Pharmac. Ther. Vol. 51, pp. 195-216, 1991 Printed in Great Britain. All rights reserved
0163-7258/91 $0.00 + 0.50 © 1991 Pergamon Press lalc
Specialist Subject Editor: R. AUERBACH
MACROPHAGE-DERIVED ANGIOGENESIS FACTORS CORD SUNDERKOTTER,* MATTHIAS GOEBELER,* KLAUS SCHULZE-OsTHOFF,~ RANJIT BHARDWAJ* a n d CLEMENS SORG* *Institute of Experimental Dermatology, University of Miinster, Von-Esmarch-Strasse 56, D-W-4400 Miinster, Germany t lnstitute of Molecular Biology, Rijksuniversiteit Gent, Belgium Abstract--A majority of angiogenic factors has been shown to be produced by macrophages. This review will give a concise description of their biochemical nature, their isolation from macrophages and their angiogenic activity. Among the factors with mitogenic effects on endothelial cells are basic fibroblast growth factor (bFGF), transforming growth factor-alpha (TGF
0163-7258/91 $0.00 + 0.50 © 1991 Pergamon Press lalc
Specialist Subject Editor: R. AUERBACH
MACROPHAGE-DERIVED ANGIOGENESIS FACTORS CORD SUNDERKOTTER,* MATTHIAS GOEBELER,* KLAUS SCHULZE-OsTHOFF,~ RANJIT BHARDWAJ* a n d CLEMENS SORG* *Institute of Experimental Dermatology, University of Miinster, Von-Esmarch-Strasse 56, D-W-4400 Miinster, Germany t lnstitute of Molecular Biology, Rijksuniversiteit Gent, Belgium Abstract--A majority of angiogenic factors has been shown to be produced by macrophages. This review will give a concise description of their biochemical nature, their isolation from macrophages and their angiogenic activity. Among the factors with mitogenic effects on endothelial cells are basic fibroblast growth factor (bFGF), transforming growth factor-alpha (TGF
