JAMA Dermatology
Editor June K. Robinson, MD
Mission Statement JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, dermatologic surgeon, and all those concerned with state-of-the-art care of cutaneous disease. We believe that knowledge derived from well-designed clinical trials and studies
of cost-effectiveness are especially important for improving the practice of dermatology. Studies that increase the understanding of the outcome of treatment or the means by which the burden of dermatologic disease can be measured and reduced to promote the health of patients with skin disease will receive special priority. The journal regularly publishes reports on clinical investigations, editorials, and reviews. It also features reports and discussions on clinicopathologic correlations; clinical disorders of unique didactic value; pharmacologic, medical and surgical therapeutics; and ethical, moral, socioeconomic, and political issues.
Associate Editor Jeffrey P. Callen, MD Louisville, Kentucky Editorial Assistants Julia Getts Chicago, Illinois Keith Howard Chicago, Illinois Editorial Office JAMA Dermatology 132 E Delaware Pl, #5806, Chicago, IL 60611 [email protected] SECTION EDITORS CME Editor Andrew D. Samel, MD, Attleboro, Massachusetts JAMA Dermatology Clinical Evidence Synopsis April W. Armstrong, MD, MPH, Los Angeles, California Assistant Section Editors Daihung Do, MD, Boston, Massachusetts Victoria R. Sharon, MD, DTMH, Sacramento, California JAMA Dermatology Patient Page Misha Rosenbach, MD, Philadelphia, Pennsylvania JAMA Dermatology Clinicopathological Challenge Section Editor Molly A. Hinshaw, MD, Madison, Wisconsin Assistant Section Editors Soon Bahrami, MD, Louisville, Kentucky Nicole Fett, MD, MSCE, Portland, Oregon John R. Griffin, MD, Dallas, Texas
PUBLICATION STAFF Executive Editor Phil B. Fontanarosa, MD, MBA Executive Managing Editor Annette Flanagin Managing Editor Brenda Gregoline Deputy Managing Editor Lauren Fischer Senior Manuscript Editors Karen L. Boyd, John McFadden Manuscript Editors Gabriel Dietz, Rochelle C. Lodder, Sam Wilder Freelance Manuscript Editing Manager Connie L. Manno Freelance Manuscript Editing Coordinators Sara M. Billings, Timothy Gray, Paul Ruich Freelance Copy Editors and Copyreaders Catherine A. Alden, Stephanie Lang Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Brandy Y. Patton, Donna J. Thordsen Editorial Assistant Wanda Hill Editorial Operations & Systems Directors Larry Bryant, Monica Mungle, Elaine Williams
Arni K. Kristjansson, MD, West Hartford, Connecticut Lori D. Prok, MD, Boulder, Colorado Assistant Editors Robin L. Travers, MD, Boston, Massachusetts Eleni Linos, MD, DrPH, San Francisco, California Web Editor Ashish C. Bhatia, MD, Naperville, Illinois EDITORIAL BOARD April W. Armstrong, MD, MPH, Los Angeles, California Ashish C. Bhatia, MD, Naperville, Illinois Jeremy S. Bordeaux, MD, MPH, Cleveland, Ohio Anna L. Bruckner, MD, Aurora, Colorado Edward W. Cowen, MD, MHSc, Bethesda, Maryland Craig A. Elmets, MD, Birmingham, Alabama Johann E. Gudjonsson, MD, PhD, Ann Arbor, Michigan Claudia Hernandez, MD, Chicago, Illinois Kenneth A. Katz, MD, MSc, MSCE, San Francisco, California Robert Kirsner, MD, PhD, Miami, Florida Eleni Linos, MD, DrPH, San Francisco, California Managers and Staff Fanny L. Brown, Lenette Gardner-Gullens, Erin Kato, Peter K. Kim, Rachell Lozano, Michaela Mark, Caroline Sietmann, Elizabeth Zak Scientific Online Resources Deputy Editor and Director Michael Berkwits, MD Director, Development and Design Michelle Kurzynski Manager, Digital Media Prodution Eric Butkus Staff Carrie Butt, Mary Lynn Ferkaluk, Daniel Morrow, Reuben Rios Editorial Graphics Deputy Editor and Director Ronna Henry, MD Staff Karen Bucher, Andy Rekito, Emily Ling, David Song Clinical Review & Education Deputy Editor Edward H. Livingston, MD CME Editor Thomas B. Cole, MD, MPH Budgets and Administration Director Marla A. Hall Staff Deanna Willis, Yolanda Davis Editorial Counsel Joseph P. Thornton, JD Media Relations Manager Deanna Bellandi Staff Jim Michalski
Ashfaq A. Marghoob, MD, New York, New York Amy J. McMichael, MD, Winston-Salem, North Carolina Cindy England Owen, MD, Louisville, Kentucky David M. Ozog, MD, Detroit, Michigan Misha Rosenbach, MD, Philadelphia, Pennsylvania Julie V. Schaffer, MD, Hackensack, New Jersey
Editor in Chief, The JAMA Network Howard Bauchner, MD
Marcia Ramos-e-Silva, MD, PhD, Rio de Janeiro, Brazil Luis Requena, MD, Madrid, Spain Jean E. Revuz, MD, Créteil, France Hiroshi Shimizu, MD, Sapporo, Japan Jacek C. Szepietowski, MD, PhD, Wrocław, Poland T. Thirumoorthy, MD, Singapore Antonella Tosti, MD, Bologna, Italy Hans Christian Wulf, MD, Copenhagen, Denmark Wen-Yuan Zhu, MD, Nanjing, China
INTERNATIONAL ADVISORY COMMITTEE
FORMER EDITORS
Alvaro E. Acosta, MD, Bogotá, Colombia Sultan Al-Khenaizan, MD, Riyadh, Saudi Arabia Reuven Bergman, MD, Haifa, Israel Luca Borradori, MD, Bern, Switzerland Jan Nico Bouwes Bavinck, MD, Leiden, the Netherlands Lorenzo Cerroni, MD, Graz, Austria Sunil Dogra, MD, DNB, FRCP, Chandigarh, India Yahya Dowlati, MD, PhD, Tehran, Iran Reinhard Dummer, MD, Zurich, Switzerland Andreas D. Katsambas, MD, Athens, Greece Alexander Kreuter, MD, Oberhausen, Germany Margarita M. Larralde, MD, Buenos Aires, Argentina Dédée F. Murrell, MA, BMBCh, FAAD, MD, FACD, Sydney, Australia Graham Ogg, FRCP, DPhil, BMBCh, Oxford, England Fezal Ozdemir, MD, Izmir, Turkey
Henry G. Piffard, MD 1882-1885 Prince A. Morrow, MD 1882-1891 John A. Fordyce, MD 1891-1896 James C. Johnston, MD 1896-1902 George K. Swinburne, MD 1896-1902 Bolesław Lapowski, MD 1896-1909 A. D. Mewborn, MD 1903-1908 George M. Mackee, MD 1909-1919 William Allen Pusey, MD 1920-1936 Howard Fox, MD 1937-1946 Paul O’Leary, MD 1947-1955 Herbert Rattner, MD 1955-1961 Harvey Blank, MD 1962-1963 Walter C. Lobitz, MD 1964-1968 Robert R. Kierland, MD 1969-1973 John H. Epstein, MD 1974-1978 Frederick A. Malkinson, MD 1979-1983 Kenneth A. Arndt, MD 1984-2003
PERIODICAL PUBLISHING STAFF
Associate Publisher/Senior Product Development Geoffrey Flick Managers Rick Bell, Fergus Clare, Lindsay Dawson, Will English IV, Ellen Gibson, Mustafa Ishaq, Craig McCaffrey, Michael McGraw, Daniel Pickhardt, Romando Rossini, Stacy Tucker Business Analyst Sirisha Alluri Staff Millette Jackson-Bates Business Operations Directors Karl Elvin, Nancy Essex, Jaye Mize, Sean O’Donnell, Sue Sherrill Managers David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Tiffany Jones, Colleen Kelly, Chris Meyer, Annemarie Neff, J.D. Neff, Sean Ohlson, Phil O’Leary, Bill Pedone, Susan Price, Binita Shah, Denise Steinhauser, Erin Van Dusen, Joe Wixted Advertising and Production Services Ahmed Avendano, Kim Boler, Rhonda Bailey Brown, Fin Carter, Daniel DeGroot, Shawn Hansen, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara Circulation Services Julie Burton, Noemi Rivera, Mary Sieck, Sarah Subramanian, Geneine Van Someren Composition and New Media Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Mary Ann Kuranda, Joshua Lampinen, Nathan Mitre, Patricia E. Panek, La’son Diggs Sledge Graphics Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski Proofreading Carol Joy Farrell, Daniel James, Judith A. Literskis, Teresa H. Omiotek, Michael Ryder
Senior Vice President and Publisher, Periodical Publications Thomas J. Easley Vice President, Publishing Business Operations Brian Shields Vice President, Publishing Production Operations Karen Adams-Taylor Staff Monica Smith Advertising Print & Online Sales & Marketing Director Jeffery J. Bonistalli Manager Kathy Russell Staff Mirna Monal Sales Representatives Stacey McHugh, Tim Melroy Director, Marketing Mark Thornbury Staff Tricia Castellano Classified Advertising Manager Thalia Moss Staff Susan J. Henning, Tiffani Stevenson Reprint Communications Manager Susan Lovenberg Circulation Print & Online Sales & Marketing Director, Worldwide Sales Vida Damijonaitis Managers Saskia Bolore, Gretchen Linder, Brian McCartney Sales Representatives Christine Hearne, Rebecca Lisek Staff David Baum, Natasha Nekola, Ron Thomas Marketing and Product Development Directors Paul Gee, Elizabeth Solaro
The JAMA Network is a consortium of peer-reviewed print and online medical publications that includes JAMA®, JAMA Dermatology, and other specialty journals. JAMA Dermatology does not hold itself responsible for statements made by any contributor. All articles published, including opinion articles, represent the views of the authors and do not reflect the policy of the Journal, the American Medical Association, or the institution with which the author is affiliated, unless otherwise indicated. © 2017 American Medical Association. All rights reserved. Reproduction without permission is prohibited.
AMA EXECUTIVES Executive Vice President, Chief Executive Officer James L. Madara, MD Chief Operating Officer Bernard L. Hengesbaugh
JAMA Dermatology August 2017 Volume 153, Number 8
jamadermatology.com
Copyright 2017 American Medical Association. All rights reserved.
Downloaded From: http://archderm.jamanetwork.com/ on 08/23/2017
737
Editor June K. Robinson, MD
Mission Statement JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, dermatologic surgeon, and all those concerned with state-of-the-art care of cutaneous disease. We believe that knowledge derived from well-designed clinical trials and studies
of cost-effectiveness are especially important for improving the practice of dermatology. Studies that increase the understanding of the outcome of treatment or the means by which the burden of dermatologic disease can be measured and reduced to promote the health of patients with skin disease will receive special priority. The journal regularly publishes reports on clinical investigations, editorials, and reviews. It also features reports and discussions on clinicopathologic correlations; clinical disorders of unique didactic value; pharmacologic, medical and surgical therapeutics; and ethical, moral, socioeconomic, and political issues.
Associate Editor Jeffrey P. Callen, MD Louisville, Kentucky Editorial Assistants Julia Getts Chicago, Illinois Keith Howard Chicago, Illinois Editorial Office JAMA Dermatology 132 E Delaware Pl, #5806, Chicago, IL 60611 [email protected] SECTION EDITORS CME Editor Andrew D. Samel, MD, Attleboro, Massachusetts JAMA Dermatology Clinical Evidence Synopsis April W. Armstrong, MD, MPH, Los Angeles, California Assistant Section Editors Daihung Do, MD, Boston, Massachusetts Victoria R. Sharon, MD, DTMH, Sacramento, California JAMA Dermatology Patient Page Misha Rosenbach, MD, Philadelphia, Pennsylvania JAMA Dermatology Clinicopathological Challenge Section Editor Molly A. Hinshaw, MD, Madison, Wisconsin Assistant Section Editors Soon Bahrami, MD, Louisville, Kentucky Nicole Fett, MD, MSCE, Portland, Oregon John R. Griffin, MD, Dallas, Texas
PUBLICATION STAFF Executive Editor Phil B. Fontanarosa, MD, MBA Executive Managing Editor Annette Flanagin Managing Editor Brenda Gregoline Deputy Managing Editor Lauren Fischer Senior Manuscript Editors Karen L. Boyd, John McFadden Manuscript Editors Gabriel Dietz, Rochelle C. Lodder, Sam Wilder Freelance Manuscript Editing Manager Connie L. Manno Freelance Manuscript Editing Coordinators Sara M. Billings, Timothy Gray, Paul Ruich Freelance Copy Editors and Copyreaders Catherine A. Alden, Stephanie Lang Beckmeyer, Jane Calayag, Jan Clavey, Mary Coerver-Connolly, Paula Glitman, Laura King, Brandy Y. Patton, Donna J. Thordsen Editorial Assistant Wanda Hill Editorial Operations & Systems Directors Larry Bryant, Monica Mungle, Elaine Williams
Arni K. Kristjansson, MD, West Hartford, Connecticut Lori D. Prok, MD, Boulder, Colorado Assistant Editors Robin L. Travers, MD, Boston, Massachusetts Eleni Linos, MD, DrPH, San Francisco, California Web Editor Ashish C. Bhatia, MD, Naperville, Illinois EDITORIAL BOARD April W. Armstrong, MD, MPH, Los Angeles, California Ashish C. Bhatia, MD, Naperville, Illinois Jeremy S. Bordeaux, MD, MPH, Cleveland, Ohio Anna L. Bruckner, MD, Aurora, Colorado Edward W. Cowen, MD, MHSc, Bethesda, Maryland Craig A. Elmets, MD, Birmingham, Alabama Johann E. Gudjonsson, MD, PhD, Ann Arbor, Michigan Claudia Hernandez, MD, Chicago, Illinois Kenneth A. Katz, MD, MSc, MSCE, San Francisco, California Robert Kirsner, MD, PhD, Miami, Florida Eleni Linos, MD, DrPH, San Francisco, California Managers and Staff Fanny L. Brown, Lenette Gardner-Gullens, Erin Kato, Peter K. Kim, Rachell Lozano, Michaela Mark, Caroline Sietmann, Elizabeth Zak Scientific Online Resources Deputy Editor and Director Michael Berkwits, MD Director, Development and Design Michelle Kurzynski Manager, Digital Media Prodution Eric Butkus Staff Carrie Butt, Mary Lynn Ferkaluk, Daniel Morrow, Reuben Rios Editorial Graphics Deputy Editor and Director Ronna Henry, MD Staff Karen Bucher, Andy Rekito, Emily Ling, David Song Clinical Review & Education Deputy Editor Edward H. Livingston, MD CME Editor Thomas B. Cole, MD, MPH Budgets and Administration Director Marla A. Hall Staff Deanna Willis, Yolanda Davis Editorial Counsel Joseph P. Thornton, JD Media Relations Manager Deanna Bellandi Staff Jim Michalski
Ashfaq A. Marghoob, MD, New York, New York Amy J. McMichael, MD, Winston-Salem, North Carolina Cindy England Owen, MD, Louisville, Kentucky David M. Ozog, MD, Detroit, Michigan Misha Rosenbach, MD, Philadelphia, Pennsylvania Julie V. Schaffer, MD, Hackensack, New Jersey
Editor in Chief, The JAMA Network Howard Bauchner, MD
Marcia Ramos-e-Silva, MD, PhD, Rio de Janeiro, Brazil Luis Requena, MD, Madrid, Spain Jean E. Revuz, MD, Créteil, France Hiroshi Shimizu, MD, Sapporo, Japan Jacek C. Szepietowski, MD, PhD, Wrocław, Poland T. Thirumoorthy, MD, Singapore Antonella Tosti, MD, Bologna, Italy Hans Christian Wulf, MD, Copenhagen, Denmark Wen-Yuan Zhu, MD, Nanjing, China
INTERNATIONAL ADVISORY COMMITTEE
FORMER EDITORS
Alvaro E. Acosta, MD, Bogotá, Colombia Sultan Al-Khenaizan, MD, Riyadh, Saudi Arabia Reuven Bergman, MD, Haifa, Israel Luca Borradori, MD, Bern, Switzerland Jan Nico Bouwes Bavinck, MD, Leiden, the Netherlands Lorenzo Cerroni, MD, Graz, Austria Sunil Dogra, MD, DNB, FRCP, Chandigarh, India Yahya Dowlati, MD, PhD, Tehran, Iran Reinhard Dummer, MD, Zurich, Switzerland Andreas D. Katsambas, MD, Athens, Greece Alexander Kreuter, MD, Oberhausen, Germany Margarita M. Larralde, MD, Buenos Aires, Argentina Dédée F. Murrell, MA, BMBCh, FAAD, MD, FACD, Sydney, Australia Graham Ogg, FRCP, DPhil, BMBCh, Oxford, England Fezal Ozdemir, MD, Izmir, Turkey
Henry G. Piffard, MD 1882-1885 Prince A. Morrow, MD 1882-1891 John A. Fordyce, MD 1891-1896 James C. Johnston, MD 1896-1902 George K. Swinburne, MD 1896-1902 Bolesław Lapowski, MD 1896-1909 A. D. Mewborn, MD 1903-1908 George M. Mackee, MD 1909-1919 William Allen Pusey, MD 1920-1936 Howard Fox, MD 1937-1946 Paul O’Leary, MD 1947-1955 Herbert Rattner, MD 1955-1961 Harvey Blank, MD 1962-1963 Walter C. Lobitz, MD 1964-1968 Robert R. Kierland, MD 1969-1973 John H. Epstein, MD 1974-1978 Frederick A. Malkinson, MD 1979-1983 Kenneth A. Arndt, MD 1984-2003
PERIODICAL PUBLISHING STAFF
Associate Publisher/Senior Product Development Geoffrey Flick Managers Rick Bell, Fergus Clare, Lindsay Dawson, Will English IV, Ellen Gibson, Mustafa Ishaq, Craig McCaffrey, Michael McGraw, Daniel Pickhardt, Romando Rossini, Stacy Tucker Business Analyst Sirisha Alluri Staff Millette Jackson-Bates Business Operations Directors Karl Elvin, Nancy Essex, Jaye Mize, Sean O’Donnell, Sue Sherrill Managers David Antos, Chris Borden, Debbie Camp, Lydia Cruz, Scott Curl, Diane Darnell, Jordynn Farrar, Tiffany Jones, Colleen Kelly, Chris Meyer, Annemarie Neff, J.D. Neff, Sean Ohlson, Phil O’Leary, Bill Pedone, Susan Price, Binita Shah, Denise Steinhauser, Erin Van Dusen, Joe Wixted Advertising and Production Services Ahmed Avendano, Kim Boler, Rhonda Bailey Brown, Fin Carter, Daniel DeGroot, Shawn Hansen, Euwanaha Joiner-Smith, Joshua Lane, Cindy Rendlen, Ellen Yoshihara Circulation Services Julie Burton, Noemi Rivera, Mary Sieck, Sarah Subramanian, Geneine Van Someren Composition and New Media Gail Barrett, Regina Brownlee, Amanda Camino, Brenda Chandler-Grayer, Emily Dunn, Amy Evers, Maleeka Holden, Teri Hutchison, Mary Ann Kuranda, Joshua Lampinen, Nathan Mitre, Patricia E. Panek, La’son Diggs Sledge Graphics Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski Proofreading Carol Joy Farrell, Daniel James, Judith A. Literskis, Teresa H. Omiotek, Michael Ryder
Senior Vice President and Publisher, Periodical Publications Thomas J. Easley Vice President, Publishing Business Operations Brian Shields Vice President, Publishing Production Operations Karen Adams-Taylor Staff Monica Smith Advertising Print & Online Sales & Marketing Director Jeffery J. Bonistalli Manager Kathy Russell Staff Mirna Monal Sales Representatives Stacey McHugh, Tim Melroy Director, Marketing Mark Thornbury Staff Tricia Castellano Classified Advertising Manager Thalia Moss Staff Susan J. Henning, Tiffani Stevenson Reprint Communications Manager Susan Lovenberg Circulation Print & Online Sales & Marketing Director, Worldwide Sales Vida Damijonaitis Managers Saskia Bolore, Gretchen Linder, Brian McCartney Sales Representatives Christine Hearne, Rebecca Lisek Staff David Baum, Natasha Nekola, Ron Thomas Marketing and Product Development Directors Paul Gee, Elizabeth Solaro
The JAMA Network is a consortium of peer-reviewed print and online medical publications that includes JAMA®, JAMA Dermatology, and other specialty journals. JAMA Dermatology does not hold itself responsible for statements made by any contributor. All articles published, including opinion articles, represent the views of the authors and do not reflect the policy of the Journal, the American Medical Association, or the institution with which the author is affiliated, unless otherwise indicated. © 2017 American Medical Association. All rights reserved. Reproduction without permission is prohibited.
AMA EXECUTIVES Executive Vice President, Chief Executive Officer James L. Madara, MD Chief Operating Officer Bernard L. Hengesbaugh
JAMA Dermatology August 2017 Volume 153, Number 8
jamadermatology.com
Copyright 2017 American Medical Association. All rights reserved.
Downloaded From: http://archderm.jamanetwork.com/ on 08/23/2017
737
