Molecular Immunology 66 (2015) 274–275
Contents lists available at ScienceDirect
Molecular Immunology journal homepage: www.elsevier.com/locate/molimm
Letter to the Editor Is there association between TLR9 polymorphism and SLE susceptibility?
a r t i c l e
i n f o
Keywords: Toll-like receptor 9 Systemic lupus erythematosus Genetic polymorphism SNP
a b s t r a c t After reading the article “Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes”, we have some doubt. As the differences existed in genetic risk factors, SLE symptoms, and disease severity between the childhood-onset and adult-onset SLE patients, the association analyses in study population including both childhood-onset and adult-onset SLE patients might be inappropriate. Besides, in order to explore whether TLR9 (−1237C/T) polymorphism impact SLE occurrence, we reviewed current studies and conducted a meta-analysis. The results of meta-analysis showed no significant correlation between TLR9 (−1237C/T) and SLE susceptibility in total population (allele model OR = 0.97, 95%CI (0.81–1.14)), or in Caucasians (allele model OR = 1.05, 95%CI (0.72–1.39)) and in Asians (allele model OR = 0.94, 95%CI (0.54–1.35)). Therefore, confirmative evidence reveals that TLR9 (−1237C/T) polymorphism does not correlate with SLE susceptibility. © 2015 Elsevier Ltd. All rights reserved.
Dear Editor, We have read with great interest the article published in Molecular Immunology entitled “Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes” (Devaraju et al., 2015). Interestingly, the study revealed that TLR2 (R753Q) polymorphism was not associated with SLE, while TLR9 (−1237C/T) T allele conferred a significant risk to develop SLE in South Indian Tamils. However, we have some doubt when interpreting the authors’ results. In this article, the mean age of SLE disease onset was 25.5 ± 9.6 years, which implies that the childhood-onset (
Contents lists available at ScienceDirect
Molecular Immunology journal homepage: www.elsevier.com/locate/molimm
Letter to the Editor Is there association between TLR9 polymorphism and SLE susceptibility?
a r t i c l e
i n f o
Keywords: Toll-like receptor 9 Systemic lupus erythematosus Genetic polymorphism SNP
a b s t r a c t After reading the article “Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes”, we have some doubt. As the differences existed in genetic risk factors, SLE symptoms, and disease severity between the childhood-onset and adult-onset SLE patients, the association analyses in study population including both childhood-onset and adult-onset SLE patients might be inappropriate. Besides, in order to explore whether TLR9 (−1237C/T) polymorphism impact SLE occurrence, we reviewed current studies and conducted a meta-analysis. The results of meta-analysis showed no significant correlation between TLR9 (−1237C/T) and SLE susceptibility in total population (allele model OR = 0.97, 95%CI (0.81–1.14)), or in Caucasians (allele model OR = 1.05, 95%CI (0.72–1.39)) and in Asians (allele model OR = 0.94, 95%CI (0.54–1.35)). Therefore, confirmative evidence reveals that TLR9 (−1237C/T) polymorphism does not correlate with SLE susceptibility. © 2015 Elsevier Ltd. All rights reserved.
Dear Editor, We have read with great interest the article published in Molecular Immunology entitled “Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes” (Devaraju et al., 2015). Interestingly, the study revealed that TLR2 (R753Q) polymorphism was not associated with SLE, while TLR9 (−1237C/T) T allele conferred a significant risk to develop SLE in South Indian Tamils. However, we have some doubt when interpreting the authors’ results. In this article, the mean age of SLE disease onset was 25.5 ± 9.6 years, which implies that the childhood-onset (
