Eur J Orthop Surg Traumatol DOI 10.1007/s00590-017-2054-1
ORIGINAL ARTICLE • GENERAL ORTHOPAEDICS - INFECTION
Hypokalemia during antibiotic treatment for bone and joint infections Carmen Falcone1 · Leonida Compostella2 · Antonella Camardo1 · Li Van Stella Truong2 · Francesco Centofanti1
Received: 4 July 2017 / Accepted: 8 October 2017 © Springer-Verlag France SAS 2017
Abstract Purpose During treatment of bone and joint infections (BJIs) with multiple antibiotic therapy, hypokalemia has been reported as a rare side effect. The aim of this study was to evaluate incidence and risk factors for hypokalemia in a cohort of patients treated with multidrug therapy for BJIs, in a single center. Methods We retrospectively reviewed 331 clinical files of 150 consecutive patients (65% males; median age 59 years, 95% CI 55–62) admitted repeatedly to our Osteomyelitis Department for treatment of chronic BJIs. Besides surgical debridement, patients received a combination of oral and intravenous antibiotics. Routine laboratory tests were performed at admittance and repeated at least weekly. Possible hypokalemia risk factors were recorded and analyzed. Results Progressive kalemia reduction occurred in > 39% of patients during hospitalization; prevalence of marked hypokalemia (K +
ORIGINAL ARTICLE • GENERAL ORTHOPAEDICS - INFECTION
Hypokalemia during antibiotic treatment for bone and joint infections Carmen Falcone1 · Leonida Compostella2 · Antonella Camardo1 · Li Van Stella Truong2 · Francesco Centofanti1
Received: 4 July 2017 / Accepted: 8 October 2017 © Springer-Verlag France SAS 2017
Abstract Purpose During treatment of bone and joint infections (BJIs) with multiple antibiotic therapy, hypokalemia has been reported as a rare side effect. The aim of this study was to evaluate incidence and risk factors for hypokalemia in a cohort of patients treated with multidrug therapy for BJIs, in a single center. Methods We retrospectively reviewed 331 clinical files of 150 consecutive patients (65% males; median age 59 years, 95% CI 55–62) admitted repeatedly to our Osteomyelitis Department for treatment of chronic BJIs. Besides surgical debridement, patients received a combination of oral and intravenous antibiotics. Routine laboratory tests were performed at admittance and repeated at least weekly. Possible hypokalemia risk factors were recorded and analyzed. Results Progressive kalemia reduction occurred in > 39% of patients during hospitalization; prevalence of marked hypokalemia (K +
