _ _ _ _ ___ - - - _ - - --- - - - --- --- - - - --- --_ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ --_ --- - _ _--- - - _ --- --- --- --_...................................................................................................... _ _ ___ ___ _ _ _ ___ ___ _-- _ _ ---- --- - - - --- --- _ _ - _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ _ _ _ ___ _ - _ - - _ --- - - _ --- --___ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ ___ ___ _ _ _ ___ ___ _ _ _ _ _ _ ___ _ _ _ ___ ___ ___ _ _ _ ___ ___ _ _ _ _ _ _ ___ ___ ___ _ _ _ _ _ _ ___ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ ___ _ _ _ _ _ _ _-_ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ _ _ _ _._ _ _ _ -__ ...................................................................................................... ...................................................................................................... ...................................................................................................... ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ - - ___ --- --- - - - _ _ -- - - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ - _ __-- _ _--- - _ _.--- _ _--....................................................................................................... _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ - _ _ - _ _ .__

--T

--T

--T

--T

--T

--T

--T --T -G-

G-C

G-C

_.-

-.-

__. -.-

--T

--T --T

_._

_.__._

___ ___ ___ _ _ _ _ _ _ G - - ___ _ _ _ _ _ _ G--

___

_-- _ _ _ --- _-- --- - - - ---

_._

--T --T

--- ---

-A-

.--

--T . _--T _

..- --T

__.

--T

G-C

--.

--.

--.

--.

_-_ _ _ -___ _ _ _ ___ _ _ _ _ - _ - _ - - - ___ _ _ _ _ _ _ ___ _ _ _ ___

--- --- --- ---

_.__ _.-_

_._ --.--- ---

.._ __ --. .__. - - - - - - --- --- - - - - - - --- --__. .__ - - _ --- --- - - - - - - - - --...G - - ................................................................................................. ...G - - .................................... --T . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . __. -A__. .__ A-.

---

___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ ___ _ _ _ ___ _ _ _ ___ ___ ___ ___ ___ G - - -G- _ _ _ ___ _ _ _ _ _ _ ___ ___ ___ --_ ___ --- ___ _-____ ___ ___ ___ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ _ _ _ ___ ___ G - - -G- _ _ _ ___ ___ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ ___ _ _ _ ___ ___ _ _ _ ___ _ _ _ ___ _ _ _ ___ ___ _ _ _ _ _ _ ___ _ _ _ _ _ _ A-- ___ ...G--A- ................................................. ___ -G- _ _ _ ___ ___ _ _ _ ___ ___ --- _-- --- _-- - - _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ - _ __ _ _ - _ _._-- _ __ _ - - _ _ _.......................................................................................... _ _ ___ _ _ _ ___ _ _ _ -m _ _ _ AG- _ _ _ _ _ _ _ _ _ _ - _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ --- ,. --T --T - _ _ ......... ___ ___ ___ _ _ _ _ _ _ --T _ _ _ -C. _ _ _ ___ ___ ___ ___ _ _ _ ___ ___ _ _ _ _ _ _ _ _ _ ___ _ _ _ ___ ___ _ _ _ ___ -.A- --T --T - _ _ ...................................................................................................... ___ ___ __ __ __ ___ _ _ _ ___ ___ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ --- ___ _ _ _ ___ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ --T ___ ___ -T- _ _ _ _ _ _ _ _ _ ___ ___ _ _ - _ _ -- _ __ _ _ ___ ___ -___ _ _ _-_ ___ _ _ _ _ _ _ -c- _ _ _ _ _ _ ___ ___ ___ - _ _ .--- _ _--- - _ _ .......................................................................................................

............................................. A-A--

G--

-A-A-

A-.

_.-

-A-

__.

G--

--.

G--

--A

GA__.

-G-

-C-

--.

..-

-.-

A--

_._

-.-

--.

A--

G--

__. -G-

.__

__.

.A-

Marsh & Bodmer DRB Sequences: DRBl*OlOl DRB1*0102 ORB1 '0103 DRB1.1501 DREl'l502 DRB1.1503 DRB1.1601 DRBI'1602 DRB1'0301 9RB1*0302

DRB1.0303 DRB1.0401 DRBI *o 40 2 DRBl.0403 DRBlgO4O4 DRB1'0 405 DRB1'0406 DRBl'O407 DRB1.0408 DRB1'0409 DRB1-04 10 DRB1'0411 DRB1'0412 DRBl*l1011 DRB1'11012 DRB1*1102 DRBl*lI03 DRB1*11041 DRB1*11042 DRB1.1201 DRB1.1202 DRB1'1301 DRB1'1302 DRB1.1303 DRB1.1304 DRB1.1305 ORB1 '1306 DRB1.1401 DRB1.1402 ORB1 1' 403 DRB1'1404 ORB1 * 1405 DRB1'1406 DRB1.1407 DRBl*l408 DRB1'1409 DRB1'1410 DRB1.0701 DRB1'0702 DRB1'0801 DRB1.08021 DRB1.08022 cRBi*oao1i DRB1'08032 DRB1.0804 DRB1'0805 DRB1'09011 DRB1'09012 DRB1*1001 DRB3'0101 DRB3'0201 DRB3-0202 DRB3.0301 DRB4*0101 DRBS.0 10 1 DRB5*0102 DRB5.0201 DRB5.0202 DRB2 DRB6'JlOl DRB6'0201 DRB6'0202 DRB7 ORB8 DRB9

234

140

150

170

160

ATG C R : GAA ACA C l T CCT CCC A m e m GAG m --_ _-___-___ ___ CTC __---_ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ -_- ___ _ _ _ -_____ -_- _-__-- __---- ___ -__ _-____ ___ ___ ___ -_____ ___ _ _ _ ___ ___ ___ _-____ ___ ___ ___ ___ --A ___ ___ ___ ___ --- -_____ ___ ___ ___ __---_ ___ __-___ ___ ___ - - A ___ ___ ___ ___ ...................................................................................................... --- --- --_ _-- -__A - --- -_____ _ _ _ ___ ___ ___ --_ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ --- --_ --- _-- _-_A - -_____ ___ ___ ___ ___ ___ _-____ ___ ___ ___ ___ --A ___ ___ ___ ___ --- --_ --_ A - - -__ ___ --_ -_____ ___ ___ ___ ___ _-____ ___ ___ ___ ___ ___ ___ ___ ___ ___ --- --- ___ A - - ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ --- --_ --- A - - --_ ___ --- ___ _-___-___ ___ ___ _ - ____ __---_ ___ ___ ___ ___ ___ ___ ___ --- --- --- A - - --- ___ --- --_ --- __--_____ _ - - --- -_- -_- --- --_ __-__-___ ___ ___ ___ --- --_ --_ A - - ___ ___ --- _-__-- __--_____ __---_ __-___ --_ ___ ___ ___ ___ ___ ___ ___ --_ - _ ____ A - - ___ ___ --- - - - _-- --- --- --- --- --- __---C --_ ___ ___ _ _ _ ___ ___ ___ _-____ ___ ___ ___ ___ ___ ___ ___ ___ ___ GAA GAG AAC GCT GCG GTG

--- --- --- --- --- ----- --- --- --- - _ - ----- --- --- _-- -__A---- --- --_ _-- -_- A - -

GTG TCC ACA GGC

--- --- --- ----- --- --- ----- --- --- ----- --- --- ---

CTC A X CAG AAT GCA

=T

--- --- --- ----- --- --- ----- --- --- --C --- --- -_- --C - - - --- --- --- ----- --- -_- --C --- --- _-- --- ----- --- -_- --C --- --- _-- --- ----C --- __---C --_ --_ _-- --- --- --C --- __---C --- --- --- --- --- --- --- --- --- --C --- --- --- --- --- --- --- --- --- --c --- --- --- --- --- --- --- --- --_ --C

---------

-----------------

TGO ACC TTC CAG ACC C R :

-----

...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... - - _ - _ ____ ___ ___ --- --- --- --- --- --- --- --- --- --- _-- --- - _ ____ --- --- --- --- --- --- --- --- ___ _-_-_____ ...................................................................................................... ___ ___ ___ ___ ___ --_ --_ _-- - _ - --- --- --- -_- --- -_____ __-___ ___ __---_ __-_ - _ --- _-- _ _ -___ ___ ___ ___ -_- - _ ____ ___ ___ --- --- _-- --- --- --- --- --- --- --- _-- --- --_ --- --- --- --- --- --- --- --- --- -__--- --- _-_ ...................................................................................................... ....................................................................................................... -__-_____ ___ ___ --- --_ --a --- --- --- --- --- --- --- --- --- - _ _-__-_- --- --- --- --- --- --- --_ --_ --_ ___ ...................................................................................................... _-_-_____ ___ ___ --- --- --- --- --- --- --- --- --- --- _-- --- -__-_- --- --- --- --- --- --- --- --- --- --- --- _-...................................................................................................... ...................................................................................................... A--

--c

A-A--

--C

--c --C

--c

--c

A--

--c

--c

A--

--c

--c

T-C

-c-

...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ _-- ___ ___ ___ _ _ _ _ _ _ ___ ___ ___ ___ ___ _ _ _ ___ ___ _ _ -___ ___ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ ___ _ _ _ ___ _ _ _ _-____ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ __- ___ _ _ _ ...................................................................................................... --C --C

--A --A

.__

___ ___

___ ___ ___ ___ __- - _ ____ --- _-- ___ ___ _ _ _ _ _ _ ___ ___ ___ ___ _ _ _ _ _ _ _ _ _ ___ _ _ _ ___ _ _ _ ___ ...................................................................................................... ___ _ _ _ _ _ _ ___ ___ _ _ _ --- ___ _-- ___ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ _ _ _ ___ ___ ___ _ _ _ ___ _ _ _ _ _ _ ___ ...................................................................................................... _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ __--__ ___ ___ _-- ___ ___ ___ _ _ _ _ _ _ ___ ___ _ _ _ ___ ___ _ _ _ ___ ___ _ - _ ___ _...................................................................................................... _ _ _ _ _ ___ _ _ _ ___ ___ _ _ _ ___ ___ _ _ - - - _ ___ --_ _ - - ___ _ _ _ ___ _ _ _ ___ ___ ___ ___ _ _ _ _ _ _ ___ ___ ___ - _ _ ----- _-_ .__

-c-

.__ -.C

_._ -c-

--C

-T-T-

L-C

-f* ***

--T

_._

--.

--C --C

--A

A--

-A-A-

-A-

-C-

SEZ

... ... ... ... ... .I.

I..

-__

......... ......... ... ...... --_-_ --_---- --- --- _ _ - --- ___ ___ ... ... ... ... ... ... ... ... *.. ...... ... ... ....*... ... ... * . ... ... ... ... ... ... ... ... ...... .*._-... ... ... ... _-- --_ --_ ---____

I..

C..

I..

*.

I..

I..

. I .

. I .

. I .

**.

. I .

1..

. 1

. . I

..I

I..

. . I

. . I

.*.

.*.

..L

I..

.*

..I

i..

* -_- _-_.--___

f..

I..

*I.

l..

I..

r..

..I

..I

..__ li..

1,.

.

..__ I,.

Marsh & Bodmer DRB Sequences: DRB1'0101 DRB1.0102 DRB1.0103 DRB1.1501 DRB1*1502 DRB1.1503 DRB1.1601 DRB1.1602 DRB1.0301 DRB1'0302 DRB1.0303 DRB1.0401 DRB1*0402 DRE1.0403 DRB1.0404 DRB1.0405 DRB1.0406

DRBl'O407 DRBI*O4OB DRBl.0409 DRB1.0410 DRB1.0411 DRB1.0412 DRB1*11011 DRB1.11012 DRB1'1102 DRB1.1103 DRB1-11041 DRB1.11042 DRB1.1201 DRB1.1202 DRBI'1301 DRB1'1302 DRB1.1303 DRB1*1304 DRB1.1305 DRBl.1306 DRBl.1401 0881'1402 DRB1.1403 DRB1.1404 DRBl*l40 5 DRB1.1406 DRB1.1407 DRB1*1408 DRB1-1409 DRB1-1410 DRB1.0701 DRBl-0702 DRB1.0801 DRB1*08021 DRB1*08022 DRB1*08031 DRBl'OB032 DRB1*0804 DRB1-0805 DRBl'09011 DRB1'09012 DRB1-1001 DRB3'0101 DRB3-0201 DRB3.0202 DRB3'0301 DRB4-0101 DRB5'0101 DRB5-0102 DRB5'0201 DRB5-0202 DRB2

- _- - -- __ - - - - - _- _-____ --_ ___ ___

--- -__--1..

1..

--T

-G-

--T --T

-0-G-

...................................................................................................... --- --- --- --- _-- --- --- --- --- --- --- --- --- --- --- --- --- --- ___ _-____ ___ ___ ___ ___ ___ ___ ___ ___ --- ___ -__ ___ ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ....................................................................................................... --T

-G-

-G-

___

___ ___

___ ___ ___ _ _ _ ___ ___ ___ _ _ _

236

--_ ___ ---

_ _ _ ___ _ _ _

___ _ _ _ ___ _ _ _ ___ _ _ _ ___

___ _-____ -___ _ _ --- _--

___ ___ ___ ___ ___ _ _ _ _ _ _ ___ ___ _ _ _ --- --- --_ --- --_ ___ _ _ _ ___ ___ ___ ___ _ _ _ ___ _ _ _ _ _ _ ___ --_ ___ --_ - _ _- _ ...................................................................................................... ___ ___ ___ ___ ___ --- ___ ___ --- __---- _ _ _ --- --- --- --- ___ _ _ _ ___ ___ ___ ___ ___ ___ __-__-_ _ _ --- -_- --- --- --- --...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ___ ... -__ --T --T

T--

T--

.__

.--

--T

f..

___ ...

*.

-__ --A --A --A --A

_...................................................................................................... _ _ ___ ___ _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ ___ A-- ___ - - C ___ _ _ _ ___ _ _ _ -A- _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ -A- _ _ _ C-G - * * _ _ _ _ _ _ --- --T ___ ___ _ _ _ ___ ----_ _ _ A-A _ _ _ -__ --- - _ _ --- ___ ___ _ _ _ ___ _ _ _ ___ _ _ _ ___ _ _ _ _ _ _ --- ___ --- - - _ c - - --- --- --...................................................................................................... __.

-..

DRB7 DRB8 DRB9

___

............... .................. ......... ............... .................. ......... ............... .................. ......... ............... .................. ......... ............... .................. ......... .................. ............... --- ___ --- --- -_---- --___ ___ ___ ___ ___ ......... ............... .................. ___ ___ ___ ___ ___ ___ ___ --- ___ ___ ___ ___ ___ ___ ......... .................. ......... .................. --- -_____ ___ ___ _-- --_ -_- --- --- --- --- --- --- --- --- ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ .*.

.__

HLA Class I1 nucleotide sequences, 1992 DQAI. Sequences:

WA1*05013 WAl'Q60 1

WAl.0302 WA1*0401 WA1.05011 WA1.05012 WA1.05013 WAl*0601

WA1*03012 WA1*0301 WA1'0 4 01

WAl'0101 CQA1.0102 WA1*0103 CQA1*0104 W A l * 02 0 1 WA1*03011 WA1'03012 W A lW302 CQA1*0401 WAl*OSO11 WA1*05012 WA1'05013 tQA1'0601

CAG

--_

CTC AT7

_ _ -_ _ .*

...

.**

**.

___-_- - -C .(If

. . I .

--C --C

... _ __ __ _... _ _ _ ... -

..* ...

-.r*-C _ _ - --C

--C --C --C

--C --C

.*.

--C

-C

.*.

*.*

WAl*OIOl WAl*Ol02 WA1'0103 WA1'0 104 WA1.0201 WAI-O~~I~ WA1'03012 CQA1'0302 WA1'0401 WA1'05011 WA1'05012 WA1'05013 WA1.0601

190

WA1*0101 WA1'0102 WA1'0103 WAl*Ol04 WA1*0201 WA1*03011 WA1*03012 WA1*0302 WAl*OlOl WA1'05011 W A 1 * 05 01 2 WA1*05013 CQAl 0 ' 601

200

_... _ _ _... _ _ _... _ _ ___ _.*. _ _ ___ _ _ _ ___ _,.. _ _ ___ _ _ _ _ _ ___ ___ _ _ _ ___ _ _ _ _ _ _ _ _ _ ___ ___ .,.... .** ... ... _*.. .*. ... ... ... ..* ... ... ... .*. ... ... .* ... .*. ... .* .* .*. .*. ... ... ... *.* ___ __ __ __ A-A - - A _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ __ __ __ __ __ __ _____ _ ___ ___ ___ _____ _ _____ _ .,. ___ _ _ _ ___ ... ___ ... _ _ _ ... _... _ _ _... _ _ _... _ _ _- -_T_ ___ ___ .*. *.* ... .* ... ... ..___ ..* *.. ___ _ _ _ _ _ _ A-A _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ ___ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ - ____ - - _ _ _ _ ___ ___ _ _ _ ___ _ _ _ ___ _ _ _ _ _ _ _____ _ ___ _ _ _ _____ _ __ __ __ _ - _ __ __ __ --A --_ _ _ ___ _... _ _ _... _ _ ___ _ _ _ ___ --A _ _ - --_ _ _ ... ____-___...__ __ ____**._ _ _____ _ ______... _.*._ __ __ ___*.. .,. ... **. .*. ... .*. ... ... .* ... ... ___ ___ ___ - A _ _ _ _ _ _ ___ ... *.* *. ... ___... ___ ___... ___... ... ... ___ ___ ___...___ -... ... .**

_.**_ _ *.f ___ ___ ___ __ __ __ ___

...

,..

GAG CCT GAG ATT CCA GCC CCT ATG TCA GAG cTC ACA GAG ACT GTG GTC TGC GCC CTG GGG TTG W T CTG --T . . 1

11.

( I . .

.I*

..(I

( I . .

__.

.__

_ _ ..__

1..

( I . .

*.I*

(Iff

. . ( I

( 1 .

1..

.(I.

_._

f

ff.

.__ .-_ .--

_._

...

f..

I..

..f

. . I .

.__

*.I

.(I.

.I*.

f,.

ff.

11..

1..

1..

. I .

M A 1* 03 0 2 MAl*04Ol WA1*05011 WA1*05012 DQAl'OSO13 DUA1*0601

237

Marsh & Bodmer DQBl Sequences:

CQB1.0602 DQB1.0603 COBlW604

CQB1'0401 0981*0501 CQBl.0501 CQB1'05031 DpB1.05032 CQB1'0504 CQB1'0601

CQBl.0602 CQB1.0603 0981.0604 LlQB1.0605 CQB1.0606

L481*03032 CQB1.0304 CQB1.0401 DpB1.0402 09B1*0501 WB1.05Oi CQB1'05031 CQB1*05032 DpB1'0504 WB1'0601 DpB1'0602 CQBl*0603 CQB1*0604 Dp01.0605 WB1'0606 WB1*0201 WBI'O301 CQB1.0302 CQBi.03031 09Bl*03032

ACC --A --A

CQB1'0304

-C-02

CCC TAC

___

...... ...... __.

... .__

-C-C-C-C-C-

-T-

_ - - -T-

_-.c-

___ -T-

...... -c-

_-.

_--

.--

- A - CT- A - CI. - A - CT-A- CT-

-C-

-C-C-C-

~pni-04oi DpB1.0402

.--

- A - CT-A-A-A-

- cc 110

CICTCT-

120

110

_...................................................................................................... _ _ ..- - .__ _ _ _ __ ._ --.__ - - - .- - - - -.-- - - - - - - - - _ - - _ - - _._ _ _ _ _ _ _ _ _ _ _._ _ _ _ --c _.. _ _ _ . . _~_ _ ..- .--_ - - ._._ - - .--

CCA TCC AGC ACA CAC CCC CPC M C CAC CAC M C C Z CTG A K TCC TCC GTC ACA CAT l T C TAT CCA ACC CAC ATC A M CTC CCG K C l T T CCC M T CAT CAG --.

...................................................................................................... ...................................................................................................... _____ - __ __ __ _____ -__ __ __ ___ _ _ _ _ _ - _ - - - _ __ - - _ - - _ _ _ _.. _ _ _ __._ _ _ __ __ __ __ __ __ _.._ __ __ __ __ _ _ _ _ _ . _._ _ _ _ _-._. ----_.-_ _ --c .-_ _ _ __ __ __ __ -__-___ - _ __ - - - - - - - - -.-- - - . - _._ _._ .-._ - _ _ - _-- --...................................................................................................... ....................................... ............ .................. ...................................................................................................... ...................................................................................................... _ - --- - _ - - - -___ ___ ___ ___ ___ ___ ___ ___ ___ ___._ __ __ ___ ___ ___ ___ ___ ___ ___ _____ -___ ___ ___ ____ ___ __ -_-_ _ _ _ ___-_ _ _--_ _ _ _ -________ -___ ___ ___ _._ __ __ __ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ __ __ __ ___ ___ ___ ___ __-__ ___._ _ __ __ ___ __-_____._--_- ___._--_--_. ----.-c -_.-__ ___ _ - - _._ _-...................................................................................................... _...................................................................................................... _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ - - _ _ _ _ _ _ _-- _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ _ _ _ _ _ _ _ _ _ _ - - _ _ _ _ - _ ...................................................................................................... _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _-- ___ _ _ _ _ _ _ ___ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ -.. _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ - ~ -

-.-

c.c - - - - - ..-

c--

c - - ........................

c-.

c--

CC-

G.-

.--

.--

.--

-A.

C-C--

--I\ --A

CCGC-

-.. --C

C--

--A

CC-

--C

C--

--A

CC-

--C

--.

. - -- - C

HLA Class I1 nucleotide seqluences, 1992 DQBl Sequences: 150

140

0981'0501 MB1.0502

c4ai-o3032 CQ81*0304 CQB1'0401 CQBlW402

ATG ACT CCC CAG CGT GGA GAT

---

............................................................ ........................ ............... ............................................................ ........................ ............... ___ ___ _____ _ _____ _ _ _ _ ___ ___ ___ ___ ___ -_- _ _ - --- --___ ___ ___ ___ ___ ___ ___ ___ ___ ___ --_ ___ ___ ___ _-_ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ ___ -___ _ ---- --- --- - _ ___ ___ - _ ____ _-- ___ --- ___ ___ ___ ___ ___ ............................................................ ........................ ............... ___ ___ _ _ _ ___ _ _ _ _ - ____ __-___ _-- _ _ _ ___ ___ _ _ ---- _-- --- - _ ___ ___ - _ _ _ _ _ ___ _ _ _ --- ___ ___ ___ ___ ___ ............................................................ ............... ........................ ............................................................ ........................ ............... _ _ _ ___ ___ _ _ _ _ _ _ ___ ___ _ _ _ ___ ___ ___ ___ _-- ___ ___ ___ ___ _-- _-_ --_ ___ ___ --_ ___ ___ _ _ _ ___ _ _ _ - _ ___-___ ___ ___ ___ _ _ _ ___ ___ _ _ _ ___ _ _ _ ___ _-- ___ ___ ___ ___ __- --_ __ __ __ ___ ___ ___ --- ___ ___ _ _ _ ___ ___ ___ ___ ___ _ _ _ ___ ___ _ _ _-- - _ _--- _ _ _ _ - - _-- _-- --_ _ - - --- --- --- -_- - _ __ _ ---- --- --- ___ _ _ _ _ _ _ ........................ ___ _............................................................ ............... ___ ___ ___ ___ ___ __---- _-- -__--- --- _-- --- --- - _ ___-__-_ _ - --_ ___ ___ ___ ___ ___ -__ ___ _............... _ _ ___ ___ ___ ........................ ............................................................ f.. ............................................................ ............... -___ _ _ ___ _-__ _ _ ___ ___ ___ ___ ___ ___ ___ _-__ _ _ -_____ __-_-__-- --_ --- --- --- --- -_- --- _ _ ---_ __---_ --T

CQBlW603 CQBlW604 CQB1.0605 0981'0606 CQBl*0201 WB1*0301 CQB1*0302 CQBl*03031

150

_-__-_--- -_- _-- --_ --- --_ --- _-- CTG _-- GAA --- --- --- --- --- --- --- --___ ___ --- _-- --- --- --- ___ _ _ _ --- --- --- ___ ............................................................ ........................ ...............

GAG GAG ACA GCC CGC GTT GTC TCC ACC CCC CTC ATT AGG AAC GGT GAC TGG ACC TTC CAG ATC CTG GTG ATG

--T A- A-T

--T --T

--T

--T

--T

--T

--T

--T --T --T

--T

-A-

--C

-A-

--C --C -C

--c

--T

A- T

.** *.*

**. * * * ,** *.* * * *

--c

--T

A-T

190 a00 CTC CAG AGC CCC ATC ACC GTG GAG TGG CGG CCT CAG TCT GAA TCT CCC CAG AGC AAG ATG CTG ACT GCC GTT CGA

180

___ -__--........................................................................... ........................................................................... ........................................................................... _ _ _ ----_ ___ ___ ___ _ _ _ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ _-- --_ -____-___ ___ ___ ___ _-_ - _ __-- _ _ -__-___ -_____ ___ --- _-____ __-_ _ _ _-- --_ -_- --- _ _ -_-- _ _ _ ___ ___ ___ ........................................................................... --- --- --- --- --- _ - - - - _ --- ___ _-- _ _ _ _-_- _ ___-_-- _-- --_ --- --- -_- --- _-- --_ ___ -__ ........................................................................... ........................................................................... --- --- --- --- - - - _ - - --_ _ _ - _-_ -___ - - _ _ -_ _ _ - - _ - _ - --- __---- _ _ _ - _ _ ___ ...... .................................................................. _........................................................................... _ _ - _ _ ___ ___ _ _ _ ___ ___ _ _ _ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ _ _ _ ___ ___ ...... ...... ......................................................... ........................................................................... ........................................................................... --- --- --- --- --- _-- --_ --- __- _-- --_ _-- - _ _--- --- --- --- --- --- --- __-___ -A-

a--

-A-A-

-T-

-A-

-T-

_-_- _ _ -A- _-- ___

-T-

210

- _ - ___

_ _ _ ___ --_ -__---

.--

A--

--A

A--

I\--

.--

_ _ _ ___ _ _ _ _ _ _ ___ ___ ___ ___ _ _ _

220

___

___ ___

__.

___ _ _ _ ___ _ _ _

A--

___

230

GGC TTC G'K C% Gw: CTG ATC TTC CTF GCC Cm GGC CTP ATC ATC CGT CAA AGG AGT CGG AAA CCG CTT CTG CAC TGA

..................... ............... .......................................... ..................... ............... .......................................... ...................... ............... .......................................... --- _ _ _ --- _ _ _ --_ ----_ _ __ __ __ __ __ ___ _ _ _ __ __ __ __ __ __ _____ _ __ __ __ __ __ __ __ __ __ __ __ __ _____ _ __ __ __ ___ ___ - - - - - - - -- - - - - - - - - - -- _ _ _ _ - _ ..................... ............... .......................................... _ - - _ _ _ _-____ _ - _ ___ _ _ _ _ _ _ _ - - _ _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ ___ _ _ _ ..................... ............... .......................................... ..................... ............... .......................................... --- - _ _ _ _ _ - - _ _ _ _ _ _ _ ----_ - _ - _ _ _ _ _ _ ___ ___ ___ _ _ _ ___ ___ ___ ..................... ............... .......................................... - - - _ _ _ --- _ _ _ - - _ _ _ _ _ _ _ _-- _ _ _ ___ _ _ _ ___ ___ _ _ _ ..................... ............... ............... .............................. .......................................... ..................... ......... ..................... ............... .......................................... ..................... ............... .......................................... - - - - _ _ --_-_ ----_ - _ __ - ___ ___ ___ ___ ___ ___ ___ .--

_-- _-- - - _ --- - _ __-- --- _-_--_ --- --- _ _ - - - - --- --- --- --- _-- --_ __. --c

--G

.-_ --G

-._ __.

- - G .__

_-.

--c

--G

. __ __ . _..-c _

--G

-A-A-

.__

--C

-A-

-A- --C

_._-A-

-A-

--T

-A-

--C

._.

_._

--C

--c

_ _ . . _.__ _ --c

--G

--T

-A.

--C

_ _ .-A-

--C

239

Marsh & Bodmer DPAl Sequences:

___ _-.*.

GCG DPAl.0201

.* .* .*.

DPA1.0401

DPA1.02021 DPA1+02022 DPAl.0301 DPAl.0401 80 90 CAG CGT TCC AAC CAC ACT CAG GCC ACC AAC GAT CCC CCT GAG GTG ACC GTG TlT CCC AAG GAG

--_ --- --- --- --- --- --- --- --- --- --- --_ --- --_ --_ ___ ___ ___ _ _ _ --- --_ ___ ___ ----- --- --- --- -___ _ _ _ _ _ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ --___ --___ ___ ___ ___ G-- --T ___ ___ _ _ _ _ _ _ ___ ___ _ _ _ ___ ___ ___ ___

DPA1.0101 DPAl.0103 DPAl.0102 DPA1.0201 DPA1'02021 DPA1.02022 DPAl.0301 DPA1.0401

............................................................... ............................................................... ............................................................... ...............................................................

110 120 CAC ATT GAC AAG TTC TTC CCA CCA CTG CTC AAC GTC ACG TGG CTG TGC AAC GCG GAG CTG GTC ACT

___ __--- --- --- --- --- --- --- --- --- --- --_ _-- --- ___ _ _ ---- --- --- --__ __ __ ____ _ _ --___ _-- --_ _ _ ---- --- --- --- - _ ____ _ _ _ _ _ _ ___ _ _ _ _ _ _ ___ ___ _ _ _ _-- _ _ ___ -G- ___ _ _ _ ___ ___ ___ ___ _ _ _ _ _ _ --A _ _ _ _ _ _ ___ --T ___ _ _ _ -CA _ _ _ ___ ..................................................................

DPA1'0201 DPA1.02021 DPAl.02022 OPA1.0301 DPA1.0401 DPA1'0101

DPA1'02022 DPAl 'D3O 1 ,DPA1*0401

.................................................................. .................................................................. ..................................................................

150 160 170 140 TTC CTG CCC AGA ACA GAT TAC AGC TTC CAC RAG 7TC CAT TAC Cn: ACC TTT GTG CCC TCA GCA GAG GAC TTC TAT GAC TGC AGG GTG GAG CAC TGG CCC TTG

_ _ _ _ _ _ _ _ _ _ _ _ _ _ -_ _ _ -_ _- -_ -_ -_ -_ -_ _........................... _ _ ___ _ _ _ _ _ _ _ _ _ _ _ _ ___ ---

--- - - - - - - - - -

........................... ........................... ...........................

- - - - _ _ _ _ _ _ _ _ - - - --- --- - _ __ _ _ - - - _ _ _ _ _ _ ___ _-- --- - - _ _ _ _ ___ ___ --- --_ -__ --- - - - --- ---

_____ _ ___ _ _ _._ __ __ __ __ __ __ __ __ __ _---- --- --- --- --- - - - --- _ _ _ __ __ __ ____ ___ _ _ _ --_ _ -- _ - -_- _ - - --- --- --- - - - _ _ _ _ _ _ _ _ _ _ _ _ _ _ ___ _ _ _ G-- _ - - - - - - - - - - - --- --- - - - --- --- _ _ ...........................................................................

........................................................................... ........................................................................... ...........................................................................

180 190 200 CTC CTC AAG CAC TGG GAG GCC CAA GAG CCA ATC CAG ATG CCT GAG ACA ACC GAG ACT CTG CTC TCT GCC CTG GGC CTG GTG CTG GGC CTA GTC

___ ----_ - ---___ _ _ _ _ _ _ _ _ _ _ _ -_- ___ _ _ _ _ _ _ _ _ - --- - - - _-- --- - - - --- --- - - __ __ __ ___ ___ _ _ _ _-- __ __ __ ___ ___ __ __ __ _- ____ --- - - -c- _ _ _ _ _ _ _ _ _ _ _ - __-___ _ _ _ _ _ _ - _ - --- - - - _ - - _ - - --- - - - --- --_............... _ _ _ _ _ __ __ __ _____ _ _---- _ _ _ ___ ___ _ _ _ __---- - - - - _ __ _ _ _ _ _ ___ _ _ - --_ _ _ _ _ _ _ _ _ _ - _ - --- --- --- --- --- --- --- - - .............................................................................. .__

DPA1.0201 DPA1.02021 DPA1.02022 DPAl.0301 DPA1.0401 DPA1.0101

.............................................................................. ............... ............... .............................................................................. .............................................................................. ............... 210 220 230 GGC TTC ATC G n : GGC ACC GTC CTC A K ATA AAG TCP CTG CGT TCP GGC CAT GAC CCC CCC GCC CAG GGG ACC CTG TGA A-_._ _ _ -- - - ---.- - _ --- --- - - - - - _-- --A-_ _ ---_ --- - - - _-. _ - - - - - --- - - - - - - - - - - - _ _ ---... A-- ........................................................................ .** , . . I f.. .tt .*. .* f

__ __ __ ___ _ _ _ ___ ___ __ __ __ ___ ___ _ _ _ -_- ---

___ ___

_-_

---

............ ... ... .*. ............ ... ... ... ... ..*......... . * ..* ... ... ... *.

I)..

**,

1.1

"*. .* ***

(I**

..*

.**

1..

.I).

f..

1 . 1

***

**.

.** ..*

.*s

(If.

---

___ ___ ___ _ _ _ __ ___ -

.*. ..*... f.. ...... .., .. ... .*. .** ... . * ...... *. ... .* ...

....... * ... ... ... .*. ... ...... ... ... ...... .* ... ......... .*..*. ... ... *.(I

.**

**.

"*. .* 0..

1..

.*

.(I.

.Of

( I . .

f..

-----

--G

HLA Class II nucleotide sequences, 1992 DPBl Sequences: DPB1'0101 DPB1*02011 DPB1'02012 DP91.0202 DPB1*0301 DPBlW401 DPB1.0402 DPB1'0501 DPBl.0601 DPBl'OBOl DPB1*0901 DPB1*1001 DPB1.1101 DPB1*1301 DPB1.1401 DPBl.1501 DPB1'1601 DPB1'1701 DPBl*IBOl DPB1*1901 DPB1*2001 DPB1.2101 DPB1.2201 DPB1-2301 DPB1-2401 DPB1.2501 DPB1.2601 DPB1.2701 DPB1*2901 DPB1.3101 DPB1.3201 DPB1.3601

DPB1*0101 DPB1*02011 DPB1.02012 DPB1'0202 DPB1.0301 DPB1*0401 DPB1.0402 DPB1'0901 DPB1'0601 DPBivaoi DPB1.0901 DPBl*lOOl DPB1.1101 DPB1.1301 DPB1.1401 DPB1*1501 DPB1.1601 DPB1.1101 DPBl.1801 D?B1'1901 DPB1'2001 DPB1-2101 DPB1'2201 DPB1-2301 DPB1*2401 DPB1*2501 DPB1*2601 DPBl.2701 DPB1'2901 DPB1'3101 DPB1-3201. DPB1'3601 100 D~B1'0101 DPB1.02011 DPBl'02012 DPB1-0202 DPB1.0301 DPBl*O4Ol DPB1.0402 DPB1.0501 DPB1'0601 DPBl-OBOl DPB1.0901 DPB1.1001 DPB1.1101 DPB1.1301 DPB1'1401 DPB1-1501 DPBl*1601 DPB1.1701 DPB1-1001 DPB1.1901 DPB1*2001 DPB1'2101 DPBl. 2201 DPBl.2301 DPB1.2401 DPB1.2501 DPB1*2601 DPB1.2701 DPB1*2901 DPB1'3101 DPB1.3201 OPB1*3601

GTC CAG CCT AAG TCC CCC TCC ___ ___ ___ ___ ___ AAC --T ___ ___ _ _ _ _ _ _ ___ _ _ _ ___ ___ ___ --T _ _ _ ___ _ _ _ _ _ _ GTT

GTG

CGA

-G-G-

... ... ... ... .*. ... ___ ___ ___ _ _ _ - _ __ _ _ ___ _ _ _ _ _ _ _ _ ___ ___ ___ _ _ _ ___ ___ ___ __... _ _ ------... ---... ... --- --... ... ... .,. ... ... ..* *.

*.*

___

***

(If.

.*(I

.-.

__.

-G-

.*.

-G*.*

--r --T

*. **. -.*

-.-

.*.

-.-

f..

*.

......... ... ... ...*.. ... ... .... ... ... .* ... * ......... ... ...... ... f.. *.. ... ... *.. ... ... ... ...... ... ...... ... ....,. ... .*. ..* ... ... ... ... ... f.. ... *.. ... ... ... ... ... .* ... ...* * * ..* _ _ _ -..... ... .*. ...... ...... ___ * . .f. _ _ _ .*. *. _...*. ...... ...... ...... ...... ... ___ f...*. ___ .*. ... * . .* ... ... ___ ... * . ... ... _____ _ _.. ... ...... ... ... ... ... ... ... ___ ... ... ...... *. ... _ _ _ ... .*. ... ..* ___ _.. ...... ... ... .*. f..

.**

f..

.*.

I)..

*.

*.

*..

.**

1..

.**

-1.

*.*

( I . .

( I . .

..I)

(1.1

.* .*

.*

.*.

.*.

-.*

.f*

fff

_ f f

***

__.

-.* .**

_f.

.**

-,* -** -**

. ( I .

.*.

.*

( I . .

(If*

*.

0..

.**

. . ( I

**.

*.* *.*

*.

ff.

f..

111.

*.*

ff.

*f.

*.*

1..

1.1

**. *.*

ff.

.*. .*

*.

f..

.*. *.*

f..

f..

111.

*.

I*.

.*

f..

.** .*

.** .*

0..

.*. .*.

.I.

I.*

.I).

.I.

* . I .

**.

* . . I

f..

**. .*. ***

. 1

1..

0..

***

f..

.** .*.

(If.

.*

.**

1..

*.

.** *.*

f..

. ( I .

*** *.*

*.

111.

.**

**.

**.

.I**

* . I )

*.*

f..

.*.

( I . .

**.

*.

*. **. .*

Marsh & Bodmer DPBl Sequences: 110 120 130 oeei-oioi M G AAG u;G CCC CTG CAG CAC CAC M C C'TG CTT GTC TCC CAC GTG ACA GAT TTC TAC CCA GGC ACC ATT C M GTC CGA TGG TFC --_ _ -T-- --------G OPB1*02011 T-- --------G --DPB1*02012 OPB~*OZO~ --- -_- --- _ _ ---- ----- ------- --OP81*0301 T---- --_ ----- _-- --G OP81*0401 T-- ----- --_ --- --- ----G OPB1*0402 OPBI'OSOI OP81'0601 OPBl'OBOl OP81*0901 OPBl*lOOl DPB1'1101 OPB1*1301 OPBl*l4Ol DPB1.1501 OPB1*1601 DP8l* 1701

--- --- --- --- --- --- --- ___ -_____ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ----- --- --- --___ ___ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ....................................................................................................... ___ --- --- --- ----- --_ -_____ _-- ___ --_ _ _ _ ___ ___ ___ __-___ ___ ___ ___ ___ ___ ___ ___ ___ -_- ___ ___ --- --_ ----- ___ _ _ _ ___ ___ ___ ___ _ _ _ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ __--- --- --- --- ___ -_____ _-____ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___ ___

___

--- --_ -__ _-- ___ ___

AAT GGA CAG GAG GAA

___.

...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ................................ .................................................................. ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... ...................................................................................................... .............. .................................................................................... 4...

OP81'2101 OPB1*2201 OPB1.2301 OPBl'2401 OP81.2501 OPB1'2601 OPB1*2701 OPB1'2901 0PB1.3101 OP81*3201 OP81'3601

...................................................................................................... ...................................................................................................... ...................................................................................................... --- --- --- _-____ --- ___ --- --_ --- --- --- --- --- __---- --- __---- --- ___ ___ --_ __---- ___ --_ _-- ___ --- --- -__-c--- --- --- _--___ --- __---- --_ --- --- --- --- --- --- --- _-- ___ --- --_ ___ ___ --_ __---- -____---- ___ --- --- -_.-I.*

150

140

OPB1*0101 OPB1*02011 OPBl'02012 DPB1'0202 DP81*0301 OP81*0401 OP81'0402 OP81*0501 OP81.0601 DPB1-0801 OP81'0901 OP81*1001 OPBI*llOl OP81'1301

DPBl*1101 DPBI-leol OPB1*1901 DPB1*2001 OPB1.2301 0PB1.2401 DPB1.2501 OP81.2601 OP81.2701 OPB1'2801 OPB1-2901 DP81'3101 OP81.3201 DP81*3601

ACA GCT GGG GTC CTG TCC ACC AAC CTG

ATC

CGT M T

DPB1*2001 OPBl 2 101 DP81'2201 OPB1'2301 DP81.2401 OP81*2501 OPB1.2601 OP01'2701 DPB1'2901 OPB1'3101 OP81*3201 DPB1.3601 f

GAC TGG ACC TTC

110

160

Cffi

ATC CTG GTG ATG CTG

..................................................................... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ................ *. ...................................................... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ............... ...................................................... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ...................................................... ............... ............... ...................................................... .....................................................................

GAA ATG ACC

CCC CAG CAC

GGA

GAC GTC TAC ATC --T --T -C-

.................................

--- --- --- _-- --- --- -_---- -__--- --- ----- --- --- --- --- --- --- --- _-_--_ -_- --- --- --- --- -__--- --- --- --- ----- --- --- _-- ___ --- ___ --- --_ --- --- --- --- --- --- -_- --- ___ --- ___ ___ ___ ___ ___ ___ -_____ _-- -___-- --T _-____