Progress in Lipid Research 59 (2015) 54–66
Contents lists available at ScienceDirect
Progress in Lipid Research journal homepage: www.elsevier.com/locate/plipres
Review
Is docosahexaenoic acid synthesis from a-linolenic acid sufficient to supply the adult brain? Anthony F. Domenichiello 1, Alex P. Kitson 1, Richard P. Bazinet ⇑ University of Toronto, Department of Nutritional Sciences, Canada
a r t i c l e
i n f o
Article history: Received 11 August 2014 Accepted 9 April 2015 Available online 25 April 2015 Keywords:: Docosahexaenoic acid Alpha-linolenic Acid DHA ALA Brain Liver Synthesis Uptake Metabolism Requirement
a b s t r a c t Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly from the diet or synthesized in the body from a-linolenic acid (ALA). Debate exists as to whether DHA synthesized from ALA can provide sufficient DHA for the adult brain, as measures of DHA synthesis from ingested ALA are typically
Contents lists available at ScienceDirect
Progress in Lipid Research journal homepage: www.elsevier.com/locate/plipres
Review
Is docosahexaenoic acid synthesis from a-linolenic acid sufficient to supply the adult brain? Anthony F. Domenichiello 1, Alex P. Kitson 1, Richard P. Bazinet ⇑ University of Toronto, Department of Nutritional Sciences, Canada
a r t i c l e
i n f o
Article history: Received 11 August 2014 Accepted 9 April 2015 Available online 25 April 2015 Keywords:: Docosahexaenoic acid Alpha-linolenic Acid DHA ALA Brain Liver Synthesis Uptake Metabolism Requirement
a b s t r a c t Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly from the diet or synthesized in the body from a-linolenic acid (ALA). Debate exists as to whether DHA synthesized from ALA can provide sufficient DHA for the adult brain, as measures of DHA synthesis from ingested ALA are typically
