657 We have measured the salivary concentrations of carbamazepine after single oral doses in five healthy volunteers using gas-chromatography. The drug is separated on a column ofto5%a ’Apiezon L’ 1% KOH on ’Diatomite CLQ’ connected nitrogen detector. Mixed saliva samples were obtained by mechanical stimulation. The concentration in these samples at 3, 5, 8, 24, 28, 32, 48, 96, and 120 h after taking the dose orally was 31± 0.7%

(mean±s.D., n=36) of the corresponding plasma

concentra-

tion. Throughout the range measured the concentrations in saliva and plasma showed excellent agreement (see figure). Although carbamazepine is bound to plasma protein, there was close correlation (r=0.95, r