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Human Vaccines & Immunotherapeutics Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/khvi20
Immune response following postexposure rabies prophylaxis Hasan Tahsin Gozdas
a
a
Department of Infectious Diseases and Clinical Microbiology; Dr. Münif İslamoğlu Kastamonu State Hospital; Kastamonu, Turkey Accepted author version posted online: 06 Apr 2015.
Click for updates To cite this article: Hasan Tahsin Gozdas (2015): Immune response following postexposure rabies prophylaxis, Human Vaccines & Immunotherapeutics, DOI: 10.1080/21645515.2015.1026525 To link to this article: http://dx.doi.org/10.1080/21645515.2015.1026525
Disclaimer: This is a version of an unedited manuscript that has been accepted for publication. As a service to authors and researchers we are providing this version of the accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proof will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to this version also.
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Immune response following postexposure rabies prophylaxis Hasan Tahsin Gozdas Department of Infectious Diseases and Clinical Microbiology; Dr. Münif İslamoğlu Kastamonu State Hospital; Kastamonu, Turkey
Downloaded by [UQ Library] at 12:17 14 June 2015
*Correspondence to: Hasan Tahsin Gozdas; Email: [email protected]
1
I read the recently published article in your journal by Peng et al.1 with great interest. The authors described an interesting case of acute disseminated encephalomyelitis following postexposure rabies prophylaxis. However, I have some comments on this article. Comparison of rabies antibody responses of control group and this case was shown in figure 2. According to this figure, antibody responses were compared beginning from day 14. However, corticosteroids were started to be used beginning from day 7. However, protective antibody response of rabies vaccination begins at day 7.2 So, it could be more appropriate if comparison of the groups should be made beginning from day 7.
Downloaded by [UQ Library] at 12:17 14 June 2015
Antibody response to rabies vaccination decreases with advanced age.3 Their case is a 73-year-old man. This point should be considered as a confounding factor which can inversely affect antibody response to rabies vaccination. The authors concluded that steroids definitely had suppressed production of RVNA. It is very difficult to make such a conclusion with only a single case. It can rather be concluded that steroids did not have a significant negative effect on the production of RVNA in this case.
2
References: 1. Peng J, Chen L, Zhu ZG, Zhu ZR, Hu Q, Fang Y. Effect of Corticosteroids on RVNA production of a patient with acute disseminated encephalomyelitis following rabies vaccination as well as administration of HRIG. Hum Vaccin Immunother. 2014;10:3622-6. 2. Johnson N, Cunningham AF, Fooks AR. The immune response to rabies virus
infection and vaccination. Vaccine. 2010;28:3896-901.
Downloaded by [UQ Library] at 12:17 14 June 2015
3. Mastroeni I, Vescia N, Pompa MG, Cattaruzza MS, Marini GP, Fara GM. Immune response of the elderly to rabies vaccine. Vaccine 1994;12:518-20.
3
Human Vaccines & Immunotherapeutics Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/khvi20
Immune response following postexposure rabies prophylaxis Hasan Tahsin Gozdas
a
a
Department of Infectious Diseases and Clinical Microbiology; Dr. Münif İslamoğlu Kastamonu State Hospital; Kastamonu, Turkey Accepted author version posted online: 06 Apr 2015.
Click for updates To cite this article: Hasan Tahsin Gozdas (2015): Immune response following postexposure rabies prophylaxis, Human Vaccines & Immunotherapeutics, DOI: 10.1080/21645515.2015.1026525 To link to this article: http://dx.doi.org/10.1080/21645515.2015.1026525
Disclaimer: This is a version of an unedited manuscript that has been accepted for publication. As a service to authors and researchers we are providing this version of the accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proof will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to this version also.
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Immune response following postexposure rabies prophylaxis Hasan Tahsin Gozdas Department of Infectious Diseases and Clinical Microbiology; Dr. Münif İslamoğlu Kastamonu State Hospital; Kastamonu, Turkey
Downloaded by [UQ Library] at 12:17 14 June 2015
*Correspondence to: Hasan Tahsin Gozdas; Email: [email protected]
1
I read the recently published article in your journal by Peng et al.1 with great interest. The authors described an interesting case of acute disseminated encephalomyelitis following postexposure rabies prophylaxis. However, I have some comments on this article. Comparison of rabies antibody responses of control group and this case was shown in figure 2. According to this figure, antibody responses were compared beginning from day 14. However, corticosteroids were started to be used beginning from day 7. However, protective antibody response of rabies vaccination begins at day 7.2 So, it could be more appropriate if comparison of the groups should be made beginning from day 7.
Downloaded by [UQ Library] at 12:17 14 June 2015
Antibody response to rabies vaccination decreases with advanced age.3 Their case is a 73-year-old man. This point should be considered as a confounding factor which can inversely affect antibody response to rabies vaccination. The authors concluded that steroids definitely had suppressed production of RVNA. It is very difficult to make such a conclusion with only a single case. It can rather be concluded that steroids did not have a significant negative effect on the production of RVNA in this case.
2
References: 1. Peng J, Chen L, Zhu ZG, Zhu ZR, Hu Q, Fang Y. Effect of Corticosteroids on RVNA production of a patient with acute disseminated encephalomyelitis following rabies vaccination as well as administration of HRIG. Hum Vaccin Immunother. 2014;10:3622-6. 2. Johnson N, Cunningham AF, Fooks AR. The immune response to rabies virus
infection and vaccination. Vaccine. 2010;28:3896-901.
Downloaded by [UQ Library] at 12:17 14 June 2015
3. Mastroeni I, Vescia N, Pompa MG, Cattaruzza MS, Marini GP, Fara GM. Immune response of the elderly to rabies vaccine. Vaccine 1994;12:518-20.
3
