Veterinary World, EISSN: 2231-0916 Available at www.veterinaryworld.org/Vol.9/February-2016/2.pdf
RESEARCH ARTICLE Open Access
Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats K. Kavitha1, A. Gopala Reddy1, K. Kondal Reddy2, C. S. V. Satish Kumar1, G. Boobalan1 and K. Jayakanth1 1. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Hyderabad - 500 030, Telangana, India; 2. Department of Livestock Products Technology, College of Veterinary Science, Hyderabad - 500 030, Telangana, India. Corresponding author: K. Kavitha, e-mail: [email protected], AGR: [email protected], KKR: [email protected], CSVSK: [email protected], GB: [email protected], KJ: [email protected] Received: 15-07-2015, Revised: 10-12-2015, Accepted: 19-12-2015, Published online: 03-02-2016 doi: 10.14202/vetworld.2016.118-122 How to cite this article: Kavitha K, Reddy AG, Reddy KK, Kumar CSVS, Boobalan G, Jayakanth K (2016) Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats, Veterinary World 9(2): 118-122.
Abstract Aim: The objective of the study was to assess the effect of combination treatment of insulin, pioglitazone and synbiotic on streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetes mellitus was induced chemically by intraperitoneal administration of STZ (40 mg/kg b.wt) to male Sprague-Dawley rats. The rats were divided randomly into six groups of six rats in each. Group 1 was maintained as a normal control. Group 2 was maintained as diabetic control; Group 3 was treated with insulin; Group 4 with insulin + synbiotic; Group 5 with insulin + pioglitazone; and Group 6 with insulin + synbiotic + pioglitazone. All the animals were treated for 60 days. Results: Body weights, and concentration of reduced glutathione (GSH), and high-density lipoproteins cholesterol were significantly (p
RESEARCH ARTICLE Open Access
Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats K. Kavitha1, A. Gopala Reddy1, K. Kondal Reddy2, C. S. V. Satish Kumar1, G. Boobalan1 and K. Jayakanth1 1. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Hyderabad - 500 030, Telangana, India; 2. Department of Livestock Products Technology, College of Veterinary Science, Hyderabad - 500 030, Telangana, India. Corresponding author: K. Kavitha, e-mail: [email protected], AGR: [email protected], KKR: [email protected], CSVSK: [email protected], GB: [email protected], KJ: [email protected] Received: 15-07-2015, Revised: 10-12-2015, Accepted: 19-12-2015, Published online: 03-02-2016 doi: 10.14202/vetworld.2016.118-122 How to cite this article: Kavitha K, Reddy AG, Reddy KK, Kumar CSVS, Boobalan G, Jayakanth K (2016) Hypoglycemic, hypolipidemic and antioxidant effects of pioglitazone, insulin and synbiotic in diabetic rats, Veterinary World 9(2): 118-122.
Abstract Aim: The objective of the study was to assess the effect of combination treatment of insulin, pioglitazone and synbiotic on streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetes mellitus was induced chemically by intraperitoneal administration of STZ (40 mg/kg b.wt) to male Sprague-Dawley rats. The rats were divided randomly into six groups of six rats in each. Group 1 was maintained as a normal control. Group 2 was maintained as diabetic control; Group 3 was treated with insulin; Group 4 with insulin + synbiotic; Group 5 with insulin + pioglitazone; and Group 6 with insulin + synbiotic + pioglitazone. All the animals were treated for 60 days. Results: Body weights, and concentration of reduced glutathione (GSH), and high-density lipoproteins cholesterol were significantly (p
