Accepted Manuscript Hysteroscopic endometrial resection versus laparoscopic supracervical hysterectomy for abnormal uterine bleeding: long term follow-up of a prospective randomized trial Errico Zupi, MD, Gabriele Centini, MD, Lucia Lazzeri, MD PhD, Andrea Finco, MD, Caterina Exacoustos, MD PhD, Karolina Afors, MD, Fulvio Zullo, MD, Felice Petraglia, MD PII:

S1553-4650(15)00288-5

DOI:

10.1016/j.jmig.2015.04.004

Reference:

JMIG 2540

To appear in:

The Journal of Minimally Invasive Gynecology

Received Date: 16 February 2015 Revised Date:

2 April 2015

Accepted Date: 3 April 2015

Please cite this article as: Zupi E, Centini G, Lazzeri L, Finco A, Exacoustos C, Afors K, Zullo F, Petraglia F, Hysteroscopic endometrial resection versus laparoscopic supracervical hysterectomy for abnormal uterine bleeding: long term follow-up of a prospective randomized trial, The Journal of Minimally Invasive Gynecology (2015), doi: 10.1016/j.jmig.2015.04.004. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT

Zupi

Hysteroscopic endometrial resection versus laparoscopic supracervical hysterectomy for abnormal

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uterine bleeding: long term follow-up of a prospective randomized trial

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Authors:

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Errico ZUPI1, MD, Gabriele CENTINI1, MD, Lucia LAZZERI1, MD PhD, Andrea FINCO2, MD,

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Caterina EXACOUSTOS2, MD PhD, Karolina AFORS3 MD, Fulvio ZULLO4 MD, and Felice

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PETRAGLIA1 MD

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Department of Molecular and Developmental Medicine, University of Siena, Italy

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Department of Biomedicine and Prevention, Obstetrics and Gynecological Clinic, University of

Rome ‘‘Tor Vergata,’’ Rome

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SC

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IRCAD, Strasbourg, France

Department of Obstetrics and Gynecology, University “Magna Graecia” Catanzaro

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The authors report no conflict of interest

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Corresponding author:

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Errico Zupi: email: [email protected], Address: Obstetric and gynaecology, AOUS, Viale Bracci 16,

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53100 Siena, Italy. Tel: +39 0577 586607.

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Words count: 2.270

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Running title: Subtotal hysterectomy versus endometrial ablation: a 15-years follow up

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ACCEPTED MANUSCRIPT

Zupi

Abstract:

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Objective: To compare long-term efficacy of laparoscopic supracervical hysterectomy (LSH) and

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hysteroscopic endometrial ablation (HEA) in treating persistent abnormal uterine bleeding.

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Design: Canadian task force II-2

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Setting: University hospital

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Patients: 153 women treated for abnormal uterine bleeding by LSH or HEA

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Intervention: long-term follow–up assessment of reintervention-rate and quality of life (QoL) using the

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Quality Metric’s Health Survey Short Form 12.

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Measurement and main results: this study is the long term follow-up of a randomized control trial

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conducted in 2003 comparing LSH and HEA in term of reoperation rate and QoL.

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Starting from November 2010 all the patients included in the first trial were invited to participate to this

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study and clinically evaluated through vaginal examination and transvaginal ultrasound. After a mean

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follow up of 14.4 year the 29 % (20/71) of the patients treated with HEA underwent further surgery

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while no patients following LSH had symptoms recurrence. The re-intervention rate was significantly

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higher in the HEA group (P