Vol. 34, No. 1
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 1990, p. 17-20
0066-4804/90/010017-04$02.00/0 Copyright ) 1990, American Society for Microbiology
Lomefloxacin Pharmacokinetics in Subjects with Normal and Impaired Renal Function A. LEROY,'* J. P. FILLASTRE,2 AND G. HUMBERT3 Departments of Biochemistry,' Nephrology,2 and Infectious Diseases,3 University of Rouen, H6pital Charles Nicolle, 76031 Rouen, France Received 14 February 1989/Accepted 7 October 1989
Lomefloxacin pharmacokinetics were investigated in 6 normal subjects and 24 uremic patients after a single oral dose of 400 mg. In subjects with normal renal function, the peak level in plasma averaged 3.5 0.9 ,g/ml (mean + standard deviation) and was obtained at 1.3 0.9 h. The absorption rate constant was 3.8 1.6 h-'. The terminal half-life was 7.77 0.95 h. The apparent volume of distribution was 2.54 0.66 liters/kg. Total body and renal dearances were 259 ± 83 and 200 ± 55 ml/min per 1.73 m2, respectively. The percentage of the dose recovered unchanged in 48-h urine was 80.6 2.8. In uremic patients, the terminal half-life increased in relation to the degree of renal failure: from 8 h in normal subjects to 38 h in severely uremic patients (glomerular filtration rate,
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 1990, p. 17-20
0066-4804/90/010017-04$02.00/0 Copyright ) 1990, American Society for Microbiology
Lomefloxacin Pharmacokinetics in Subjects with Normal and Impaired Renal Function A. LEROY,'* J. P. FILLASTRE,2 AND G. HUMBERT3 Departments of Biochemistry,' Nephrology,2 and Infectious Diseases,3 University of Rouen, H6pital Charles Nicolle, 76031 Rouen, France Received 14 February 1989/Accepted 7 October 1989
Lomefloxacin pharmacokinetics were investigated in 6 normal subjects and 24 uremic patients after a single oral dose of 400 mg. In subjects with normal renal function, the peak level in plasma averaged 3.5 0.9 ,g/ml (mean + standard deviation) and was obtained at 1.3 0.9 h. The absorption rate constant was 3.8 1.6 h-'. The terminal half-life was 7.77 0.95 h. The apparent volume of distribution was 2.54 0.66 liters/kg. Total body and renal dearances were 259 ± 83 and 200 ± 55 ml/min per 1.73 m2, respectively. The percentage of the dose recovered unchanged in 48-h urine was 80.6 2.8. In uremic patients, the terminal half-life increased in relation to the degree of renal failure: from 8 h in normal subjects to 38 h in severely uremic patients (glomerular filtration rate,
