Accepted Article
Original Article
Bupivacaine in Combination with Fentanyl or Sufentanil in Epidural / Intrathecal † Analgesia for Labor: A Meta-analysis Bo Li, MD., Huixia Wang, MD., Chengjie Gao, MD.*
Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command, Jinan, China Corresponding author: Dr. Chengjie Gao Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command No.25, Shifan Road, Tianqiao District, Jinan 250031, China Tel: +86-531-5166-6661 Fax: +86-531-5166-6661 Email: [email protected] Running head: Fentanyl or Sufentanil with Bupivacaine for Labor Pain Analgesia Conflicts of interest: None.
†
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcph.453]
Received 15 July 2014; Revised 18 December 2014; Accepted 18 December 2014
The Journal of Clinical Pharmacology This article is protected by copyright. All rights reserved DOI: 10.1002/jcph.453
This article is protected by copyright. All rights reserved
Accepted Article
Abstract This study is to compare the effectiveness of combinational use of bupivacaine with fentanyl (BUPI-FEN) and sufentanil (BUPI-SUF) in epidural / intrathecal analgesia for labor. Electronic databases were searched for relevant research papers published between 1985 and 2014. Metaanalyses of mean differences or odds ratios were performed and statistical heterogeneity between
the studies tested by I2 index. Ten studies recruiting a total of 728 women in labor were selected. Concentrations of the anesthetics used as mean±sd were bupivacaine 0.115±0.056%, fentanyl 0.0007±0.001% and sufentanil 0.00017±0.00022%. Duration of analgesia was not significantly
different between BUPI-SUF and BUPI-FEN administered mothers (mean difference [95% CI] of −33.55 [−74.94, 7.83] minutes; P=0.11) under random effects. The onset of analgesia was also not significantly different between both groups (mean difference [95% CI] of −0.61 [−1.38, 0.16] minutes; P=0.12). The number of neonates with Apgar score < 7 was significantly lower in BUPI-FEN group (odd ratio [95% CI] of 0.31 [0.10, 0.95]; P
Original Article
Bupivacaine in Combination with Fentanyl or Sufentanil in Epidural / Intrathecal † Analgesia for Labor: A Meta-analysis Bo Li, MD., Huixia Wang, MD., Chengjie Gao, MD.*
Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command, Jinan, China Corresponding author: Dr. Chengjie Gao Department of Anesthesiology, Jinan General Hospital, PLA Jinan Military Area Command No.25, Shifan Road, Tianqiao District, Jinan 250031, China Tel: +86-531-5166-6661 Fax: +86-531-5166-6661 Email: [email protected] Running head: Fentanyl or Sufentanil with Bupivacaine for Labor Pain Analgesia Conflicts of interest: None.
†
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcph.453]
Received 15 July 2014; Revised 18 December 2014; Accepted 18 December 2014
The Journal of Clinical Pharmacology This article is protected by copyright. All rights reserved DOI: 10.1002/jcph.453
This article is protected by copyright. All rights reserved
Accepted Article
Abstract This study is to compare the effectiveness of combinational use of bupivacaine with fentanyl (BUPI-FEN) and sufentanil (BUPI-SUF) in epidural / intrathecal analgesia for labor. Electronic databases were searched for relevant research papers published between 1985 and 2014. Metaanalyses of mean differences or odds ratios were performed and statistical heterogeneity between
the studies tested by I2 index. Ten studies recruiting a total of 728 women in labor were selected. Concentrations of the anesthetics used as mean±sd were bupivacaine 0.115±0.056%, fentanyl 0.0007±0.001% and sufentanil 0.00017±0.00022%. Duration of analgesia was not significantly
different between BUPI-SUF and BUPI-FEN administered mothers (mean difference [95% CI] of −33.55 [−74.94, 7.83] minutes; P=0.11) under random effects. The onset of analgesia was also not significantly different between both groups (mean difference [95% CI] of −0.61 [−1.38, 0.16] minutes; P=0.12). The number of neonates with Apgar score < 7 was significantly lower in BUPI-FEN group (odd ratio [95% CI] of 0.31 [0.10, 0.95]; P
