Oncotarget, Vol. 7, No. 13
www.impactjournals.com/oncotarget/
Increased expression of SUMO1P3 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer Yonghao Zhan1,2,3,*, Yuchen Liu1,2,*, Chaoliang Wang4,*, Junhao Lin1,3, Mingwei Chen1, Xiaoying Chen1,3, Chengle Zhuang1,3, Li Liu1,3, Wen Xu1, Qing Zhou1, Xiaojuan Sun1, Qiaoxia Zhang1, Guoping Zhao1,5, Weiren Huang1,2,3 1
ey Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of K Shenzhen University, Shenzhen, China
2
epartment of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer D Centre, Beijing, China
3
Shantou University Medical College, Shantou, China
4
Urology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
5
hanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Centerat Shanghai, S Shanghai, China
*
These authors have contributed equally to this work
Correspondence to: Weiren Huang, e-mail: [email protected] Keywords: SUMO1P3, bladder cancer, tumor growth, tumor metastasis Received: October 01, 2015 Accepted: January 02, 2016 Published: January 19, 2016
ABSTRACT Bladder cancer is one of the most common malignancies worldwide. Long noncoding RNAs (lncRNAs) are a class of non-coding RNAs that play crucial roles in diverse biological processes. The pseudogene-expressed lncRNA is one major type of lncRNA family. Small ubiquitin-like modifier (SUMO) 1 pseudogene 3, (SUMO1P3) is a novel indentified lncRNA that was previously reported to be up-regulated in gastric cancer. However, we know nothing about the biological function and underlying mechanism of SUMO1P3 in tumor. Furthermore, the relationship between SUMO1P3 and bladder cancer is completely unknown. We hypothesized that SUMO1P3 also have roles in bladder cancer. In this study, we found that SUMO1P3 was significantly up-regulated in bladder cancer tissues compared with paired-adjacent nontumorous tissues in a cohort of 55 bladder cancer patients. Moreover, up-regulated SUMO1P3 expression was positively correlated with greater histological grade (P
www.impactjournals.com/oncotarget/
Increased expression of SUMO1P3 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer Yonghao Zhan1,2,3,*, Yuchen Liu1,2,*, Chaoliang Wang4,*, Junhao Lin1,3, Mingwei Chen1, Xiaoying Chen1,3, Chengle Zhuang1,3, Li Liu1,3, Wen Xu1, Qing Zhou1, Xiaojuan Sun1, Qiaoxia Zhang1, Guoping Zhao1,5, Weiren Huang1,2,3 1
ey Laboratory of Medical Reprogramming Technology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of K Shenzhen University, Shenzhen, China
2
epartment of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer D Centre, Beijing, China
3
Shantou University Medical College, Shantou, China
4
Urology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
5
hanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Centerat Shanghai, S Shanghai, China
*
These authors have contributed equally to this work
Correspondence to: Weiren Huang, e-mail: [email protected] Keywords: SUMO1P3, bladder cancer, tumor growth, tumor metastasis Received: October 01, 2015 Accepted: January 02, 2016 Published: January 19, 2016
ABSTRACT Bladder cancer is one of the most common malignancies worldwide. Long noncoding RNAs (lncRNAs) are a class of non-coding RNAs that play crucial roles in diverse biological processes. The pseudogene-expressed lncRNA is one major type of lncRNA family. Small ubiquitin-like modifier (SUMO) 1 pseudogene 3, (SUMO1P3) is a novel indentified lncRNA that was previously reported to be up-regulated in gastric cancer. However, we know nothing about the biological function and underlying mechanism of SUMO1P3 in tumor. Furthermore, the relationship between SUMO1P3 and bladder cancer is completely unknown. We hypothesized that SUMO1P3 also have roles in bladder cancer. In this study, we found that SUMO1P3 was significantly up-regulated in bladder cancer tissues compared with paired-adjacent nontumorous tissues in a cohort of 55 bladder cancer patients. Moreover, up-regulated SUMO1P3 expression was positively correlated with greater histological grade (P
