Am J Transl Res 2015;7(10):1712-1723 www.ajtr.org /ISSN:1943-8141/AJTR0014076
Original Article Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism Jing Wang, Dong Chen, Xun-Min Cheng, Qi-Gao Zhang, Yong-Ping Peng, Li-Jun Wang, Song-Qing He, Jian-Bin Gong Department of Cardiology, Jinling Hospital, School of Clinical Medicine, Nanjing University, No. 305 East Zhongshan Rd., Nanjing 210002, China Received August 6, 2015; Accepted October 11, 2015; Epub October 15, 2015; Published October 30, 2015 Abstract: Objective: To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. Methods: A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. Results: At week 0, UCP-1 and PPARγ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P
Original Article Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism Jing Wang, Dong Chen, Xun-Min Cheng, Qi-Gao Zhang, Yong-Ping Peng, Li-Jun Wang, Song-Qing He, Jian-Bin Gong Department of Cardiology, Jinling Hospital, School of Clinical Medicine, Nanjing University, No. 305 East Zhongshan Rd., Nanjing 210002, China Received August 6, 2015; Accepted October 11, 2015; Epub October 15, 2015; Published October 30, 2015 Abstract: Objective: To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. Methods: A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. Results: At week 0, UCP-1 and PPARγ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P
