Clinical Science and Molecular Medicine (1 977) 52,43-SO.
Increased renal function in patients with acute left ventricular failure: a possible homeostatic mechanism E. D. BENNETT, N. H. BROOKS, J. K E D D I E , Y. LIS A N D A. WILSON Medical Unit and Department of Radiology, St George's Hospital, London
(Received 15 July 1976;accepted 18 August 1976)
SummarY 1. Creatinine clearance and urine excretion have been measured in fifty-five patients admitted with suspected myocardial infarction. Patients were grouped on the basis of their radiological report on the first day, irrespective of their diagnosis. The first group consisted of twenty-six patients with normal chest X-rays, the second group of twenty-two patients with radiological evidence of upper zone vessel dilatation and the third group of seven patients with radiological evidence of pulmonary oedema, who were significantlyolder. 2. The mean creatinine clearance on the first day in patients with upper zone vessel dilatation was significantly higher than the creatinine clearance in patients with normal radiographs. By the third and fourth days the clearances were similar in both groups. The patients with pulmonary oedemahad low creatinineclearances on all 4 days. 3. Glomerular filtration rate was measured with 51Cr-labelledEDTA on twenty occasions, and the results correlated well with the creatinine clearance values obtained on the same day. 4.The mean urine volumes on day 1 (2245f 286 m1/24 h) and day 2 (2219f232 d/24h) in patients with upper zone vessel dilatation who had not received diuretics, were significantly higher (P
Increased renal function in patients with acute left ventricular failure: a possible homeostatic mechanism E. D. BENNETT, N. H. BROOKS, J. K E D D I E , Y. LIS A N D A. WILSON Medical Unit and Department of Radiology, St George's Hospital, London
(Received 15 July 1976;accepted 18 August 1976)
SummarY 1. Creatinine clearance and urine excretion have been measured in fifty-five patients admitted with suspected myocardial infarction. Patients were grouped on the basis of their radiological report on the first day, irrespective of their diagnosis. The first group consisted of twenty-six patients with normal chest X-rays, the second group of twenty-two patients with radiological evidence of upper zone vessel dilatation and the third group of seven patients with radiological evidence of pulmonary oedema, who were significantlyolder. 2. The mean creatinine clearance on the first day in patients with upper zone vessel dilatation was significantly higher than the creatinine clearance in patients with normal radiographs. By the third and fourth days the clearances were similar in both groups. The patients with pulmonary oedemahad low creatinineclearances on all 4 days. 3. Glomerular filtration rate was measured with 51Cr-labelledEDTA on twenty occasions, and the results correlated well with the creatinine clearance values obtained on the same day. 4.The mean urine volumes on day 1 (2245f 286 m1/24 h) and day 2 (2219f232 d/24h) in patients with upper zone vessel dilatation who had not received diuretics, were significantly higher (P
