Cytotherapy, 2014; 16: 101e110
Kinetics of the use of cryopreserved autologous stem cell grafts: a GITMO-SIDEM survey
JACOPO OLIVIERI1, LUCA PIERELLI2, MARTINO INTRONA3, PATRIZIA ACCORSI4, ALBERTO BOSI5, PAOLO PERSEGHIN6, MARCO RISSO7, ANNINO PANDOLFI2, STEFANIA MANCINI1, MONIA MARCHETTI8, SIMONE DAL POZZO5, ELISA GOTTI3, ALESSANDRO RAMBALDI3, PIETRO LEONI1 & ATTILIO OLIVIERI1, ON BEHALF OF THE GITMO (GRUPPO ITALIANO TRAPIANTO DI MIDOLLO OSSEO)eSIDEM (SOCIETÀ ITALIANA DI EMAFERESI E MANIPOLAZIONE CELLULARE) WORKING GROUP ON SCU DISPOSAL 1
Hematology Clinic, Marche Polytechnic University, Ancona, Italy, 2Immunohematology and Transfusion Unit, Azienda Ospedaliera San Camillo-Forlanini and Università di Roma-La Sapienza, Roma, Italy, 3The Hematology and Bone Marrow Transplant Units of Ospedali Riuniti di Bergamo, Bergamo, Italy, 4Immunohematology and Transfusion, Apheresis Unit, Azienda Ospedaliera Santo Spirito, Pescara, Italy, 5Haematology Department, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy, 6Transfusional Center, Apheresis and Criobiology Unit, San Gerardo Hospital, Monza, Italy, 7Immunohematology and Transfusion Unit, IRCCS Giannina Gaslini, Genova, Italy, 8 Internal Medicine Unit, Cardinal Massaia Hospital, Asti, Italy Abstract Background aims. Hematopoietic stem cell cryopreservation significantly contributed to autologous stem cell transplantation (ASCT). Cryopreserved stem cell units (SCU) are expected to be used soon after harvesting for most purposes, but, in a number of cases, they remain stored for some time, creating an increasing load for SCU depositories. Disposal policies vary widely in each center, and the existing guidelines are insufficient. Methods. We conducted a survey of seven Gruppo Italiano Trapianto di Midollo Osseo centers to investigate the outcome of SCU harvested from January 2005 to December 2009 for ASCT. The data from 1603 collections were gathered, for a total of 5822 SCU. Results. In our cohort, 79% of patients collected >5 106 CD34þ cells/kg, and 3.4% collected
Kinetics of the use of cryopreserved autologous stem cell grafts: a GITMO-SIDEM survey
JACOPO OLIVIERI1, LUCA PIERELLI2, MARTINO INTRONA3, PATRIZIA ACCORSI4, ALBERTO BOSI5, PAOLO PERSEGHIN6, MARCO RISSO7, ANNINO PANDOLFI2, STEFANIA MANCINI1, MONIA MARCHETTI8, SIMONE DAL POZZO5, ELISA GOTTI3, ALESSANDRO RAMBALDI3, PIETRO LEONI1 & ATTILIO OLIVIERI1, ON BEHALF OF THE GITMO (GRUPPO ITALIANO TRAPIANTO DI MIDOLLO OSSEO)eSIDEM (SOCIETÀ ITALIANA DI EMAFERESI E MANIPOLAZIONE CELLULARE) WORKING GROUP ON SCU DISPOSAL 1
Hematology Clinic, Marche Polytechnic University, Ancona, Italy, 2Immunohematology and Transfusion Unit, Azienda Ospedaliera San Camillo-Forlanini and Università di Roma-La Sapienza, Roma, Italy, 3The Hematology and Bone Marrow Transplant Units of Ospedali Riuniti di Bergamo, Bergamo, Italy, 4Immunohematology and Transfusion, Apheresis Unit, Azienda Ospedaliera Santo Spirito, Pescara, Italy, 5Haematology Department, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy, 6Transfusional Center, Apheresis and Criobiology Unit, San Gerardo Hospital, Monza, Italy, 7Immunohematology and Transfusion Unit, IRCCS Giannina Gaslini, Genova, Italy, 8 Internal Medicine Unit, Cardinal Massaia Hospital, Asti, Italy Abstract Background aims. Hematopoietic stem cell cryopreservation significantly contributed to autologous stem cell transplantation (ASCT). Cryopreserved stem cell units (SCU) are expected to be used soon after harvesting for most purposes, but, in a number of cases, they remain stored for some time, creating an increasing load for SCU depositories. Disposal policies vary widely in each center, and the existing guidelines are insufficient. Methods. We conducted a survey of seven Gruppo Italiano Trapianto di Midollo Osseo centers to investigate the outcome of SCU harvested from January 2005 to December 2009 for ASCT. The data from 1603 collections were gathered, for a total of 5822 SCU. Results. In our cohort, 79% of patients collected >5 106 CD34þ cells/kg, and 3.4% collected
