Original Paper
Nephron 1992:62:31-35
P. Cappelli M. Evangelista M. Bonomini P.F. Pahnieri A. Albertazzi
Lipids in the Progression of Chronic Renal Failure
Institute of Nephrology, University of Chieti. Italy
Key Words Apolipoproteins Chronic renal failure Lipids Urinary protein excretion
Abstract Lipid disturbances have been linked to the progression of chronic renal disease. We examined 52 patients with a creatinine clearance (C C r)of38.5± 7.9 ml/min due to various nephropathies, on free diet. Bimonthly, over a 12-month period, we assessed: serum creatinine (Cr); CCr; daily urinary urea excretion; urinary protein excretion per unit of residual renal function (UProt/CCr); total, HDL, VLDLand LDL cholesterol; triglycerides; Apo A. Apo B. Chronic renal failure was progressive in 22 patients with a slope of l/Cr-0.00358± 0.00247, stable in 30 with a slope o f0.00420 ± 0.00285. Lipid parameters did not differ significantly between the two groups but for the lower Apo A and Apo A/Apo B ratio values in the progressive group. Overall slope inversely correlated with basal CCr; in the progressive patients the slope correlated w'ith the percentage variation of UProt/CCr and only partially with the altered Apo profile.
Introduction In the last years many experimental and clinical studies [1-5] have been undertaken to better understand the patho physiology of progressive chronic renal failure (CRF). Re cently it has been hypothesized that a common mechanism leading to generalized atherosclerosis and to progressive glomerulosclerosis up to end-stage renal failure may exist
accepted in animals, the role of lipids in producing progres sive renal damage in humans has not been conclusively clarified [13-17], The aim of this study was to examine the possible role of dyslipidemia in the progression of CRF in humans.
Patients and Methods
[6- 8],
Accepted October 31.1991
We studied 52 patients (37 males, 15 females; age 31 61 years) with a creatinine clearance (CCr) o f60-20 ml/min (mean 38.5 ±7.9) due to various nephropathies: chronic glomerulonephritis (CGN) 15 cases: chronic tubulointerstitial nephropathy (C'TIN) 22 cases: nephroscler osis (NS) 8 cases: single kidney (SK) 7 cases. Patients with nephrotic syndrome, diabetes mellitus. liver diseases, thyroid dysfunction, alco hol abuse and steroid or immunosuppressive therapy were excluded. All patients were on a completely free diet. When necessary, they were given pharmacological treatment with diuretics, antihypertensives (beta blockers, calcium antagonists, clonidine) to keep blood pressure
Nephron 1992:62:31-35
P. Cappelli M. Evangelista M. Bonomini P.F. Pahnieri A. Albertazzi
Lipids in the Progression of Chronic Renal Failure
Institute of Nephrology, University of Chieti. Italy
Key Words Apolipoproteins Chronic renal failure Lipids Urinary protein excretion
Abstract Lipid disturbances have been linked to the progression of chronic renal disease. We examined 52 patients with a creatinine clearance (C C r)of38.5± 7.9 ml/min due to various nephropathies, on free diet. Bimonthly, over a 12-month period, we assessed: serum creatinine (Cr); CCr; daily urinary urea excretion; urinary protein excretion per unit of residual renal function (UProt/CCr); total, HDL, VLDLand LDL cholesterol; triglycerides; Apo A. Apo B. Chronic renal failure was progressive in 22 patients with a slope of l/Cr-0.00358± 0.00247, stable in 30 with a slope o f0.00420 ± 0.00285. Lipid parameters did not differ significantly between the two groups but for the lower Apo A and Apo A/Apo B ratio values in the progressive group. Overall slope inversely correlated with basal CCr; in the progressive patients the slope correlated w'ith the percentage variation of UProt/CCr and only partially with the altered Apo profile.
Introduction In the last years many experimental and clinical studies [1-5] have been undertaken to better understand the patho physiology of progressive chronic renal failure (CRF). Re cently it has been hypothesized that a common mechanism leading to generalized atherosclerosis and to progressive glomerulosclerosis up to end-stage renal failure may exist
accepted in animals, the role of lipids in producing progres sive renal damage in humans has not been conclusively clarified [13-17], The aim of this study was to examine the possible role of dyslipidemia in the progression of CRF in humans.
Patients and Methods
[6- 8],
Accepted October 31.1991
We studied 52 patients (37 males, 15 females; age 31 61 years) with a creatinine clearance (CCr) o f60-20 ml/min (mean 38.5 ±7.9) due to various nephropathies: chronic glomerulonephritis (CGN) 15 cases: chronic tubulointerstitial nephropathy (C'TIN) 22 cases: nephroscler osis (NS) 8 cases: single kidney (SK) 7 cases. Patients with nephrotic syndrome, diabetes mellitus. liver diseases, thyroid dysfunction, alco hol abuse and steroid or immunosuppressive therapy were excluded. All patients were on a completely free diet. When necessary, they were given pharmacological treatment with diuretics, antihypertensives (beta blockers, calcium antagonists, clonidine) to keep blood pressure
