Diseases 146–151 Diseases of of the the Esophagus Esophagus (2016) (2014) 29, ••, ••–•• DOI: DOI: 10.1111/dote.12316 10.1111/dote.12316

Original article

Changes in modified Glasgow prognostic score after neoadjuvant chemotherapy is a prognostic factor in clinical stage II/III esophageal cancer Yasunori Otowa,1 Tetsu Nakamura,1 Gosuke Takiguchi,1 Ayako Tomono,1 Masashi Yamamoto,1 Shingo Kanaji,1 Tatsuya Imanishi,1 Satoshi Suzuki,1 Kenichi Tanaka,1 Tomoo Itoh,2 Yoshihiro Kakeji1 Division of Gastrointestinal Surgery, Department of Surgery and 2Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan

1

SUMMARY. The inflammation-based modified Glasgow prognostic score (mGPS) has been shown to be a prognostic factor for esophageal cancer, but its changes in relation to neoadjuvant chemotherapy (NAC) have never been discussed. The purpose of this study was to evaluate the potential prognostic role of mGPS with regard to NAC. mGPS was evaluated on the basis of admission blood samples taken before chemotherapy and before surgery. Patients with elevated C-reactive protein (CRP) serum levels (>10 mg/L) and hypoalbuminemia (