Kozakova et al. Cardiovasc Diabetol (2017) 16:78 DOI 10.1186/s12933-017-0557-z
Cardiovascular Diabetology
ORIGINAL INVESTIGATION
Open Access
Impact of glycemic control on aortic stiffness, left ventricular mass and diastolic longitudinal function in type 2 diabetes mellitus Michaela Kozakova1,2, Carmela Morizzo3, Alan G. Fraser4 and Carlo Palombo3*
Abstract Background: Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients with type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening were suggested to participate on deterioration of diastolic function. The present study investigated the inter-relationships between glycemic control, early diastolic and systolic longitudinal velocity of mitral annulus, LV mass and aortic stiffness in T2DM patients free of cardiovascular disease and with preserved LV ejection fraction, and compared them with those observed in healthy volunteers of similar age and sex distribution. Methods: 125 T2DM patients and 101 healthy volunteers underwent noninvasive measurement of systolic (s′) and early diastolic (e′) velocities of mitral annulus, LV mass, carotid-femoral pulse wave velocity (cfPWV) and local carotid blood pressure (BP). Results: Forty-four (35.2%) T2DM patients had e′ velocity lower than that expected for age (against 7.9% in healthy volunteers; P
Cardiovascular Diabetology
ORIGINAL INVESTIGATION
Open Access
Impact of glycemic control on aortic stiffness, left ventricular mass and diastolic longitudinal function in type 2 diabetes mellitus Michaela Kozakova1,2, Carmela Morizzo3, Alan G. Fraser4 and Carlo Palombo3*
Abstract Background: Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients with type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening were suggested to participate on deterioration of diastolic function. The present study investigated the inter-relationships between glycemic control, early diastolic and systolic longitudinal velocity of mitral annulus, LV mass and aortic stiffness in T2DM patients free of cardiovascular disease and with preserved LV ejection fraction, and compared them with those observed in healthy volunteers of similar age and sex distribution. Methods: 125 T2DM patients and 101 healthy volunteers underwent noninvasive measurement of systolic (s′) and early diastolic (e′) velocities of mitral annulus, LV mass, carotid-femoral pulse wave velocity (cfPWV) and local carotid blood pressure (BP). Results: Forty-four (35.2%) T2DM patients had e′ velocity lower than that expected for age (against 7.9% in healthy volunteers; P
