Scandinavian Journal of Clinical and Laboratory Investigation
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs Knut Joachim Berg & Dieter Loew To cite this article: Knut Joachim Berg & Dieter Loew (1977) Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs, Scandinavian Journal of Clinical and Laboratory Investigation, 37:2, 125-131 To link to this article: http://dx.doi.org/10.3109/00365517709156066
Published online: 08 Jul 2009.
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Date: 07 November 2015, At: 05:04
Scatzd. J. clin. Lab. Invest. 37, 125-131, 1977.
Downloaded by [University of California, San Diego] at 05:04 07 November 2015
Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs K N U T JOACHIM BERG & DIETER LOEW Section for Nephrology, Medical Department, University of Trondheim, Norway
Berg, K.J. & Loew, D. Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs. Scand. J. clin. Lab. Invest. 37, 125-131, 1977. The effect of intravenously administered acetylsalicylic acid (ASA) has been investigated in two sets of experiments in conscious dogs. In the first part of the study ASA 70-90 mg/kg was infused for 40 min. Urine flow, free water clearance, renal blood flow and urinary excretion of sodium did not change significantly as compared to placebo treated animals. This is in contrast to the effects of comparable ASA doses in the pentobarbital anaesthetized dog. In the second part of the study the effects of pre-treatment with the same ASA doses or 5 ml 0.6% NaCl (placebo) on some renal effects of furosemide 1 mg/kg (intravenously) were investigated. In the placebo group acute furosemide treatment increased C,, in five out of six dogs and CpaHin all six dogs, these increases being most prominent the first 10 min after drug administration. After pre-treatment with ASA the initial increases in CINand CPAA were almost abolished. CINwas reduced by 23.8% and CpaE,by 30.6% during the first six clearance periods (0-60 min) after diuretic treatment in the ASA group as compared to the placebo group. Although urinary sodium excretion also increased in ASA pre-treated dogs, the effect of furosemide was greater in all dogs in the placebo group (P
ISSN: 0036-5513 (Print) 1502-7686 (Online) Journal homepage: http://www.tandfonline.com/loi/iclb20
Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs Knut Joachim Berg & Dieter Loew To cite this article: Knut Joachim Berg & Dieter Loew (1977) Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs, Scandinavian Journal of Clinical and Laboratory Investigation, 37:2, 125-131 To link to this article: http://dx.doi.org/10.3109/00365517709156066
Published online: 08 Jul 2009.
Submit your article to this journal
Article views: 5
View related articles
Citing articles: 2 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iclb20 Download by: [University of California, San Diego]
Date: 07 November 2015, At: 05:04
Scatzd. J. clin. Lab. Invest. 37, 125-131, 1977.
Downloaded by [University of California, San Diego] at 05:04 07 November 2015
Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs K N U T JOACHIM BERG & DIETER LOEW Section for Nephrology, Medical Department, University of Trondheim, Norway
Berg, K.J. & Loew, D. Inhibition of furosemide-induced natriuresis by acetylsalicylic acid in dogs. Scand. J. clin. Lab. Invest. 37, 125-131, 1977. The effect of intravenously administered acetylsalicylic acid (ASA) has been investigated in two sets of experiments in conscious dogs. In the first part of the study ASA 70-90 mg/kg was infused for 40 min. Urine flow, free water clearance, renal blood flow and urinary excretion of sodium did not change significantly as compared to placebo treated animals. This is in contrast to the effects of comparable ASA doses in the pentobarbital anaesthetized dog. In the second part of the study the effects of pre-treatment with the same ASA doses or 5 ml 0.6% NaCl (placebo) on some renal effects of furosemide 1 mg/kg (intravenously) were investigated. In the placebo group acute furosemide treatment increased C,, in five out of six dogs and CpaHin all six dogs, these increases being most prominent the first 10 min after drug administration. After pre-treatment with ASA the initial increases in CINand CPAA were almost abolished. CINwas reduced by 23.8% and CpaE,by 30.6% during the first six clearance periods (0-60 min) after diuretic treatment in the ASA group as compared to the placebo group. Although urinary sodium excretion also increased in ASA pre-treated dogs, the effect of furosemide was greater in all dogs in the placebo group (P
