Clin. exp. Immunol. (1977) 30, 56-61.
Lymphocytotoxins in epileptic patients receiving phenytoin B. S. 00I, K. S. KANT, I. B. HANENSON, A. J. PESCE & V. E. POLLAK Divisions of Nephrology and Clinical Pharmacology, Department of Internal Medicine, University of Cincinnati College oJ Medicine, Cincinnati, Ohio, U.S.A.
(Received 1 April 1977) SUMMARY
The present study was undertaken to determine the prevalence and nature of lymphocytotoxic antibodies in patients receiving phenytoin. Of forty-six sera examined, lymphocytotoxins and antinuclear antibodies were detected in fourteen and eleven samples respectively. Antibodies to double-stranded RNA (poly-A-poly-U) were found in six out of thirty-eight sera studied. A highly significant correlation was found between the presence of lymphocytotoxins and antinuclear antibodies (x2 = 9X72; P
Lymphocytotoxins in epileptic patients receiving phenytoin B. S. 00I, K. S. KANT, I. B. HANENSON, A. J. PESCE & V. E. POLLAK Divisions of Nephrology and Clinical Pharmacology, Department of Internal Medicine, University of Cincinnati College oJ Medicine, Cincinnati, Ohio, U.S.A.
(Received 1 April 1977) SUMMARY
The present study was undertaken to determine the prevalence and nature of lymphocytotoxic antibodies in patients receiving phenytoin. Of forty-six sera examined, lymphocytotoxins and antinuclear antibodies were detected in fourteen and eleven samples respectively. Antibodies to double-stranded RNA (poly-A-poly-U) were found in six out of thirty-eight sera studied. A highly significant correlation was found between the presence of lymphocytotoxins and antinuclear antibodies (x2 = 9X72; P
