Tumor Biol. DOI 10.1007/s13277-014-1953-6
RESEARCH ARTICLE
LRG1 is an independent prognostic factor for endometrial carcinoma Shan-Yun Wen & Li-Na Zhang & Xiao-Mei Yang & Yan-Li Zhang & Li Ma & Qiu-Lin Ge & Shu-Heng Jiang & Xiao-Lu Zhu & Wei Xu & Wen-Jing Ding & Bing-Qing Yang & Zhi-Gang Zhang & Yin-Cheng Teng
Received: 13 February 2014 / Accepted: 7 April 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014
Abstract Endometrial cancer (EC) is one of the most common female malignancies. The patients with high-risk factors may have poor prognosis. Therefore, there is an urgent need to find a new molecule to more accurately predict survival of patients. Leucine-rich-alpha-2-glycoprotein1 (LRG1), one of leucine-rich repeat family, was closely associated with cancer metastasis and poor prognosis. The biological functions and the expression level of LRG1 remain obscure in EC. In this study, by immunohistochemical analysis of 242 EC patient tissues, we found that LRG1 expression was associated with stage and lymphatic metastasis in both test cohort (133 Shan-Yun Wen and Li-Na Zhang contributed equally to this work. S.
RESEARCH ARTICLE
LRG1 is an independent prognostic factor for endometrial carcinoma Shan-Yun Wen & Li-Na Zhang & Xiao-Mei Yang & Yan-Li Zhang & Li Ma & Qiu-Lin Ge & Shu-Heng Jiang & Xiao-Lu Zhu & Wei Xu & Wen-Jing Ding & Bing-Qing Yang & Zhi-Gang Zhang & Yin-Cheng Teng
Received: 13 February 2014 / Accepted: 7 April 2014 # International Society of Oncology and BioMarkers (ISOBM) 2014
Abstract Endometrial cancer (EC) is one of the most common female malignancies. The patients with high-risk factors may have poor prognosis. Therefore, there is an urgent need to find a new molecule to more accurately predict survival of patients. Leucine-rich-alpha-2-glycoprotein1 (LRG1), one of leucine-rich repeat family, was closely associated with cancer metastasis and poor prognosis. The biological functions and the expression level of LRG1 remain obscure in EC. In this study, by immunohistochemical analysis of 242 EC patient tissues, we found that LRG1 expression was associated with stage and lymphatic metastasis in both test cohort (133 Shan-Yun Wen and Li-Na Zhang contributed equally to this work. S.
