J Cancer Res Clin Oncol DOI 10.1007/s00432-014-1674-7
Original Article – Clinical Oncology
IL‑17F gene polymorphism is associated with susceptibility to acute myeloid leukemia Tomasz Wróbel · Katarzyna Ge˛bura · Barbara Wysoczan´ska · Boz˙ena Jaz´wiec · Olga Dobrzyn´ska · Grzegorz Mazur · Kazimierz Kuliczkowski · Katarzyna Bogunia‑Kubik
Received: 21 March 2014 / Accepted: 4 April 2014 © The Author(s) 2014. This article is published with open access at Springerlink.com
Abstract Purpose Recent studies have suggested that Th17 cells may play a role in the pathogenesis of acute myeloid leukemia (AML). This subset of CD4+ cells is characterized by interleukin (IL)-17A and IL-17F production, which share strong homology, and surface expression of the IL-23 receptor (IL-23R). The present study aimed to determine the association between the polymorphic features located within the IL-17A, IL-17F and IL-23R genes and disease susceptibility, progression and response to therapy. In addition, the relationship between the polymorphic variants and the plasma IL-17 levels in patients was analyzed. Methods For this purpose, 187 individuals of Polish origin including 62 AML patients and 125 healthy controls were typed for IL-17A (rs2275913; G-197A), IL-17F (rs763780; A7488G; His161Arg) and IL-23R (rs11209026, G1142A; Arg381Gln) alleles. Results The rs763780 IL-17F polymorphism appeared to be associated with susceptibility to the disease. The presence of the minor (G) variant (RR = 4.76, p
Original Article – Clinical Oncology
IL‑17F gene polymorphism is associated with susceptibility to acute myeloid leukemia Tomasz Wróbel · Katarzyna Ge˛bura · Barbara Wysoczan´ska · Boz˙ena Jaz´wiec · Olga Dobrzyn´ska · Grzegorz Mazur · Kazimierz Kuliczkowski · Katarzyna Bogunia‑Kubik
Received: 21 March 2014 / Accepted: 4 April 2014 © The Author(s) 2014. This article is published with open access at Springerlink.com
Abstract Purpose Recent studies have suggested that Th17 cells may play a role in the pathogenesis of acute myeloid leukemia (AML). This subset of CD4+ cells is characterized by interleukin (IL)-17A and IL-17F production, which share strong homology, and surface expression of the IL-23 receptor (IL-23R). The present study aimed to determine the association between the polymorphic features located within the IL-17A, IL-17F and IL-23R genes and disease susceptibility, progression and response to therapy. In addition, the relationship between the polymorphic variants and the plasma IL-17 levels in patients was analyzed. Methods For this purpose, 187 individuals of Polish origin including 62 AML patients and 125 healthy controls were typed for IL-17A (rs2275913; G-197A), IL-17F (rs763780; A7488G; His161Arg) and IL-23R (rs11209026, G1142A; Arg381Gln) alleles. Results The rs763780 IL-17F polymorphism appeared to be associated with susceptibility to the disease. The presence of the minor (G) variant (RR = 4.76, p
