CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2014; 20: 2228-2234 DOI: 10.12659/MSM.892315

Long-Term Cholecalciferol Administration in Hemodialysis Patients: A Single-Center Randomized Pilot Study

Received: 2014.08.25 Accepted: 2014.09.25 Published: 2014.11.10

Authors’ Contribution: Study Design  A Data Collection  B Analysis  C Statistical Data Interpretation  D Manuscript Preparation  E Literature Search  F Collection  G Funds

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Mariusz Mieczkowski Paweł Żebrowski Ewa Wojtaszek Tomasz Stompór Jerzy Przedlacki Zbigniew Bartoszewicz Janusz Sierdziński Zofia Wańkowicz Stanisław Niemczyk Joanna Matuszkiewicz-Rowińska

1 Department of Nephrology, Dialysis and Internal Diseases, Medical University of Warsaw, Warsaw, Poland 2 Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland 3 Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland 4 Department of Informatics, Medical University of Warsaw, Warsaw, Poland 5 Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, Warsaw, Poland

Joanna Matuszkiewicz-Rowińska, e-mail: [email protected] Departmental sources

Data on the potent pleiotropic extraskeletal effects of vitamin D have renewed interest in its use in selected populations, including patients with chronic kidney disease, but the available data are still insufficient to make recommendations. This study assessed the long-term effect of small cholecalciferol doses on serum vitamin D, parathormone (PTH), and bone mineral density (BMD) in hemodialysis patients. Nineteen patients with serum 25(OH)D