Longenecker et al. BMC Nephrology (2017) 18:103 DOI 10.1186/s12882-017-0518-5

RESEARCH ARTICLE

Open Access

Hyperuricemia after orthotopic liver transplantation: divergent associations with progression of renal disease, incident endstage renal disease, and mortality Joseph C. Longenecker1,2, Sana Waheed3, Ghassan Bandak4, Christine A. Murakami5, Blaithin A. McMahon2, Allan C. Gelber2 and Mohamed G. Atta2*

Abstract Background: Although hyperuricemia is common after orthotopic liver transplantation (OLT), its relationship to mortality, progressive kidney disease, or the development of end stage renal disease (ESRD) is not well-described. Methods: Data from 304 patients undergoing OLT between 1996 and 2010 were used to assess the association of mean serum uric acid (UA) level in the 3-months post-OLT with mortality, doubling of creatinine, and ESRD incidence. Post-OLT survival to event outcomes according to UA level and eGFR was assessed using the Kaplan Meier method and multivariate Cox proportional hazards models. Results: Mean UA level among the 204 patients with an eGFR level ≥60 ml/min/1.73 m2 was 6.4 mg/dl compared to 7.9 mg/dl among the 100 patients with eGFR

Hyperuricemia after orthotopic liver transplantation: divergent associations with progression of renal disease, incident end-stage renal disease, and mortality.

Although hyperuricemia is common after orthotopic liver transplantation (OLT), its relationship to mortality, progressive kidney disease, or the devel...
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