TRANSACTIONS OF THE AMERICAN CLINICAL AND CLIMATOLOGICAL ASSOCIATION, VOL. 128, 2017

Jeremiah Metzger Lectures 1964 John Eager Howard, M.D. Urinary Stone. 1965 Grant W. Liddle, M.D. Analyse Circadian Rhythms of Adrenal Secretions. 1966 John P. Merrill, M.D. What Can We Do for the Patient with Renal Failure? 1967 Steward Wolf, M.D. Neural Mechanisms in Sudden Cardiac Death 1968 Robert W. Wilkins, M.D. Clinical and Climatological Observations of Hypertension. 1969 James B. Wyngaarden, M.D. The Pathophysiology of Hyperuricemia in Gout. 1970 A. McGehee Harvey, M.D. Myasthenia Gravis—The First 100 Years of Perspective. 1971 Marvin D. Siperstein, M.D., Ph.D. The Relationship of Cholesterol Biosynthesis to Cancer. 1972 George F. Cahill, Jr., M.D. Ketosis. 1973 Richard B. Hornick, M.D. Salmonella Infections—Newer Perspectives of an Old Infection. 1974 Jacques Genest, M.D. The Renin-Angiotensin System. 1975 Victor A. McKusick, M.D. New Genetic Insight into Old Diseases. 1976 Robert M. Bird, M.D. Information Transfer in the Service of Medicine. 1977 Robert Austrian, M.D. of Gold and Pneumococci. 1978 Carl W. Gottschalk, M.D. The Nephrons in Bright’s Disease: Their Structure and Function. 1979 Sheldon M. Wolff, M.D. The Pathogenesis of Fever in Human Subjects. 1980 Charles C. J. Carpenter, M.D. Myths, Mandarins and Molecules: The Cautionary Tale of Cholera. 1981 Leighton E. Cluff, M.D. The Climate of Patient Care and Medical Education. 1982 Daniel D. Federman, M.D. The Determinants of Human Sexuality. 1983 Purnell W. Choppin, M.D. Membrane Proteins and Virus Virulence. 1984 Jack M. Gwaltney, Jr., M.D. Climatology and the Common Cold. 1985 Louis Tobian, M.D. High Potassium Diets Strongly Protect Against Stroke Deaths and Renal Disease: A Possible Legacy from Prehistoric Man. 1986 Richard S. Ross, M.D. Thrombolysis and Dilatation in Coronary Occlusion. 1987 William N. Kelley, M.D. and Thomas D. Palella, M.D. Current Status of Human Gene Therapy. 1988 John A. Oates, M.D. Participation of Eicosanoids in the Syndromes of Myocardial Ischemia. 1989 David G. Nathan, M.D. The Regulation of Hematopoiesis by Growth Factors. 1990 Michel Chrétien, O.C., M.D. From POMC to Functional Diversity of Neural Peptides: The Key Importance of Convertases. 1991 Gerald L. Mandell, M.D. Microbial Defenses Against Killing by Phagocytes. 273

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1992 Jeremiah A. Barondess, M.D. The Future of Generalism. 1993 John D. Stobo, M.D. Academic Health Centers: Change Agents for Health Care Reform. 1994 J. Claude Bennett, M.D. Academic Medicine: Building on the Strengths of the Past as We Approach a Cloudy Future. 1995 Stuart Bondurant, M.D. On the Climate of the City. 1996 Edward W. Hook, M.D. Humanities in Medicine: Treatment of a Deficiency Disorder. 1997 R. Gordon Douglas, Jr., M.D. Vaccine Prophylaxis Today: It’s Science, Application and Politics. 1998 James R. Gavin, III. Academe Confronts a Future of Growing Diversity: Will We Lead or Will We Follow? 1999 John Mendelsohn, M.D. Targeted Cancer Therapy. 2000 Ralph L. Nachman, M.D. Hypercoagulable States: Challenges and Opportunities. 2001 Jared J. Grantham, M.D. Polycystic Kidney Disease: Old Disease in a New Context. 2002 R. Wayne Alexander, M.D., Ph.D. Pathogenesis of Atherosclerosis: Redox As a Unifying Mechanism. 2003 Merle A. Sande, M.D., MACP The Terrible Impact of AIDS on Africa— The Case for Prevention & Treatment Now. 2004 C. Richard Conti, M.D. The Evolution of Management of Acute Coronary Syndromes. 2005 John G. Bartlett, M.D. Avian Influenza. 2006 James A. Fagan, M.D. Intelligent Design of Cancer Therapy: Trials and Tribulations. 2007 Stephen B. Greenberg. Osler-Web-Rendezvous: Impact of the Information Explosion on Medical Education. 2008 Katherine A. High, M.D. Gene Therapy for Inherited Disorders: From Christmas Disease to Leber’s Amaurosis 2009 Eric G. Neilson, M.D. The Origin of Fibroblasts and the Terminality of Epithelial Differentiation 2010 Antonio M. Gotto, M.D. Cholesterol, Inflammation and Cardiovascular Disease: Is It All LDL? 2011 Martin JL. Blaser, M.D. Global Warming Redux: The Disappearing Microbiota and Epidemic Obesity 2012 Nancy J. Brown, M.D. Developing Physician-Scientists: A perspective 2013 Christopher Plowe, M.D. New Additions to the Toolbox for Glosbal Malaria Eradication. 2014 Raymond N. Dubois, M.D., Ph.D. Inflammation, Immune Modulators and Chronic Disease. 2015 Anne A. Gershon, M.D., and Michael D. Gershon, M.D. Varicella Zoster Virus: From Outside to Inside. 2016 edward j. benz, jr., m.d. Cancer in the Twenty-First Century: An Inside View From an Outsider. 274

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JEREMIAH METZGER LECTURES.

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