CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 3500-3505 DOI: 10.12659/MSM.896344
Low Pretreatment Acoustic Radiation Force Impulse Imaging (ARFI) Values Predict Sustained Virological Response in Antiviral Hepatitis C Virus (HCV) Therapy
Received: 2015.10.19 Accepted: 2016.03.22 Published: 2016.09.30
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
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Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
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Steffen Zopf Lara Rösch Peter C. Konturek Ruediger S. Goertz Markus F. Neurath Deike Strobel
1 Medical Department 1, University of Erlangen-Nuremberg, Erlangen, Germany 2 Department of Internal Medicine 2, Thüringen Kliniken „Georgius Agricola“, Saalfeld, Germany
Steffen Zopf, e-mail: [email protected] Departmental sources
Non-invasive procedures such as acoustic radiation force impulse imaging (ARFI) shear-wave elastography are currently used for the assessment of liver fibrosis. In the course of chronic hepatitis C, significant liver fibrosis or cirrhosis develops in approximately 25% of patients, which is a negative predictor of antiviral treatment response. Cirrhosis can be prevented by successful virus elimination. In this prospective study, a pretreatment ARFI cutoff value of 1.5 m/s was evaluated in relation to sustained virological response to anti-HCV therapy. In 23 patients with chronic hepatitis C, liver stiffness was examined with ARFI at defined times before and under antiviral triple therapy (peginterferon, ribavirin in combination with a first-generation protease inhibitor, and telaprevir or boceprevir). Patients were stratified into 2 groups based on pretreatment ARFI values (
Low Pretreatment Acoustic Radiation Force Impulse Imaging (ARFI) Values Predict Sustained Virological Response in Antiviral Hepatitis C Virus (HCV) Therapy
Received: 2015.10.19 Accepted: 2016.03.22 Published: 2016.09.30
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Collection G Funds
ABCDEF 1 BCDEF 1 CDE 2 BCD 1 ACDE 1 ABCDE 1
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Steffen Zopf Lara Rösch Peter C. Konturek Ruediger S. Goertz Markus F. Neurath Deike Strobel
1 Medical Department 1, University of Erlangen-Nuremberg, Erlangen, Germany 2 Department of Internal Medicine 2, Thüringen Kliniken „Georgius Agricola“, Saalfeld, Germany
Steffen Zopf, e-mail: [email protected] Departmental sources
Non-invasive procedures such as acoustic radiation force impulse imaging (ARFI) shear-wave elastography are currently used for the assessment of liver fibrosis. In the course of chronic hepatitis C, significant liver fibrosis or cirrhosis develops in approximately 25% of patients, which is a negative predictor of antiviral treatment response. Cirrhosis can be prevented by successful virus elimination. In this prospective study, a pretreatment ARFI cutoff value of 1.5 m/s was evaluated in relation to sustained virological response to anti-HCV therapy. In 23 patients with chronic hepatitis C, liver stiffness was examined with ARFI at defined times before and under antiviral triple therapy (peginterferon, ribavirin in combination with a first-generation protease inhibitor, and telaprevir or boceprevir). Patients were stratified into 2 groups based on pretreatment ARFI values (
