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Crit Care Med. Author manuscript; available in PMC 2017 November 01. Published in final edited form as: Crit Care Med. 2016 November ; 44(11): 2052–2059. doi:10.1097/CCM.0000000000001857.

Impact Of Weight Extremes on Clinical Outcomes In Pediatric Acute Respiratory Distress Syndrome Shan L Ward, MD1, Virginia Gildengorin, PhD2, Stacey L Valentine, MD, MPH3, Anil Sapru, MD1, Martha A.Q Curley, RN, PhD4, Neal Thomas, MD, MSc5, Douglas F Willson, MD6, and Heidi R Flori, MD7 1Department

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of Pediatrics, Division of Critical Care, UCSF Benioff Children’s Hospital San Francisco, San Francisco, CA

2Department

of Critical Care, UCSF Benioff Children’s Hospital Oakland, Oakland, CA

3Department

of Pediatric Critical Care, UMass Memorial Medical Center, Worcester, MA

4Department

of Family and Community Health, University of Pennsylvania, School of Nursing, Philadelphia, PA 5Division

of Pediatric Critical Care Medicine, Departments of Pediatrics and Public Health Sciences, Penn State Hershey Children’s Hospital, Hershey, PA 6Division

of Pediatric Critical Care, Children’s Hospital of Richmond at VCU, Richmond, VA

7Division

of Pediatric Critical Care Medicine, C.S. Mott Children’s Hospital, Ann Arbor, MI

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Abstract Objectives—To determine if weight extremes impact clinical outcomes in pediatric ARDS (PARDS). Design—Post-hoc analysis of a cohort created by combining 5 multicenter PARDS studies Setting—43 academic pediatric intensive care units worldwide Patients—711 subjects prospectively diagnosed with PARDS

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Intervention—Subjects >2 years were included and categorized by CDC BMI z-score criteria: underweight (