J Mol Neurosci (2014) 54:291–292 DOI 10.1007/s12031-014-0444-y
Journal of Molecular Neuroscience: Impacting Our Brains Illana Gozes
Published online: 21 October 2014 # Springer Science+Business Media New York 2014
The Journal of Molecular Neuroscience has seen a great expansion of published articles over the last three years and the question is, which are the highly cited articles? In other words, where does molecular neuroscience head these days? The most cited article of all times is by Mattson and colleagues entitled, “Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth” (published 2000 and cited ∼370 times). Lagging behind it is the article by Assaf and colleagues entitled, “Diffusion tensor imaging (DTI)based white matter mapping in brain research: a review” (published 2008 and cited ∼270). In the third place is a paper by Morris and Price entitled: “Pathologic correlates of nondemented aging, mild cognitive impairment, and earlystage Alzheimer’s disease” (published 2001 and cited ∼240 times). These papers make their mark on tissue culture experiments, understanding of brain function by imaging and understanding disease mechanisms. While there are many more highly cited articles including several excellent articles by the Mattson group as well as the discovery of protection against oxidative damage to CNS by alpha-phenyl-tert-butyl-nitrone (PBN) and other spin-trapping agents—a novel series of nonlipid free-radical scavengers, Carney and Floyd, 1991 (cited ∼150 times), a first Cloning, pharmacological characterization, and anatomical distribution of a rat cDNAencoding for a Galanin receptor, Burgevin et al., 1995 and Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier, by Kastin and colleagues, as well as Intracellular mechanisms of amyloid accumulation and
I. Gozes (*) The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Department of Humana Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel e-mail: [email protected]
pathogenesis in Alzheimer’s disease, by Glabe and colleagues, each cited ∼145 times and published 2001–2002. Moving to 2013, highly impacting articles include 1) Expression Patterns of miR-124, miR-134, miR-132, and miR21 in an Immature Rat Model and Children with Mesial Temporal Lobe Epilepsy, by Peng, Jing; Omran, Ahmed; Ashhab, Muhammad Usman; et al., 2) Aberrant Expression of Long Noncoding RNAs in Autistic Brain, by Ziats, Mark N.; Rennert, Owen M., and 3) Protective Effects of 7,8Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress, by Gupta, Vivek K.; You, Yuyi; Li, Jonathan C.; et al., each cited 12 times. 2014, recently published and already cited, are listed below (Alani et al. 2014; Campanari et al. 2014; Carrion et al. 2014; Chang et al. 2014; Ganko and Calka 2014; Gozes et al. 2014; Joachim et al. 2014; Kalani et al. 2014; Kaplan et al. 2014; Kisos et al. 2014; Li et al. 2014a, b; Liu et al. 2014; Lushchekina et al. 2014; Murthy et al. 2014; Nicolas et al. 2014; Ohno et al. 2014; Ortuno-Sahagun et al. 2014; Reuss 2014; Sokolowska et al. 2014; Wang et al. 2014; Wu et al. 2014; Xu et al. 2014; Youssef et al. 2014; Zhang et al. 2014). My own most cited publication in the Journal of Molecular Neuroscience is entitled as follows: “Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer’s disease at early pathological stage”, from 2007, cited 86 times. In addition, many of publications co-authored by Douglas E. Brenneman (USA) and me, are highly cited. Additional popular citations are of complex linkage analyses, associated with disease mechanisms and pathologies in humans, with many contributions from the J. Oliveira group in Brazil; stem cells and neurodegenerative mechanisms from the D. Offen group in Israel; cytoskeleton and glial cells from the C. Richter-Landsberg group in Germany; and versatile papers in molecular neuroscience by the Soreq group in Israel. Furthermore, in the neuropeptide field, the Shioda group from
292
Japan, the May, Eiden and Loh groups from the USA, and the Reglodi group from Hungary are avid, cited contributors. Obviously, I am missing many, but need to leave something to future editorial notes. The current issue pays tribute to neuropeptides, with the some of the above listed authors. Importantly, this issue pays tribute to Professor Uriel Z. Littauer (Gozes et al. 2002), a mentor to many of us, who passed away recently. Professor Uri Littauer was among the founding pillars of Molecular Neuroscience. We will remember him in follow up issues in 2015 and beyond. With this, I would like to take this opportunity to thank all authors and reviewers for their vital contribution, most importantly, our Editorial Board Members the previous Editors, including, the founder Paul Marangos, Colin J. Barnstable whose publications are highly cited as well as my previous co-editor Mark Mattson (cited above) and the Publishers, Humana Press and Springer. The interest obviously results in new basic and disease mechanisms looking at all aspects of molecular neuroscience. I am looking forward to an exciting 2015!
References Alani B, Salehi R, Sadeghi P, Zare M, Khodagholi F, Arefian E, Hakemi MG, Digaleh H (2014) Silencing of Hsp90 chaperone expression protects against 6-hydroxydopamine toxicity in PC12 cells. J Mol Neurosci 52:392–402 Campanari ML, Garcia-Ayllon MS, Blazquez-Llorca L, Luk WKW, Tsim K, Saez-Valero J (2014) Acetylcholinesterase protein level is preserved in the Alzheimer’s brain. J Mol Neurosci 53:446–453 Carrion M, Juarranz Y, Seoane IV, Martinez C, Gonzalez-Alvaro I, Pablos JL, Gutierrez-Canas I, Gomariz RP (2014) VIP modulates IL-22R1 expression and prevents the contribution of rheumatoid synovial fibroblasts to IL-22-mediated joint destruction. J Mol Neurosci 52: 10–17 Chang P, Dong WW, Zhang MY, Wang ZF, Wang YQ, Wang T, Gao Y, Meng HH, Luo B, Luo CL, Chen XP, Tao LY (2014) Antinecroptosis chemical necrostatin-1 Can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci 52:242–249 Ganko M, Calka J (2014) Localization and chemical coding of the dorsal motor vagal nucleus (DMX) neurons projecting to the porcine stomach prepyloric area in the physiological state and after stomach partial resection. J Mol Neurosci 52:90–100 Gozes I, Walker MD, Kaye AM, Littauer UZ (2002) Protein synthesis in nuclei—when did the story start? J Mol Neurosci 18:167–167 Gozes I, Schirer Y, Idan-Feldman A, David M, Furman-Assaf S (2014) NAP alpha-aminoisobutyric acid (IsoNAP). J Mol Neurosci 52:1–9 Joachim SC, Mondon C, Gramlich OW, Grus FH, Dick HB (2014) Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions. J Mol Neurosci 52: 216–224 Kalani A, Kamat PK, Givvimani S, Brown K, Metreveli N, Tyagi SC, Tyagi N (2014) Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid. J Mol Neurosci 52:202–215
J Mol Neurosci (2014) 54:291–292 Kaplan N, Vituri A, Korczyn AD, Cohen OS, Inzelberg R, Yahalom G, Kozlova E, Milgrom R, Laitman Y, Friedman E, Rosset S, HassinBaer S (2014) Sequence variants in SLC6A3, DRD2, and BDNF genes and time to levodopa-induced dyskinesias in Parkinson’s disease. J Mol Neurosci 53:183–188 Kisos H, Ben-Gedalya T, Sharon R (2014) The clathrin-dependent localization of dopamine transporter to surface membranes is affected by alpha-synuclein. J Mol Neurosci 52:167–176 Li XY, Wang ZZ, Liu Y, Zhang RY, Guo XJ, Liu W, Ning CP, Sun LT, Tian JW (2014a) Association of imaging classification of intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke and renalase gene polymorphisms. J Mol Neurosci 52:461–466 Li YF, Peng T, Wang XH, Duan RR, Gao HL, Guan WJ, Teng JF, Jia YJ (2014b) A primary study on down-regulated miR-9-1 and its biological significances in methylmalonic acidemia. J Mol Neurosci 53: 280–286 Liu Y, Ma Y, Zhang B, Wang SX, Wang XM, Yu JM (2014) Genetic polymorphisms in pre-microRNAs and risk of ischemic stroke in a Chinese population. J Mol Neurosci 52:473–480 Lushchekina SV, Nemukhin AV, Varfolomeev SD, Masson P (2014) Molecular modeling evidence for His438 flip in the mechanism of butyrylcholinesterase hysteretic behavior. J Mol Neurosci 52:434–445 Murthy V, Gao Y, Geng LY, LeBrasseur N, White T, Brimijoin S (2014) Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice. J Mol Neurosci 53:409–416 Nicolas G, Rovelet-Lecrux A, Pottier C, Martinaud O, Wallon D, Vernier L, Landemore G, Chapon F, Prieto-Morin C, Tournier-Lasserve E, Frebourg T, Campion D, Hannequin D (2014) PDGFB partial deletion: a new, rare mechanism causing brain calcification with leukoencephalopathy. J Mol Neurosci 53:171–175 Ohno K, Ito M, Kawakami Y, Ohtsuka K (2014) Collagen Q is a Key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis. J Mol Neurosci 53:359–361 Ortuno-Sahagun D, Gonzalez RM, Verdaguer E, Huerta VC, TorresMendoza B, Lemus L, Rivera-Cervantes MC, Camins A, Zarate CB (2014) Glutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of Rat hippocampal neurons in vivo. J Mol Neurosci 52:366–377 Reuss B (2014) Antibodies directed to Neisseria gonorrhoeae impair nerve growth factor-dependent neurite outgrowth in Rat PC12 cells. J Mol Neurosci 52:353–365 Sokolowska P, Urbanska A, Bieganska K, Wagner W, Ciszewski W, Namiecinska M, Zawilska JB (2014) Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci 52:48–55 Wang N, Zhang GF, Liu XY, Sun HL, Wang XM, Qiu LL, Yang C, Yang JJ (2014) Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the Rat brain May contribute to the antidepressant properties of ketamine. J Mol Neurosci 54:211–218 Wu XL, Wang P, Liu YH, Xue YX (2014) Effects of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide on blood-brain barrier and dopaminergic neurons of rats with lipopolysaccharide-induced Parkinson’s disease. J Mol Neurosci 53:1–9 Xu Y, Yang L, Yu SS, Shu QM, Yang C, Wang JW, Xu F, Sang AM, Liang XL (2014) Spatiotemporal changes in NFATc4 expression of retinal ganglion cells after light-induced damage. J Mol Neurosci 53: 69–77 Youssef SM, Mohamed N, Afef S, Khaldoun B, Fadoua N, Fadhel NM, Naceur SM (2014) Combined effects of the C161T and Pro12Ala PPAR gamma 2 gene variants with insulin resistance on metabolic syndrome: a case-control study of a central Tunisian population. J Mol Neurosci 52:487–492 Zhang B, Lu L, Zhang XJ, Ye WY, Wu J, Xi QL, Zhang XJ (2014) HsamiR-132 regulates apoptosis in Non-small cell lung cancer independent of acetylcholinesterase. J Mol Neurosci 53:335–344
Journal of Molecular Neuroscience: Impacting Our Brains Illana Gozes
Published online: 21 October 2014 # Springer Science+Business Media New York 2014
The Journal of Molecular Neuroscience has seen a great expansion of published articles over the last three years and the question is, which are the highly cited articles? In other words, where does molecular neuroscience head these days? The most cited article of all times is by Mattson and colleagues entitled, “Molecular functionalization of carbon nanotubes and use as substrates for neuronal growth” (published 2000 and cited ∼370 times). Lagging behind it is the article by Assaf and colleagues entitled, “Diffusion tensor imaging (DTI)based white matter mapping in brain research: a review” (published 2008 and cited ∼270). In the third place is a paper by Morris and Price entitled: “Pathologic correlates of nondemented aging, mild cognitive impairment, and earlystage Alzheimer’s disease” (published 2001 and cited ∼240 times). These papers make their mark on tissue culture experiments, understanding of brain function by imaging and understanding disease mechanisms. While there are many more highly cited articles including several excellent articles by the Mattson group as well as the discovery of protection against oxidative damage to CNS by alpha-phenyl-tert-butyl-nitrone (PBN) and other spin-trapping agents—a novel series of nonlipid free-radical scavengers, Carney and Floyd, 1991 (cited ∼150 times), a first Cloning, pharmacological characterization, and anatomical distribution of a rat cDNAencoding for a Galanin receptor, Burgevin et al., 1995 and Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier, by Kastin and colleagues, as well as Intracellular mechanisms of amyloid accumulation and
I. Gozes (*) The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, Department of Humana Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel e-mail: [email protected]
pathogenesis in Alzheimer’s disease, by Glabe and colleagues, each cited ∼145 times and published 2001–2002. Moving to 2013, highly impacting articles include 1) Expression Patterns of miR-124, miR-134, miR-132, and miR21 in an Immature Rat Model and Children with Mesial Temporal Lobe Epilepsy, by Peng, Jing; Omran, Ahmed; Ashhab, Muhammad Usman; et al., 2) Aberrant Expression of Long Noncoding RNAs in Autistic Brain, by Ziats, Mark N.; Rennert, Owen M., and 3) Protective Effects of 7,8Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress, by Gupta, Vivek K.; You, Yuyi; Li, Jonathan C.; et al., each cited 12 times. 2014, recently published and already cited, are listed below (Alani et al. 2014; Campanari et al. 2014; Carrion et al. 2014; Chang et al. 2014; Ganko and Calka 2014; Gozes et al. 2014; Joachim et al. 2014; Kalani et al. 2014; Kaplan et al. 2014; Kisos et al. 2014; Li et al. 2014a, b; Liu et al. 2014; Lushchekina et al. 2014; Murthy et al. 2014; Nicolas et al. 2014; Ohno et al. 2014; Ortuno-Sahagun et al. 2014; Reuss 2014; Sokolowska et al. 2014; Wang et al. 2014; Wu et al. 2014; Xu et al. 2014; Youssef et al. 2014; Zhang et al. 2014). My own most cited publication in the Journal of Molecular Neuroscience is entitled as follows: “Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer’s disease at early pathological stage”, from 2007, cited 86 times. In addition, many of publications co-authored by Douglas E. Brenneman (USA) and me, are highly cited. Additional popular citations are of complex linkage analyses, associated with disease mechanisms and pathologies in humans, with many contributions from the J. Oliveira group in Brazil; stem cells and neurodegenerative mechanisms from the D. Offen group in Israel; cytoskeleton and glial cells from the C. Richter-Landsberg group in Germany; and versatile papers in molecular neuroscience by the Soreq group in Israel. Furthermore, in the neuropeptide field, the Shioda group from
292
Japan, the May, Eiden and Loh groups from the USA, and the Reglodi group from Hungary are avid, cited contributors. Obviously, I am missing many, but need to leave something to future editorial notes. The current issue pays tribute to neuropeptides, with the some of the above listed authors. Importantly, this issue pays tribute to Professor Uriel Z. Littauer (Gozes et al. 2002), a mentor to many of us, who passed away recently. Professor Uri Littauer was among the founding pillars of Molecular Neuroscience. We will remember him in follow up issues in 2015 and beyond. With this, I would like to take this opportunity to thank all authors and reviewers for their vital contribution, most importantly, our Editorial Board Members the previous Editors, including, the founder Paul Marangos, Colin J. Barnstable whose publications are highly cited as well as my previous co-editor Mark Mattson (cited above) and the Publishers, Humana Press and Springer. The interest obviously results in new basic and disease mechanisms looking at all aspects of molecular neuroscience. I am looking forward to an exciting 2015!
References Alani B, Salehi R, Sadeghi P, Zare M, Khodagholi F, Arefian E, Hakemi MG, Digaleh H (2014) Silencing of Hsp90 chaperone expression protects against 6-hydroxydopamine toxicity in PC12 cells. J Mol Neurosci 52:392–402 Campanari ML, Garcia-Ayllon MS, Blazquez-Llorca L, Luk WKW, Tsim K, Saez-Valero J (2014) Acetylcholinesterase protein level is preserved in the Alzheimer’s brain. J Mol Neurosci 53:446–453 Carrion M, Juarranz Y, Seoane IV, Martinez C, Gonzalez-Alvaro I, Pablos JL, Gutierrez-Canas I, Gomariz RP (2014) VIP modulates IL-22R1 expression and prevents the contribution of rheumatoid synovial fibroblasts to IL-22-mediated joint destruction. J Mol Neurosci 52: 10–17 Chang P, Dong WW, Zhang MY, Wang ZF, Wang YQ, Wang T, Gao Y, Meng HH, Luo B, Luo CL, Chen XP, Tao LY (2014) Antinecroptosis chemical necrostatin-1 Can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci 52:242–249 Ganko M, Calka J (2014) Localization and chemical coding of the dorsal motor vagal nucleus (DMX) neurons projecting to the porcine stomach prepyloric area in the physiological state and after stomach partial resection. J Mol Neurosci 52:90–100 Gozes I, Walker MD, Kaye AM, Littauer UZ (2002) Protein synthesis in nuclei—when did the story start? J Mol Neurosci 18:167–167 Gozes I, Schirer Y, Idan-Feldman A, David M, Furman-Assaf S (2014) NAP alpha-aminoisobutyric acid (IsoNAP). J Mol Neurosci 52:1–9 Joachim SC, Mondon C, Gramlich OW, Grus FH, Dick HB (2014) Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions. J Mol Neurosci 52: 216–224 Kalani A, Kamat PK, Givvimani S, Brown K, Metreveli N, Tyagi SC, Tyagi N (2014) Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid. J Mol Neurosci 52:202–215
J Mol Neurosci (2014) 54:291–292 Kaplan N, Vituri A, Korczyn AD, Cohen OS, Inzelberg R, Yahalom G, Kozlova E, Milgrom R, Laitman Y, Friedman E, Rosset S, HassinBaer S (2014) Sequence variants in SLC6A3, DRD2, and BDNF genes and time to levodopa-induced dyskinesias in Parkinson’s disease. J Mol Neurosci 53:183–188 Kisos H, Ben-Gedalya T, Sharon R (2014) The clathrin-dependent localization of dopamine transporter to surface membranes is affected by alpha-synuclein. J Mol Neurosci 52:167–176 Li XY, Wang ZZ, Liu Y, Zhang RY, Guo XJ, Liu W, Ning CP, Sun LT, Tian JW (2014a) Association of imaging classification of intracranial cerebral atherosclerotic vascular stenosis in ischemic stroke and renalase gene polymorphisms. J Mol Neurosci 52:461–466 Li YF, Peng T, Wang XH, Duan RR, Gao HL, Guan WJ, Teng JF, Jia YJ (2014b) A primary study on down-regulated miR-9-1 and its biological significances in methylmalonic acidemia. J Mol Neurosci 53: 280–286 Liu Y, Ma Y, Zhang B, Wang SX, Wang XM, Yu JM (2014) Genetic polymorphisms in pre-microRNAs and risk of ischemic stroke in a Chinese population. J Mol Neurosci 52:473–480 Lushchekina SV, Nemukhin AV, Varfolomeev SD, Masson P (2014) Molecular modeling evidence for His438 flip in the mechanism of butyrylcholinesterase hysteretic behavior. J Mol Neurosci 52:434–445 Murthy V, Gao Y, Geng LY, LeBrasseur N, White T, Brimijoin S (2014) Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice. J Mol Neurosci 53:409–416 Nicolas G, Rovelet-Lecrux A, Pottier C, Martinaud O, Wallon D, Vernier L, Landemore G, Chapon F, Prieto-Morin C, Tournier-Lasserve E, Frebourg T, Campion D, Hannequin D (2014) PDGFB partial deletion: a new, rare mechanism causing brain calcification with leukoencephalopathy. J Mol Neurosci 53:171–175 Ohno K, Ito M, Kawakami Y, Ohtsuka K (2014) Collagen Q is a Key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis. J Mol Neurosci 53:359–361 Ortuno-Sahagun D, Gonzalez RM, Verdaguer E, Huerta VC, TorresMendoza B, Lemus L, Rivera-Cervantes MC, Camins A, Zarate CB (2014) Glutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of Rat hippocampal neurons in vivo. J Mol Neurosci 52:366–377 Reuss B (2014) Antibodies directed to Neisseria gonorrhoeae impair nerve growth factor-dependent neurite outgrowth in Rat PC12 cells. J Mol Neurosci 52:353–365 Sokolowska P, Urbanska A, Bieganska K, Wagner W, Ciszewski W, Namiecinska M, Zawilska JB (2014) Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci 52:48–55 Wang N, Zhang GF, Liu XY, Sun HL, Wang XM, Qiu LL, Yang C, Yang JJ (2014) Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the Rat brain May contribute to the antidepressant properties of ketamine. J Mol Neurosci 54:211–218 Wu XL, Wang P, Liu YH, Xue YX (2014) Effects of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide on blood-brain barrier and dopaminergic neurons of rats with lipopolysaccharide-induced Parkinson’s disease. J Mol Neurosci 53:1–9 Xu Y, Yang L, Yu SS, Shu QM, Yang C, Wang JW, Xu F, Sang AM, Liang XL (2014) Spatiotemporal changes in NFATc4 expression of retinal ganglion cells after light-induced damage. J Mol Neurosci 53: 69–77 Youssef SM, Mohamed N, Afef S, Khaldoun B, Fadoua N, Fadhel NM, Naceur SM (2014) Combined effects of the C161T and Pro12Ala PPAR gamma 2 gene variants with insulin resistance on metabolic syndrome: a case-control study of a central Tunisian population. J Mol Neurosci 52:487–492 Zhang B, Lu L, Zhang XJ, Ye WY, Wu J, Xi QL, Zhang XJ (2014) HsamiR-132 regulates apoptosis in Non-small cell lung cancer independent of acetylcholinesterase. J Mol Neurosci 53:335–344
