International Journal of Laboratory Hematology The Official journal of the International Society for Laboratory Hematology
LETTER TO THE EDITOR
INTERNAT IONAL JOURNAL OF LABORATO RY HEMATO LOGY
Letter to the Editor
Inaccuracy in factor VIII measurement due to administration of recombinant activated factor VII in vivo
Introduction Recombinant activated factor VII (rFVIIa) is a bypassing agent used in haemophilia A patients with factor VIII (FVIII) inhibitors. The mechanism of rFVIIa is FVIII independent, as it is thought to improve factor X activation either through a tissue factor-dependent or a platelet surface pathway [1]. We present a case in which in vivo rFVIIa administration led to inaccuracy in FVIII measurement based on the activated partial thromboplastin time (APTT).
Case Report The patient is a 9-year-old Congolese male immigrant. In April 2012, the first sample from this patient was sent to the Finnish Red Cross Blood Service haemostasis laboratory. With the APTT-based one-stage clotting assay,
LETTER TO THE EDITOR
INTERNAT IONAL JOURNAL OF LABORATO RY HEMATO LOGY
Letter to the Editor
Inaccuracy in factor VIII measurement due to administration of recombinant activated factor VII in vivo
Introduction Recombinant activated factor VII (rFVIIa) is a bypassing agent used in haemophilia A patients with factor VIII (FVIII) inhibitors. The mechanism of rFVIIa is FVIII independent, as it is thought to improve factor X activation either through a tissue factor-dependent or a platelet surface pathway [1]. We present a case in which in vivo rFVIIa administration led to inaccuracy in FVIII measurement based on the activated partial thromboplastin time (APTT).
Case Report The patient is a 9-year-old Congolese male immigrant. In April 2012, the first sample from this patient was sent to the Finnish Red Cross Blood Service haemostasis laboratory. With the APTT-based one-stage clotting assay,
