Scand J Urol Nephrol 24: 69-73, 1990
INITIAL EFFECT OF ENALAPRIL ON KIDNEY FUNCTION IN PATIENTS WITH MODERATE TO SEVERE CHRONIC NEPHROPATHY Anne-Lise Kamper,’ Henrik S . Thomsen,’ Steen L. Nielsen’ and Svend Strandgaard’ From the Departments of ’Nephrology and ‘Clinical Physiology und Nuclear Medicine, Herlev Hospital, University of Copenhagen. Denmark
Scand J Urol Nephrol Downloaded from informahealthcare.com by Thomas Jefferson University on 12/28/14 For personal use only.
(Submitted for publication February 16. 1989)
Abstract. Angiotensin converting enzyme (ACE) inhibi-
tors has been suggested to halt the progression of chronic renal failure. As the initial step of a controlled trial of this hypothesis, it was investigated whether start of enalapril in patients with severe chronic nephropathy might cause a critical fall in their renal function. Thirty-one patients were studied, 26 on chronic antihypertensive treatment with drugs other than ACE inhibitors and 5 untreated norrnotensive. 5 1Cr-EDTA plasma clearance and renal technetium-99m dimercaptosuccinic acid (99mTc-DMSA) scintigraphy were made before and 24 h after start of enalapril, mean dose 9 mg. Blood pressure fell from median 148/88 to 1l9/78 mmHg @
INITIAL EFFECT OF ENALAPRIL ON KIDNEY FUNCTION IN PATIENTS WITH MODERATE TO SEVERE CHRONIC NEPHROPATHY Anne-Lise Kamper,’ Henrik S . Thomsen,’ Steen L. Nielsen’ and Svend Strandgaard’ From the Departments of ’Nephrology and ‘Clinical Physiology und Nuclear Medicine, Herlev Hospital, University of Copenhagen. Denmark
Scand J Urol Nephrol Downloaded from informahealthcare.com by Thomas Jefferson University on 12/28/14 For personal use only.
(Submitted for publication February 16. 1989)
Abstract. Angiotensin converting enzyme (ACE) inhibi-
tors has been suggested to halt the progression of chronic renal failure. As the initial step of a controlled trial of this hypothesis, it was investigated whether start of enalapril in patients with severe chronic nephropathy might cause a critical fall in their renal function. Thirty-one patients were studied, 26 on chronic antihypertensive treatment with drugs other than ACE inhibitors and 5 untreated norrnotensive. 5 1Cr-EDTA plasma clearance and renal technetium-99m dimercaptosuccinic acid (99mTc-DMSA) scintigraphy were made before and 24 h after start of enalapril, mean dose 9 mg. Blood pressure fell from median 148/88 to 1l9/78 mmHg @
