Clinical Infectious Diseases MAJOR ARTICLE HIV/AIDS
Increased Prevalence of Controlled Viremia and Decreased Rates of HIV Drug Resistance Among HIV-Positive People Who Use Illicit Drugs During a Community-wide Treatment-as-Prevention Initiative M.-J. Milloy,1,2 Evan Wood,1,2 Thomas Kerr,1,2 Bob Hogg,1,3 Silvia Guillemi,1 P. Richard Harrigan,1,2 and Julio Montaner1,2 1 British Columbia Centre for Excellence in HIV/AIDS, St. Paul’s Hospital, and 2Division of AIDS, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, and 3Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Background. Although treatment-as prevention (TasP) is a new cornerstone of global human immunodeficiency virus (HIV)– AIDS strategies, its effect among HIV-positive people who use illicit drugs (PWUD) has yet to be evaluated. We sought to describe longitudinal trends in exposure to antiretroviral therapy (ART), plasma HIV-1 RNA viral load (VL) and HIV drug resistance during a community-wide TasP intervention. Methods. We used data from the AIDS Care Cohort to Evaluate Exposure to Survival Services study, a prospective cohort of HIV-positive PWUD linked to HIV clinical monitoring records. We estimated longitudinal changes in the proportion of individuals with VL
Increased Prevalence of Controlled Viremia and Decreased Rates of HIV Drug Resistance Among HIV-Positive People Who Use Illicit Drugs During a Community-wide Treatment-as-Prevention Initiative M.-J. Milloy,1,2 Evan Wood,1,2 Thomas Kerr,1,2 Bob Hogg,1,3 Silvia Guillemi,1 P. Richard Harrigan,1,2 and Julio Montaner1,2 1 British Columbia Centre for Excellence in HIV/AIDS, St. Paul’s Hospital, and 2Division of AIDS, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, and 3Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Background. Although treatment-as prevention (TasP) is a new cornerstone of global human immunodeficiency virus (HIV)– AIDS strategies, its effect among HIV-positive people who use illicit drugs (PWUD) has yet to be evaluated. We sought to describe longitudinal trends in exposure to antiretroviral therapy (ART), plasma HIV-1 RNA viral load (VL) and HIV drug resistance during a community-wide TasP intervention. Methods. We used data from the AIDS Care Cohort to Evaluate Exposure to Survival Services study, a prospective cohort of HIV-positive PWUD linked to HIV clinical monitoring records. We estimated longitudinal changes in the proportion of individuals with VL
