Cancvr 6e~m~. 5 {1978) 139--144 © E~lsevier/Nor~h-~lolla~dNcien~d]cPublishem Lt, 1.

] 39

LIVE ~1;ORlg1TkgN~, I>ECARBOXYLASE lNIR~.~lG. ?i-t~INO,~Af~Br:r AL PR,OI~I~OTK)N O F N I T R O S A . ~ E N E CA~,CINOGEN~'ISIS

D.C. FAR,WELL*, C.N. N O L A N and E.J.IIEI~;BS'['** Dep~rD~l,~nt o f Bioe.hemislr,~, Unlver~zty o f New t, atv~h~re. D~rham. Nel '~Hampshire ,03824 OrJS.A.)

(Reeeiv~ ~' 17 ,April 1978) (Re~se~ ve~on received 2~, May ] S,78) (Aeeept~ld 31 May 1978)

S[r~//MA~I',3 r ?~ae incidence of liver t~mors reduced in rats by N-diethylnitr~ ,samme w ~ increased by the feeding o~ phenobarbital. Liv~ ormt,hine dec arboxylase ~ t i v i t y did n o t increase in m~,dmalsrecei~m g ph~ nob~rb~ml in the die~, and t/~,., concenSw-~t,on of polyamines in the liver w~u~similarly unchanged. No relation ship be'l,~reeu the pzomo~l,ion c,f N-nitro~am me-induced hver t,~uno~s by phenobarbital m~d the omithine dec~trboxylase a¢ fixity of the liwm"~as ~~dicated by the.~e e:¢pen;~el,ts.

INTI~,ODUCT ION The feedhg o f pheno~barbital to zats ate,or the admimstrati,~n of 2 ace~,Tlaminofluorcne (AA F,~ enh~a~ced hepatic ~x~morig~mesls [ ~,7 ]. Phial