*XIL (amoxicillin)

The new generation broad-spectrum penicillin INDICATIONS AND DOSAGE Infections of the ear, nose and throat due to streptococci, pneumococci, and penicillinsensitive staphylococci; infections of the upper respiratory tract due to H. influenzae; infections of the genitourinary tract due to E. coli, P. mirabilis, and S. faecalis; infections of the skin and soft tissues due to streptococci, penicillin-sensitive staphylococci and E. coli: USUAL DOSE: ADULTS 250 mg every 8 hours CHILDREN 25 mg/kg/day in divided doses every 8 hours In severe infections or infection associated with organisms where sensitivity determinations indicate higher blood levels may be advisable: 500 mg every 8 hours for adults, and 50 mg/kg/day in divided doses every 8 hours for children may be needed. This dosage should not exceed the recommended adult dosage. Infections of the lower respiratory tract due to streptococci, pneumococci, penicillinsensitive staphylococci and H. influenzae: USUAL DOSE: ADULTS 500 mg every 8 hours CHILDREN 50mg/kg/day in divided doses every 8 hours This dosage should not exceed the recommended adult dosage. Ur.thritis due to N. gonorrhoeae: 3 g as a single oral dose. CONTRAINDICATION In patients with a history of allergy to the penicillins and cephalosporins. Product Monograph available on request. SUPPLIED AMOXIL-250 Capsules-each contains 250 mg amoxicillin (as the trihydrate) AMOXIL-SQO Capsules-each contains 500 mg amoxicillin (as the trihydrate) AMOXIL-125 Suspension-125 mg amoxicillin per 5 ml, in 75 ml & 100 ml bottles AMOXIL-250 Suspension-250 mg amoxicillin per 5 ml, in 75 ml & 100 ml bottles AMOXIL Pediatric Drops-is ml (50 mg/mI) in dropper bottle


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AYERST LABORATORIES Division of Ayerst, McKenna & Harrison Limited Montreal, Canada Made in Canada by arrangement with BEECHAM, INC. .Reg'd


carried out by Ms. Warbick. However, there have been other reports on the size of colloidal gold particles; one source states that their diameter ranges from 3 to 25 nm.1 In two French papers it is claimed that 50Y-citrate is composed of micelles, most of which are less than 10 nm1 or 30 nm3 in diameter, and another paper reported that . citrate from France contained particles with a diameter of 10 to 30 nm.4 We accept that further studies on our 90Y-citrate colloid would strengthen the case for its similarity in particle size to colloidal gold. Nevertheless, we believe from previous reports that it is unlikely that our formulation is fundamentally different from that of other workers. B.M. BOWEN, M Sc PHM J. DARRACOTT, MB, D PHYS MED, FRCP[C] E.S. GARNETF, MB, MRCP

R.H. TOMLINSON, PH 0 McMaster University Medical Centre

1200 Main St. w Hamilton, ON

References 1. BELcHER EH, VETrER H: Radloisotopes in Medical Diagnosis, London, Butterworth,

1971, p 523 2. BONTOUX MMJ. MARIGNAN R. BALI JP: ttude dimensionnelle du colloide de citrate d'yttrium radioactif. Ann Phys Biol Med 2: 93, 1968 3. DELBARRE F, CAYELA J, MENKES C, et al:

La synoviorth.se par les radioisotopes. Presse Med 76: 1045, 1968


our, reflected in a changing pattern of presentation of venereal disease.8 These considerations raise an important question relating to the risk of PID with the IUD - namely, does the pattern of sexual behaviour of an individual or couple affect the woman's risk for PID? Only one study to date has considered this question.5 Detailed studies should be made of the patterns of sexual behaviour of women with an IUD to identify those at risk before a device is inserted. w.E. SEIDELMAN, MD

REACH Centre 1144 Commercial Dr. Vancouver, BC

References I. Guidelines for the use of intrauterine contraceptive devices. Rx Bull 6: 28, 1975 2. CHRISTIAN CD: Maternal deaths associated with an intrauterine device. Am J Obstet Gynecol 119: 441, 1974 3. wRIGHT NH: Acute pelvic inflammatory disease in an indigent population. Am J Obstet Gynecol 101: 979, 1968 4. HANDSFIELD NH: Reported in International Symposium on Gonorrhea, GODDEN JO (ed). Can Med Assoc J 109: 1046, 1973 5. TAROUM SD, WRIGHT NH: Association of the intrauterine device and pelvic inflammatory disease: a retrospective pilot study. Am J Epidemiol 100: 262, 1974 6. NOONAN AS, ADAMS JB: Gonorrhea screening in an urban hospital family planning program. Am J Public Health 64: 700, 1974 7. E5CHENBACH DA, HOLMES KK: Acute pelvic inflammatory disease: current concepts on pathogenesis, etiology, and management. Clin Obstet Gynecol 18: 35, 1975 8. Venereal disease in Massachusetts - changing patterns. N Engl J Med 293: 1150, 1975

Use of yttrium-90 in persistent synovitis of the knee. Ann Rheum Dis 33: 126, 1974

Calamity averted The IUD and PID To the editor: The recent article published by the health protection branch of Health and Welfare Canada entitled "Guidelines for the use of intrauterine contraceptive devices" contains much useful information on the prevention and management of problems associated with that form of contraception.1 The guidelines deal with pathologic problems and factors that have previously been identified as hazards contraindicating the use of the device or necessitating its removal. Despite this information there remain a number of unanswered questions relating to the problem of infection. The reports in 1974 of infection in pregnant women with an LUD resulted in reassessment of this contraceptive.2 In addition, many practitioners have become increasingly concerned about the apparent increase in pelvic inflammatory disease (PID) in nonpregnant women with the . Assessment of the use of the TUD appears to be at a critical point, where its advantages and risks are being weighed by both practitioners and patients. The reintroduction of the IUD in the 1960s coincided with an apparent change in sexual attitudes and behavi-

To the editor: Dr. Swinton's account of the life of the celebrated medical truant, Sir Arthur Conan Doyle (Can Med Assoc J 113: 989, 1975) brims with information, and one would be hard put to it to find any important lacunae. However, for those of us who are avid skiers it is of consummate interest to know it was Conan Doyle who was instrumental in making skiing a popular sport. The time was 1893, that terrible year when Professor Moriarty threw Sherlock Holmes into the awesome falls of Reichenbach. To the incredulous Swiss citizens who smiled sceptically when seeing the massive Britisher attempting to glide over the snows and ice of Switzerland on miniature sticks, or what the Norwegians called skis, he said, "The time will come when hundreds of Englishmen will come to Switzerland for a skiing season." One shudders even to think of such a calamity, but had the people of London taken more kindly to Conan Doyle's bedside manner we might never have had the exploits of the world's greatest detective or the manifold delights of its most adventuresome sport. PHILIP EISEL, MD, s'ics[c]

5845 C6te des Neiges Montreal, PQ

CMA JOURNAL/APRIL 3, 1976/VOL. 114 601

Letter: The IUD and PID.

U *XIL (amoxicillin) The new generation broad-spectrum penicillin INDICATIONS AND DOSAGE Infections of the ear, nose and throat due to streptococci,...
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