Tumor Biol. (2015) 36:877–883 DOI 10.1007/s13277-014-2656-8
RESEARCH ARTICLE
Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer Xiao-Lin Wang & Hu-Yang Xie & Chuan-Dong Zhu & Xiao-Fang Zhu & Guang-Xin Cao & Xiao-Hong Chen & Han-Feng Xu
Received: 19 August 2014 / Accepted: 18 September 2014 / Published online: 11 October 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014
Abstract The aims of this study are to analyze the association of microRNA-141 (miR-141) with the clinicopathological parameters of bladder cancer and evaluate the value of miR141 in predicting the prognosis of bladder cancer. In this study, 114 patients with bladder cancer were enrolled in the study, and tissue specimens were obtained from the tumor zone and from adjacent normal area. miR-141 expression was determined using SYRB Green quantitative real-time polymerase chain reaction assay and was further correlated with patients’ clinicopathological parameters and the follow-up data. The results indicated that miR-141 was upregulated in malignant bladder specimens compared with normal ones (P
RESEARCH ARTICLE
Increased miR-141 expression is associated with diagnosis and favorable prognosis of patients with bladder cancer Xiao-Lin Wang & Hu-Yang Xie & Chuan-Dong Zhu & Xiao-Fang Zhu & Guang-Xin Cao & Xiao-Hong Chen & Han-Feng Xu
Received: 19 August 2014 / Accepted: 18 September 2014 / Published online: 11 October 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014
Abstract The aims of this study are to analyze the association of microRNA-141 (miR-141) with the clinicopathological parameters of bladder cancer and evaluate the value of miR141 in predicting the prognosis of bladder cancer. In this study, 114 patients with bladder cancer were enrolled in the study, and tissue specimens were obtained from the tumor zone and from adjacent normal area. miR-141 expression was determined using SYRB Green quantitative real-time polymerase chain reaction assay and was further correlated with patients’ clinicopathological parameters and the follow-up data. The results indicated that miR-141 was upregulated in malignant bladder specimens compared with normal ones (P
