Respiration Physiology, 89 (1992) 287-298 © 1992 Elsevier Science Publishers B.V. All fights reserved. 0034-5687/92/$05.00
287
RESP 01934
Inspiratory muscle activity during pulmonary edema in anesthetized dogs Arie Oliven a and Steven G. Kelsen b "Department of Medicine 8, 8nai-Zion Medical Center, Haifa, Israel, and bPulmonary Division, Department of Medicine. Case Western Reserve University, School of Medicine, Cleveland, Oil, USA (Accepted 13 April 1992) Abstract. Pulmonary edema is known to induce a rapid and shallow breathing pattern. However, its effects on the level and pattern of distribution of motor activity to the respiratory muscles is unclear. In the present study we evaluated the effect of oleic acid induced pulmonary edema on the electrical activity of the inspiratory muscles (costal and crural diaphragm and parasternal and external intercostal muscles) in the dog, and related it to the transdiaphragmatic pressure and ventilatory parameters over the course of CO2 rebreathing. Pulmor~ary edema, reflected by a 7.1 _. 0.6 wet to dry ratio, decreased lung compliance by 57%, increased pulmonary shunt to 35~, and was associated with a rapid and shallow breathing pattern. When compared at equal levels of Pc
287
RESP 01934
Inspiratory muscle activity during pulmonary edema in anesthetized dogs Arie Oliven a and Steven G. Kelsen b "Department of Medicine 8, 8nai-Zion Medical Center, Haifa, Israel, and bPulmonary Division, Department of Medicine. Case Western Reserve University, School of Medicine, Cleveland, Oil, USA (Accepted 13 April 1992) Abstract. Pulmonary edema is known to induce a rapid and shallow breathing pattern. However, its effects on the level and pattern of distribution of motor activity to the respiratory muscles is unclear. In the present study we evaluated the effect of oleic acid induced pulmonary edema on the electrical activity of the inspiratory muscles (costal and crural diaphragm and parasternal and external intercostal muscles) in the dog, and related it to the transdiaphragmatic pressure and ventilatory parameters over the course of CO2 rebreathing. Pulmor~ary edema, reflected by a 7.1 _. 0.6 wet to dry ratio, decreased lung compliance by 57%, increased pulmonary shunt to 35~, and was associated with a rapid and shallow breathing pattern. When compared at equal levels of Pc
