J Complement Integr Med. 2014; 11(3): 179–183
Awanish K. Pandey*, Prem P. Gupta and Vijay K. Lal
Hypoglycemic effect of Rhizophora mucronata in streptozotocin induced diabetic rats Abstract: Rhizophora mucronata, plant of Mangroove family, found on the coastal region of India and used in treatment of various diseases. Different parts of plants are used in treatment of diabetes as folkloric medicine. The present study was designed to evaluate the hypoglycemic effect of hydro-alcoholic extract of R. mucronata. Streptozotocin (STZ)-induced diabetic rats were treated with RME (100 mg/kg and 200 mg/kg) and glibenclamide (0.5 mg/kg). Blood glucose levels were evaluated for the acute and sub-acute studies and body weight of rats were also monitored. All the treatments showed the highly significant (p200 mg\dL. Control and diabetic rats were weighed matched for body weight and divided into following groups consisting of six animals each. Group I – Non-diabetic control Group II – Diabetic control Group III –Diabetic rats administered with R. mucronata extract (RME) in dose of 100 mg/kg Group IV – Diabetic rats administered with RME in dose of 200 mg/kg Group V – Diabetic rats administered with glibenclamide at dose of (0.5 mg/kg) The acute study involved estimation of blood glucose levels at 0, 2, 4, 6, and 24 h after administration of glibenclamide and RME.
The chronic study involved daily administration of glibenclamide and RME for 28 days, and blood glucose levels were estimated on 0, 7,14, 21, and 28 days. Blood glucose estimation – Blood samples were obtained through puncture tail vein, and collected blood samples were analyzed by Accu-Check Glucometer. Blood glucose levels were expressed in terms of mg\dL. Body weight determination – Weight of rats was recorded before and after the study period of 28 days. Percentage change in body weight was calculated and graphs were plotted. Statistical analysis – Result were expressed as mean ±SEM. Statistical analysis was carried out by using oneway analysis of variance followed by Dunnet test. Values of p
Awanish K. Pandey*, Prem P. Gupta and Vijay K. Lal
Hypoglycemic effect of Rhizophora mucronata in streptozotocin induced diabetic rats Abstract: Rhizophora mucronata, plant of Mangroove family, found on the coastal region of India and used in treatment of various diseases. Different parts of plants are used in treatment of diabetes as folkloric medicine. The present study was designed to evaluate the hypoglycemic effect of hydro-alcoholic extract of R. mucronata. Streptozotocin (STZ)-induced diabetic rats were treated with RME (100 mg/kg and 200 mg/kg) and glibenclamide (0.5 mg/kg). Blood glucose levels were evaluated for the acute and sub-acute studies and body weight of rats were also monitored. All the treatments showed the highly significant (p200 mg\dL. Control and diabetic rats were weighed matched for body weight and divided into following groups consisting of six animals each. Group I – Non-diabetic control Group II – Diabetic control Group III –Diabetic rats administered with R. mucronata extract (RME) in dose of 100 mg/kg Group IV – Diabetic rats administered with RME in dose of 200 mg/kg Group V – Diabetic rats administered with glibenclamide at dose of (0.5 mg/kg) The acute study involved estimation of blood glucose levels at 0, 2, 4, 6, and 24 h after administration of glibenclamide and RME.
The chronic study involved daily administration of glibenclamide and RME for 28 days, and blood glucose levels were estimated on 0, 7,14, 21, and 28 days. Blood glucose estimation – Blood samples were obtained through puncture tail vein, and collected blood samples were analyzed by Accu-Check Glucometer. Blood glucose levels were expressed in terms of mg\dL. Body weight determination – Weight of rats was recorded before and after the study period of 28 days. Percentage change in body weight was calculated and graphs were plotted. Statistical analysis – Result were expressed as mean ±SEM. Statistical analysis was carried out by using oneway analysis of variance followed by Dunnet test. Values of p
