JBMR
ORIGINAL ARTICLE
Hyponatremia and Fractures: Findings From the MrOS Study Sophie A Jamal,1 Spyridon Arampatzis,2 Stephanie Litwack Harrison,3 Roxana C Bucur,1 Kristine Ensrud,4,5,6 Eric S Orwoll,7 and Douglas C Bauer8,9 1
Women’s College Research Institute, University of Toronto, Toronto, ON, Canada Department of Nephrology, Hypertension, and Clinical Pharmacology, University Hospital Bern (Inselspital), University of Bern, Bern, Switzerland 3 Research Institute, California Pacific Medical Center, San Francisco, CA, USA 4 Department of Medicine, University of Minnesota, Minneapolis, MN, USA 5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA 6 Center for Chronic Disease Outcomes Research VA Health Care System, Minneapolis, MN, USA 7 Bone and Mineral Section, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA 8 Department of Medicine, University of California, San Francisco, San Francisco, CA, USA 9 Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA 2
ABSTRACT Hyponatremia may be a risk factor for fracture. To determine the relationship between hyponatremia and fracture we conducted cross-sectional and longitudinal analyses using data from the Osteoporotic Fractures in Men (MrOS) study. The MrOS study enrolled 5122 community dwelling men aged 65 years from six centers across the United States. We excluded men taking bisphosphonates, those with unknown medication history, those without serum sodium measures, or those with out of range assays for serum sodium. Serum sodium was measured at study entry. Subjects were followed for fractures (nonspine [including hip], hip, incident morphometric, and prevalent morphometric) for up to 9 years. We used Cox proportional hazards models to analyze the association between serum sodium levels (
ORIGINAL ARTICLE
Hyponatremia and Fractures: Findings From the MrOS Study Sophie A Jamal,1 Spyridon Arampatzis,2 Stephanie Litwack Harrison,3 Roxana C Bucur,1 Kristine Ensrud,4,5,6 Eric S Orwoll,7 and Douglas C Bauer8,9 1
Women’s College Research Institute, University of Toronto, Toronto, ON, Canada Department of Nephrology, Hypertension, and Clinical Pharmacology, University Hospital Bern (Inselspital), University of Bern, Bern, Switzerland 3 Research Institute, California Pacific Medical Center, San Francisco, CA, USA 4 Department of Medicine, University of Minnesota, Minneapolis, MN, USA 5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA 6 Center for Chronic Disease Outcomes Research VA Health Care System, Minneapolis, MN, USA 7 Bone and Mineral Section, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA 8 Department of Medicine, University of California, San Francisco, San Francisco, CA, USA 9 Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA 2
ABSTRACT Hyponatremia may be a risk factor for fracture. To determine the relationship between hyponatremia and fracture we conducted cross-sectional and longitudinal analyses using data from the Osteoporotic Fractures in Men (MrOS) study. The MrOS study enrolled 5122 community dwelling men aged 65 years from six centers across the United States. We excluded men taking bisphosphonates, those with unknown medication history, those without serum sodium measures, or those with out of range assays for serum sodium. Serum sodium was measured at study entry. Subjects were followed for fractures (nonspine [including hip], hip, incident morphometric, and prevalent morphometric) for up to 9 years. We used Cox proportional hazards models to analyze the association between serum sodium levels (
