Sheu et al. Journal of Biomedical Science 2013, 20:82 http://www.jbiomedsci.com/content/20/1/82
RESEARCH
Open Access
Innate immune response after acute myocardial infarction and pharmacomodulatory action of tacrolimus in reducing infarct size and preserving myocardial integrity Jiunn-Jye Sheu1†, Pei-Hsun Sung2†, Steve Leu3, Han-Tan Chai2, Yen-Yi Zhen2, Yi-Ching Chen2, Sarah Chua2, Yung-Lung Chen2, Tzu-Hsien Tsai2, Fan-Yen Lee1, Hsueh-Wen Chang4, Sheung-Fat Ko5* and Hon-Kan Yip2,3*
Abstract Background: This study investigated the association between innate immune reaction and myocardial damage after acute myocardial infarction (AMI) and anti-inflammatory role of tacrolimus in reducing infarct size. Male mini-pigs (n=18) were equally categorized into sham control (SC), untreated AMI (by ligation of left anterior descending coronary artery), and AMI-Tacrolimus (AMI-Tac) (0.5 mg intra-coronary injection 30 minutes post-AMI). Cardiac magnetic resonance imaging (MRI) was performed at post-AMI days 2, 5 and 21 before sacrificing the animals. Results: By post-AMI day 21, left ventricular ejection fraction (LVEF) was lowest in untreated AMI animals, significantly higher in SC than in AMI-Tac group (all p
RESEARCH
Open Access
Innate immune response after acute myocardial infarction and pharmacomodulatory action of tacrolimus in reducing infarct size and preserving myocardial integrity Jiunn-Jye Sheu1†, Pei-Hsun Sung2†, Steve Leu3, Han-Tan Chai2, Yen-Yi Zhen2, Yi-Ching Chen2, Sarah Chua2, Yung-Lung Chen2, Tzu-Hsien Tsai2, Fan-Yen Lee1, Hsueh-Wen Chang4, Sheung-Fat Ko5* and Hon-Kan Yip2,3*
Abstract Background: This study investigated the association between innate immune reaction and myocardial damage after acute myocardial infarction (AMI) and anti-inflammatory role of tacrolimus in reducing infarct size. Male mini-pigs (n=18) were equally categorized into sham control (SC), untreated AMI (by ligation of left anterior descending coronary artery), and AMI-Tacrolimus (AMI-Tac) (0.5 mg intra-coronary injection 30 minutes post-AMI). Cardiac magnetic resonance imaging (MRI) was performed at post-AMI days 2, 5 and 21 before sacrificing the animals. Results: By post-AMI day 21, left ventricular ejection fraction (LVEF) was lowest in untreated AMI animals, significantly higher in SC than in AMI-Tac group (all p
