RESEARCH ARTICLE
Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Zheng Peng1‡, Yifan Sun2‡, Xiaolan Lv3, Hongyu Zhang2, Chunming Liu2*, Shengming Dai1* 1 Department of Clinical Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China, 2 Department of Clinical Laboratory, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou, Guangxi, China, 3 Department of Clinical Laboratory, Liuzhou Maternal and Child Health Care Hospital, Liuzhou, Guangxi, China ‡ ZP and YS are co-first authors on this work. * [email protected] (SD); [email protected] (CL)
Abstract Background
OPEN ACCESS Citation: Peng Z, Sun Y, Lv X, Zhang H, Liu C, Dai S (2016) Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and MetaAnalysis. PLoS ONE 11(2): e0148531. doi:10.1371/ journal.pone.0148531 Editor: Susanne Kaser, Medical University Innsbruck, AUSTRIA Received: November 17, 2015 Accepted: January 20, 2016 Published: February 5, 2016 Copyright: © 2016 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.
The change of serum interleukin-6(IL-6) levels in women with polycystic ovary syndrome (PCOS), as well as the relations between IL-6 levels and body mass index (BMI), insulin resistance(IR) and androgen status of PCOS patients, are not fully understood.
Methods A literature search was performed in October 2015 using PubMed, Embase and the Cochrane Library databases to identify studies. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs).
Results Twenty articles with 25 case-control studies included 1618 women (922 PCOS patients and 696 controls) were included in this study. IL-6 levels in controls were significantly lower than that of PCOS patients (SMD = 0.78, 95%CI = 0.41–1.16, P
Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Zheng Peng1‡, Yifan Sun2‡, Xiaolan Lv3, Hongyu Zhang2, Chunming Liu2*, Shengming Dai1* 1 Department of Clinical Laboratory, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China, 2 Department of Clinical Laboratory, Liuzhou Hospital of Traditional Chinese Medicine, Liuzhou, Guangxi, China, 3 Department of Clinical Laboratory, Liuzhou Maternal and Child Health Care Hospital, Liuzhou, Guangxi, China ‡ ZP and YS are co-first authors on this work. * [email protected] (SD); [email protected] (CL)
Abstract Background
OPEN ACCESS Citation: Peng Z, Sun Y, Lv X, Zhang H, Liu C, Dai S (2016) Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and MetaAnalysis. PLoS ONE 11(2): e0148531. doi:10.1371/ journal.pone.0148531 Editor: Susanne Kaser, Medical University Innsbruck, AUSTRIA Received: November 17, 2015 Accepted: January 20, 2016 Published: February 5, 2016 Copyright: © 2016 Peng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors have no support or funding to report. Competing Interests: The authors have declared that no competing interests exist.
The change of serum interleukin-6(IL-6) levels in women with polycystic ovary syndrome (PCOS), as well as the relations between IL-6 levels and body mass index (BMI), insulin resistance(IR) and androgen status of PCOS patients, are not fully understood.
Methods A literature search was performed in October 2015 using PubMed, Embase and the Cochrane Library databases to identify studies. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs).
Results Twenty articles with 25 case-control studies included 1618 women (922 PCOS patients and 696 controls) were included in this study. IL-6 levels in controls were significantly lower than that of PCOS patients (SMD = 0.78, 95%CI = 0.41–1.16, P
