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OPEN
received: 05 January 2016 accepted: 13 June 2016 Published: 30 June 2016
Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma Kosuke Saito1,*, Eri Arai2,3,*, Keiko Maekawa1, Masaki Ishikawa1, Hiroyuki Fujimoto4, Ryo Taguchi1, Kenji Matsumoto5, Yae Kanai2,3 & Yoshiro Saito1 Renal cell carcinoma (RCC) is the most common histological type of adult kidney cancer. In this study, we obtained lipidomic profiles of clear cell RCC (ccRCC), a major RCC subtype, by performing a lipidomic analysis of specimens of cancerous tissue and the surrounding normal renal cortex obtained from the same patients (N = 49). We also compared the lipidomic profiles with the lipogenic transcriptome of specimens of cancerous tissue and the surrounding normal renal cortex for an additional set of patient samples (N = 95). Overall, we detected 326 lipids, including phospholipids, sphingolipids, neutral lipids, and eicosanoids. The levels of more than 70% of the detected lipids were significantly different (P
OPEN
received: 05 January 2016 accepted: 13 June 2016 Published: 30 June 2016
Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma Kosuke Saito1,*, Eri Arai2,3,*, Keiko Maekawa1, Masaki Ishikawa1, Hiroyuki Fujimoto4, Ryo Taguchi1, Kenji Matsumoto5, Yae Kanai2,3 & Yoshiro Saito1 Renal cell carcinoma (RCC) is the most common histological type of adult kidney cancer. In this study, we obtained lipidomic profiles of clear cell RCC (ccRCC), a major RCC subtype, by performing a lipidomic analysis of specimens of cancerous tissue and the surrounding normal renal cortex obtained from the same patients (N = 49). We also compared the lipidomic profiles with the lipogenic transcriptome of specimens of cancerous tissue and the surrounding normal renal cortex for an additional set of patient samples (N = 95). Overall, we detected 326 lipids, including phospholipids, sphingolipids, neutral lipids, and eicosanoids. The levels of more than 70% of the detected lipids were significantly different (P
