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Interventricular Dyssynchrony Using Tagging Magnetic Resonance Imaging Predicts Right Ventricular Dysfunction in Adult Congenital Heart Disease Michinobu Nagao, MD,* Yuzo Yamasaki, MD,† Masato Yonezawa, MD,† Yoshio Matsuo, MD,† Takeshi Kamitani, MD,† Kenichiro Yamamura, MD,‡ Ichiro Sakamoto, MD,§ Kohtaro Abe, MD,§ Satoshi Kawanami, MD,† and Hiroshi Honda, MD† Departments of *Molecular Imaging and Diagnosis, †Clinical Radiology, ‡Pediatrics, and §Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan ABSTRACT
Purpose. Right ventricular (RV) failure and ventricular dyssynchrony are strong determinants of prognosis in patients with adult congenital heart disease (ACHD). The aim of this study was to investigate the relationship between interventricular dyssynchrony (IVD) using cine-tagged magnetic resonance imaging (MRI) and RV dysfunction in ACHD patients. Materials and Methods. Sixty-seven patients with ACHD (38 with repaired tetralogy of Fallot; 22 with atrial septal defect; seven with ventricular septal defect) underwent tagging MRI. Time curves of myocardial circumferential strains for RV and left ventricular (LV) free walls were delivered from short-axis cine-tagging images. Contraction delay between RV and LV free walls was computed by cross-correlation analysis of the two strain time curves and was defined as the IVD time (msec). Results. IVD was significantly greater for patients with RV ejection fraction (RVEF)
Interventricular Dyssynchrony Using Tagging Magnetic Resonance Imaging Predicts Right Ventricular Dysfunction in Adult Congenital Heart Disease Michinobu Nagao, MD,* Yuzo Yamasaki, MD,† Masato Yonezawa, MD,† Yoshio Matsuo, MD,† Takeshi Kamitani, MD,† Kenichiro Yamamura, MD,‡ Ichiro Sakamoto, MD,§ Kohtaro Abe, MD,§ Satoshi Kawanami, MD,† and Hiroshi Honda, MD† Departments of *Molecular Imaging and Diagnosis, †Clinical Radiology, ‡Pediatrics, and §Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan ABSTRACT
Purpose. Right ventricular (RV) failure and ventricular dyssynchrony are strong determinants of prognosis in patients with adult congenital heart disease (ACHD). The aim of this study was to investigate the relationship between interventricular dyssynchrony (IVD) using cine-tagged magnetic resonance imaging (MRI) and RV dysfunction in ACHD patients. Materials and Methods. Sixty-seven patients with ACHD (38 with repaired tetralogy of Fallot; 22 with atrial septal defect; seven with ventricular septal defect) underwent tagging MRI. Time curves of myocardial circumferential strains for RV and left ventricular (LV) free walls were delivered from short-axis cine-tagging images. Contraction delay between RV and LV free walls was computed by cross-correlation analysis of the two strain time curves and was defined as the IVD time (msec). Results. IVD was significantly greater for patients with RV ejection fraction (RVEF)
