42 I would suggest it is
more relevant always to remember the of ectopic or a hydatidiform mole in any patient who has been investigated for infertility, than it is to suggest that those who have had clomiphene are especially at risk.
possibility
tine chemotherapy ration :
Advanced disease
New Medical School, Liverpool L69 3BX
MICHAEL BURKE
CHEMOTHERAPY AFTER MASTECTOMY
SIR,-Even in clinically early cases breast carcinoma is often disseminated beyond the reach of surgery’ so the value of adjuvant chemotherapy requires serious consideration. We would like to report the survival-rates of patients who received a prolonged course (4-6 months) of cyclophosphamide mouth immediately after extended local (100-200 mg daily) by mastectomy. These patients were seen consecutively in the same surgical practice (D.M.M.) in the period 1964-65. The 10-year survival of these patients has been compared with that of patients treated in the same practice between 1957 and 1963 who had either no chemotherapy or a single intravenous injection of cyclophosphamide or thiotepa at operation:
Advanced disease
Total 78 51 38
All stages
167
53
(32%)
Total 20 20 6 46
1964-65 Survivors 16 (80%) 7 (35%) 1 24
(52%)
The survival-rate of the node-negative patients is significantly better in the 1964-65 group (x2 with Yates’ correction 7.6, P
more relevant always to remember the of ectopic or a hydatidiform mole in any patient who has been investigated for infertility, than it is to suggest that those who have had clomiphene are especially at risk.
possibility
tine chemotherapy ration :
Advanced disease
New Medical School, Liverpool L69 3BX
MICHAEL BURKE
CHEMOTHERAPY AFTER MASTECTOMY
SIR,-Even in clinically early cases breast carcinoma is often disseminated beyond the reach of surgery’ so the value of adjuvant chemotherapy requires serious consideration. We would like to report the survival-rates of patients who received a prolonged course (4-6 months) of cyclophosphamide mouth immediately after extended local (100-200 mg daily) by mastectomy. These patients were seen consecutively in the same surgical practice (D.M.M.) in the period 1964-65. The 10-year survival of these patients has been compared with that of patients treated in the same practice between 1957 and 1963 who had either no chemotherapy or a single intravenous injection of cyclophosphamide or thiotepa at operation:
Advanced disease
Total 78 51 38
All stages
167
53
(32%)
Total 20 20 6 46
1964-65 Survivors 16 (80%) 7 (35%) 1 24
(52%)
The survival-rate of the node-negative patients is significantly better in the 1964-65 group (x2 with Yates’ correction 7.6, P
