Original Research Lipoprotein(a) and Risk of Myocardial Infarction and Death in Chronic Kidney Disease Findings From the CRIC Study (Chronic Renal Insufficiency Cohort) Archna Bajaj, Scott M. Damrauer, Amanda H. Anderson, Dawei Xie, Matthew J. Budoff, Alan S. Go, Jiang He, James P. Lash, Akinlolu Ojo, Wendy S. Post, Mahboob Rahman, Muredach P. Reilly, Danish Saleheen, Raymond R. Townsend, Jinbo Chen, Daniel J. Rader; the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators*
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Objective—To investigate the effect of LPA gene variants and renal function on lipoprotein(a) [Lp(a)] levels in people with chronic kidney disease and determine the association between elevated Lp(a) and myocardial infarction and death in this setting. Approach and Results—The CRIC Study (Chronic Renal Insufficiency Cohort) is an ongoing prospective study of 3939 participants with chronic kidney disease. In 3635 CRIC participants with genotype data, carriers of the rs10455872 or rs6930542 variants had a higher median Lp(a) level (mg/dL) compared with noncarriers (73 versus 23; P
Downloaded from http://atvb.ahajournals.org/ by guest on August 25, 2017
Objective—To investigate the effect of LPA gene variants and renal function on lipoprotein(a) [Lp(a)] levels in people with chronic kidney disease and determine the association between elevated Lp(a) and myocardial infarction and death in this setting. Approach and Results—The CRIC Study (Chronic Renal Insufficiency Cohort) is an ongoing prospective study of 3939 participants with chronic kidney disease. In 3635 CRIC participants with genotype data, carriers of the rs10455872 or rs6930542 variants had a higher median Lp(a) level (mg/dL) compared with noncarriers (73 versus 23; P
