Clinical Endocrinology (2015) 83, 462–467
doi: 10.1111/cen.12761
ORIGINAL ARTICLE
Importance of contralateral aldosterone suppression during adrenal vein sampling in the subtype evaluation of primary aldosteronism Hironobu Umakoshi*, Kanako Tanase-Nakao*, Norio Wada†, Takamasa Ichijo‡, Masakatsu Sone§, Nobuya Inagaki§, Takuyuki Katabami¶, Kohei Kamemura**, Yuichi Matsuda††, Yuichi Fujii‡‡, Tatsuya Kai§§, Tomikazu Fukuoka¶¶, Ryuichi Sakamoto***, Atsushi Ogo***, Tomoko Suzuki†††, Mika Tsuiki*, Akira Shimatsu* and Mitsuhide Naruse* *Department of Endocrinology, Metabolism, and Hypertension, National Hospital Organization Kyoto Medical Center, Kyoto, †Department of Diabetes and Endocrinology, Sapporo City Hospital, Sapporo, ‡Department of Diabetes and Endocrinology, Saiseikai Yokohama City Toubu Hospital, Yokohama, §Department of Diabetes, Endocrinology, and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, ¶Department of Endocrinology and Metabolism, Yokohama City Seibu Hospital, St. Marianna University School of Medicine, Yokohama, **Department of Cardiology, Akashi Medical Center, Akashi, ††Department of Cardiology, Sanda City Hospital, Sanda, ‡‡Department of Cardiology, Hiroshima General Hospital of West Japan Railway Company, Hiroshima, §§Department of Cardiology, Saiseikai Tondabayashi Hospital, Tondabayashi, ¶¶Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, ***Department of Endocrinology and Metabolism, National Hospital Organization Kyushu Medical Center, Fukuoka and †††Department of Public Health, Kitasato University School of Medicine, Tokyo, Japan
Summary Objectives Adrenal vein sampling (AVS) is the standard criterion for the subtype diagnosis in primary aldosteronism (PA). Although lateralized index (LI) ≥4 after cosyntropin stimulation is the commonly recommended cut-off for unilateral aldosterone hypersecretion, many of the referral centres in the world use LI cut-off of
doi: 10.1111/cen.12761
ORIGINAL ARTICLE
Importance of contralateral aldosterone suppression during adrenal vein sampling in the subtype evaluation of primary aldosteronism Hironobu Umakoshi*, Kanako Tanase-Nakao*, Norio Wada†, Takamasa Ichijo‡, Masakatsu Sone§, Nobuya Inagaki§, Takuyuki Katabami¶, Kohei Kamemura**, Yuichi Matsuda††, Yuichi Fujii‡‡, Tatsuya Kai§§, Tomikazu Fukuoka¶¶, Ryuichi Sakamoto***, Atsushi Ogo***, Tomoko Suzuki†††, Mika Tsuiki*, Akira Shimatsu* and Mitsuhide Naruse* *Department of Endocrinology, Metabolism, and Hypertension, National Hospital Organization Kyoto Medical Center, Kyoto, †Department of Diabetes and Endocrinology, Sapporo City Hospital, Sapporo, ‡Department of Diabetes and Endocrinology, Saiseikai Yokohama City Toubu Hospital, Yokohama, §Department of Diabetes, Endocrinology, and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, ¶Department of Endocrinology and Metabolism, Yokohama City Seibu Hospital, St. Marianna University School of Medicine, Yokohama, **Department of Cardiology, Akashi Medical Center, Akashi, ††Department of Cardiology, Sanda City Hospital, Sanda, ‡‡Department of Cardiology, Hiroshima General Hospital of West Japan Railway Company, Hiroshima, §§Department of Cardiology, Saiseikai Tondabayashi Hospital, Tondabayashi, ¶¶Department of Internal Medicine, Matsuyama Red Cross Hospital, Matsuyama, ***Department of Endocrinology and Metabolism, National Hospital Organization Kyushu Medical Center, Fukuoka and †††Department of Public Health, Kitasato University School of Medicine, Tokyo, Japan
Summary Objectives Adrenal vein sampling (AVS) is the standard criterion for the subtype diagnosis in primary aldosteronism (PA). Although lateralized index (LI) ≥4 after cosyntropin stimulation is the commonly recommended cut-off for unilateral aldosterone hypersecretion, many of the referral centres in the world use LI cut-off of
